Suchergebnisse

The ongoing global pandemic of COVID-19 poses unprecedented public health risks for governments and societies around the world, which have been exacerbated by the emergence of SARS-CoV-2 variants. Pharmaceutical interventions with high antiviral efficacy are expected to delay and contain the COVID-19 pandemic. Molnupiravir, as an oral antiviral prodrug, is active against SARS-CoV-2 and is now (23 February 2022) one of the seven widely-used coronavirus treatments. To estimate its antiviral efficacy of Molnupiravir, we built a granular mathematical within-host model. We find that the antiviral efficacy of Molnupiravir to stop the growth of the virus is 0.56 (95% CI: 0.49, 0.64), which could inhibit 56% of the replication of infected cells per day. There has been good progress in developing high-efficacy antiviral drugs that rapidly reduce viral load and may also reduce the infectiousness of treated cases if administered as early as possible.

Abstract
The origin of "deixis" is deiktikos (deictic) in Greek, meaning "pointing or showing". Since the Greek period, the phenomenon of deixis has been of considerable interest to philosophers and in the past hundred years or so it has also become an important subject of linguistic study, especially in pragmatics. In the study of deixis the choice between proximal and distal deixis has been a major focus, and philosophers and linguists have been trying hard to identify the various factors that determine the choice between the two demonstratives this and that. However, none of these attempts has done justice to the complexity and variety of the deictic expression that occurs in natural languages. The present paper tries to ascertain the various factors that affect the choice between the proximal and distal deixis this and that in spoken English. This study reveals that, in addition to relative distance, other factors such as the referential functions of the deixis (especially the speaker's assumption of the information status of the referents), the syntactic functions of the deixis (especially as head or modifier) and the speaker's attitudinal orientation also play an important role in the choice between this and that.

For many years, Beijing has suffered from severe air pollution. At present, fine particulate matter (PM2.5) pollution in the winter and ozone (O3) pollution in the summer constitute serious environmental problems. In this study, the combination of a comprehensive air quality model with particulate matter source apportionment technology (CAMx-PAST) and monitoring data was used for the high-spatial resolution source apportionment of secondary inorganic components (SNA: SO42−, NO3−, and NH4+) in PM2.5; their corresponding precursor gases (SO2, NO2, and NH3); and O3 in the winter and summer over Beijing. Emissions from residents, industry, traffic, agriculture, and power accounted for 54%, 25%, 14%, 5%, and 2% of PM2.5 in the winter, respectively. In the summer, the emissions from industry, traffic, residents, agriculture, and power accounted for 42%, 24%, 20%, 10%, and 4% of PM2.5, respectively. The monthly transport ratio of PM2.5 was 27% and 46% in the winter and summer, respectively. The regional transport of residential and industrial emissions accounted for the highest proportion of PM2.5. The regional transport of emissions had a significant effect on the SO42− and NO3− concentrations, whereas SO2 and NO2 pollution were mainly affected by local emissions, and NH4+ and NH3 were mainly attributed to agricultural emissions. Industrial and traffic sources were two major emission sectors that contributed to O3 pollution in Beijing. The monthly transport ratios of O3 were 31% and 65% in the winter and summer, respectively. The high-spatial resolution regional source apportionment results showed that emissions from Langfang, Baoding, and Tangshan had the greatest impact on Beijing's air pollution. This work's methods and results will provide scientific guidance to support the government in its decision-making processes to manage the PM2.5 and O3 pollution issues.

PurposeThe purpose of this paper is to examine the influence of high-performance work systems (HPWS) on unit performance relative to the mediating roles of collective human capital (CHC) at the unit level and perceived HPWS at the employee level.Design/methodology/approachData were collected from 181 branch managers and 504 employees. The proposed path model was tested using the statistical package M-plus (v. 7) using a 2-1-2 multilevel approach for mediation analysis.FindingsGenerally, branch managers actively implement HPWS, and employees perceive a fairly high level of HPWS. Further, the path model indicated that CHC at the unit level and perceived HPWS at the employee level partially mediate the relationship between implemented HPWS and unit performance.Originality/valueThis study is the first to explore multilevel mediating mechanisms in the context of the largest four state-owned banks in China. A 2-1-2 multilevel analysis procedure was used to separate measurement error into relevant employee- and branch-level components to create more precise assessments of multivariate associations. Such analyses have not yet been conducted in research on HPWS prior to this study of the Chinese banking sector, but they are essential for teasing out the micro- and macro-level effects of HPWS.

With rapid urbanization and the requirements for new buildings and infrastructure, cement production is expected to increase in China. Meanwhile, China's energy consumption and carbon emissions associated with cement industry are expected to increase, as cement production is one of the most energy intensive industries. Introducing new and more pertinent technologies with better management, as indicated by government goals and measures, can improve energy efficiency and reduce carbon emission. However, many challenges and uncertainties in the cement industry have been addressed without considering several interconnected processes among sectors including industry, energy, construction, and services, which lead to little improvements in the industry. Nexus approaches are recognized as effective methods to simultaneously examine interactions among multiple sectors with various elements. This research intends to provide insights for future energy-cement-carbon emission nexus, through integrated assessment capabilities, related to China's new urbanization planning toward 2050. Several challenges and uncertainties, including different trends in population growth, structural transformation of economic driving forces, and new but stricter policy targets for resource use efficiency and environment production, are put into multiple scenarios. The results of our analysis provide perspectives on future direction to underscore the growing interconnection among energy, cement and carbon emission with clear and more specific roadmap for promoting integrated planning, management and governance.

AbstractDetecting infectious aerosols is central for gauging and countering airborne threats. In this regard, the Coriolis® µ cyclonic air sampler is a practical, commercial collector that can be used with various analysis methods to monitor pathogens in air. However, information on how to operate this unit under optimal sampling and biosafety conditions is limited. We investigated Coriolis performance in aerosol dispersal experiments with polystyrene microspheres and Bacillus globigii spores. We report inconsistent sample recovery from the collector cone due to loss of material when sampling continuously for more than 30 min. Introducing a new collector cone every 10 min improved this shortcoming. Moreover, we found that several surfaces on the device become contaminated during sampling. Adapting a high efficiency particulate air-filter system to the Coriolis prevented contamination without altering collection efficiency or tactical deployment. A Coriolis modified with these operative and technical improvements was used to collect aerosols carrying microspheres released inside a Biosafety Level-3 laboratory during simulations of microbiological spills and aerosol dispersals. In summary, we provide operative and technical solutions to the Coriolis that optimize microbiological air sampling and improve biosafety.