Suchergebnisse
Filter
132 Ergebnisse
Sortierung:
Editorial: The first ten years of activity of EFSA: A success story
In: EFSA journal, Band 10, Heft 10
ISSN: 1831-4732
Main achievements and challenges of the EFSA Scientific Committee since its inception
In: EFSA journal, Band 10, Heft 10
ISSN: 1831-4732
Environmental condition of the Mediterranean Sea: European Community countries
In: Environment & assessment 5
Accidental release of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Sèveso, Italy
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 4, Heft 3, S. 327-338
ISSN: 1090-2414
EFSA's approach to identifying emerging risks in food and feed: taking stock and looking forward
In: EFSA journal, Band 10, Heft 10
ISSN: 1831-4732
Statement on the derivation of Health‐Based Guidance Values (HBGVs) for regulated products that are also nutrients
In: EFSA journal, Band 19, Heft 3
ISSN: 1831-4732
Evaluation of existing guidelines for their adequacy for the microbial characterisation and environmental risk assessment of microorganisms obtained through synthetic biology
In: EFSA journal, Band 18, Heft 10
ISSN: 1831-4732
Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health
In: EFSA journal, Band 16, Heft 7
ISSN: 1831-4732
Scientific motivations and criteria to consider updating EFSA scientific assessments
In: EFSA journal, Band 15, Heft 3
ISSN: 1831-4732
Safety evaluation of the food enzyme triacylglycerol lipase from the non‐genetically modified Mucor circinelloides strain AE‐LMH
In: EFSA journal, Band 21, Heft 1
ISSN: 1831-4732
Safety evaluation of the food enzyme containing trypsin, chymotrypsin, α‐amylase and triacylglycerol lipase from porcine pancreas
In: EFSA journal, Band 20, Heft 4
ISSN: 1831-4732
A systems‐based approach to the environmental risk assessment of multiple stressors in honey bees
In: EFSA journal, Band 19, Heft 5
ISSN: 1831-4732
Safety evaluation of the food enzyme maltogenic α‐amylase from the genetically modified Saccharomyces cerevisiae strain LALL‐MA
In: EFSA journal, Band 19, Heft 2
ISSN: 1831-4732
Guidance Document on Scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals
This guidance document provides harmonised and flexible methodologies to apply scientific criteria and prioritisation methods for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals. In the context of EFSA's risk assessments, the problem formulation step defines the chemicals to be assessed in the terms of reference usually through regulatory criteria often set by risk managers based on legislative requirements. Scientific criteria such as hazard‐driven criteria can be used to group these chemicals into assessment groups. In this guidance document, a framework is proposed to apply hazard‐driven criteria for grouping of chemicals into assessment groups using mechanistic information on toxicity as the gold standard where available (i.e. common mode of action or adverse outcome pathway) through a structured weight of evidence approach. However, when such mechanistic data are not available, grouping may be performed using a common adverse outcome. Toxicokinetic data can also be useful for grouping, particularly when metabolism information is available for a class of compounds and common toxicologically relevant metabolites are shared. In addition, prioritisation methods provide means to identify low‐priority chemicals and reduce the number of chemicals in an assessment group. Prioritisation methods include combined risk‐based approaches, risk‐based approaches for single chemicals and exposure‐driven approaches. Case studies have been provided to illustrate the practical application of hazard‐driven criteria and the use of prioritisation methods for grouping of chemicals in assessment groups. Recommendations for future work are discussed.
BASE