Suchergebnisse

AbstractGanoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor properties. This study aimed to illustrate the efficacy of GL extracts (GLE) on treating endometrial cancer (EC) and explore the underlying mechanisms via network pharmacology and experimental validation. Network pharmacological analysis was conducted to explore the therapeutic efficacy and mechanisms of GL on EC. In vitro experimental validation was performed on human endometrial cancer cell lines HEC-1-A and KLE. Network pharmacology revealed that key targets of GL against EC were primarily associated with the Rap1 signaling pathway. In in vitro experiments, GLE or GGTI-298 (a GTPase inhibitor) treatment inhibited cell proliferation and migration, promoted cell apoptosis, increased caspase-3 level, and arrested cell cycle in G1 phase in HEC-1-A and KLE cells. GLE increased the protein expression of Rap1-GTP, p-AKT, and p-ERK2 in HEC-1-A and KLE cells. Moreover, GGTI-298 enhanced the effects of GLE on suppressing the malignant progression of EC cells and on activating Rap1 signaling pathway. GLE inhibited the malignant progression of EC cells probably via activating the Rap1 signaling pathway.

This thesis talks about Chinese harmonious culture in three aspects. The first aspect is the contents, characteristics and functions of Chinese harmonious culture. The second aspect is to discuss two basic theory recourse of Chinese harmonious culture, one is its traditional culture theory, and another is the western culture theory. The third aspect is to analyze the method which China government should pay more attention to their progress of promote culture development.

Purpose
– The purpose of this paper is to review a sample of the literature relating to the financial impacts of supply chain management (SCM) and suggest future research directions.


Design/methodology/approach
– 49 research articles between 1990 and 2011 are collected from various academic databases and online sources. By conducting content analysis, empirical findings on the relationship between SCM and firm-level financial performance are summarized and classified. Performance drivers are identified from the literature to guide future SC practices.


Findings
– Both accounting- and market-based financial performances are closely related to the effectiveness of SCM. As important performance drivers, sourcing strategy, information technology (IT), SC integration, and external relationships play critical roles to improve firm-level financial performance. In particular, optimal levels of outsourceability, SC alignment and integration with IT infrastructure, and SC relationship management are essential to realize full financial advantages of effective SCM.


Practical implications
– A better understanding and demonstration on how SCM makes positive contributions to financial performance help SCM managers to better communicate with top management and substantiate their roles in the organization.


Originality/value
– To the authors' best knowledge, this paper is the first and the most comprehensive literature review in a much-needed research area. A number of performance drivers are identified to provide practical guidance. Some promising research areas are suggested for further investigation.

AbstractObjectiveThe goal was to examine (a) how parental involvement affects mental health in left‐behind children (LBC), and (b) how the interaction effect of parental involvement and grandparent involvement affects mental health in LBC.BackgroundGiven the rapid industrialization and urbanization in China, a substantial number of rural laborers have migrated to cities to earn a living. However, it is difficult for many children to stay with their parents and they have to be left behind.MethodsThe sample consisted of 309 left‐behind children who had grandparents to care for them. The participants completed the Inventory of Father Involvement, Inventory of Mother Involvement, Inventory of Closest Grandparent Involvement, Needs Satisfaction Questionnaire, and Emotional Experience of Well‐being Questionnaire.ResultsNeeds satisfaction mediated the effect of father involvement on emotional well‐being (EWB) and the effect of mother involvement on EWB in LBC. The closest grandparent involvement of LBC moderated the effect of mother involvement on needs satisfaction, but it did not moderate the effect of father involvement on needs satisfaction. The closest grandparent involvement of LBC moderated the indirect effect of mother involvement on EWB through needs satisfaction.ConclusionsNeeds satisfaction is an essential mediator between parental involvement and EWB. Grandparental involvement of LBC plays a complementary role in mother involvement. Their interaction effect facilitates the fulfilment of needs, and improves their EWB in LBC.ImplicationsThe mental health of LBC can be improved by helping their mothers and grandparents to meet various needs of LBC.

The move to introduce technology enhanced learning (TEL) is a trend that has been observed for decades. Following the disruption arising from Covid-19 pandemic, there has been a move to remote teaching in universities across the world. This move has put the transformation or digital revolution in the limelight in the media. TEL is of strategic importance to the conduct of teaching, learning and research in education internationally. TEL, when combined with the growing benefits of open approaches to education, leads to a potentially transformational means of learning. In this paper the authors introduce some examples of research projects from the Open University's OpenTEL research grouping. These examples highlight some of the work conducted relating to supporting students, universities, and communities using TEL during the pandemic. OpenTEL research has identified that Covid-19 has exposed the need for better institutional support for students who are facing stress and disruption in their studies; collaboration among higher educational institutions to share knowledge; better engagement in the online pivot ; and understanding of the possibilities (and limitations) for online tools to maintain existing research communities.

Rubber farming, land rental market, land use choice, intercropping, ecosystem protection. - Kautschuk, Landmietmarkt, Landnutzung, Zwischenfruchtbau, Ökosystem-Schutz