Suchergebnisse

Chapter 1: Why Happiness Studies? -- Chapter 2: Happiness as Wholebeing -- Chapter 3: The SPIRE of Happiness -- Chapter 4:The Twelve Principles of Happiness -- Chapter 5: Enter the Matrix -- Chapter 6: In the Workplace -- Chapter 7: In Schools -- Chapter 8: In Society -- Chapter 9: Toward a Happiness Revolution.

The difference between flourishing and floundering is 10X. The difference between quantity and quality is a factor of 10. The difference in levels of engagement is exponential. People functioning at the highest level are what the authors call 10x leaders. Research on these leaders consistently brought up five major strengths. This book teaches readers to become a 10x leader using these five key areas, the SHARP framework. ' Strengths: 10X leaders stop trying to eliminate weaknesses and learn to focus on their strengths ' Health: 10X leaders stop trying to eliminate stress and learn how to integrate periods of restoration ' Absorption: 10X leaders stop waiting for the lightning of focus and creativity to strike and learn how to achieve consistent engagement and presence ' Relationships: 10X leaders stop trying to exert power and control and learn to cultivate healthy relationships through positivity and authenticity ' Purpose: 10X leaders stop grinding out tasks and learn how to find meaning and commitment in everything they do The 10X elixir of peak performance comes not from focusing on just one of these areas, but from learning to light the fire of all five aspects of SHARP and functioning naturally with them on a daily basis. If you just cultivate one or two aspects of leadership skills you are unlikely to succeed. If one of the five isn't taken care of it affects the performance of the whole. But if you focus on all five areas, you will not only be more likely to find what helps you most, you have the best chance of enjoying the synergy of performance multiplication.

Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract. ; D.G. is supported by the Clore Israel Foundation. TMB is supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, Obra Social "La Caixa" and Secretaria d'Universitats i Recerca and CERCA Program del Departament d'Economia i Coneixement de la Generalitat de Catalunya. D.R. is an Investigator of the Howard Hughes Medical Institute and is also supported by an Allen Discovery Center for the Study of Human Brain Evolution funded the Paul G. Allen Family Foundation. C.L.-F. is supported by FEDER and BFU2015-64699-P grant from the Spanish government. R.P. was supported by ERC starting grant ADNABIOARC (263441). R.M.G. and J.M.O. are supported by NYSTEM contract C030133. Funding for the collection and processing of the 850K chimpanzee data was provided by the Leakey Foundation Research Grant for Doctoral Students, Wenner-Gren Foundation Dissertation Fieldwork Grant (Gr. 9310), James F. Nacey Fellowship from the Nacey Maggioncalda Foundation, International Primatological Society Research Grant, Sigma Xi Grant-in-Aid of Research, Center for Evolution and Medicine Venture Fund (ASU), Graduate Research and Support Program Grant (GPSA, ASU), and Graduate Student Research Grant (SHESC, ASU) to G.H. Collection of the chimpanzee bone from Tanzania was funded by the Jane Goodall Institute, and grants from the US National Institutes of Health (AI 058715) and National Science Foundation (IOS-1052693), and facilitated by Elizabeth Lonsdorf and Beatrice Hahn. ; Peer reviewed