Suchergebnisse

El artículo profundiza en el concepto de parlamentos sensibles al género y aplica nuevas categorías analíticas en el caso del Parlamento Vasco. Los principales objetivos son analizar la presencia y rol de las mujeres parlamentarias, conocer la agenda de género, estudiar las medidas de igualdad puestas en práctica en la organización y valorar el grado en que el Parlamento Vasco puede considerarse sensible al género. El estudio aborda la representación política (tanto descriptiva como sustantiva), el desarrollo de las funciones legislativas, de control y de impulso y la dimensión organizativa interna a lo largo de las legislaturas del siglo xxi. La investigación operacionaliza el nivel de sensibilidad al género de los parlamentos y concluye aplicando dicho concepto al Parlamento Vasco mediante la creación de un índice de medición.

Meet the discredit of the judicial current order problem we think about the convenience of knowing which the common features are, it means, the three pillars that should guide any jurisdictional fair system, like the defense right, effective protection of the court and the procedural time. Then we stop in the consequences of that problem and like it can be corrected inside the European Union with the objective of reaching «An Europe of the Law and the Justice », just as it the PROGRAM DE STOCKHOLM establishes. By that, the effective protection of the court constitutes the fundamental base of the State of Right, supported constitutionally (justice, artificial security, legality, etc.) and it articulates the individual underlying guarantees in the jurisdictional processes. This way, because the access to the Justice, endorsed by the effective protection of the court to personal title and a Jurisdictional Control on the Public Administrations are manifestations of the scale of values that sustains the modern social and democratic state of right and they are perceived by the civil society as constituent factors of the political legitimation; when this manifestations are depreciated socially, a distancing takes place between the Institutions and physical people that anything good they denounce, according to the European historical experience. ; Frente al problema del desprestigio del orden judicial actual nos planteamos la conveniencia de conocer cuáles son los rasgos comunes, los tres pilares que deben orientar cualquier sistema jurisdiccional justo, como son el Derecho de Defensa, la Tutela Judicial Efectiva y el Tiempo Judicial. Después nos detenemos en las consecuencias de ese problema y como puede corregirse a nivel de la Unión Europea de acuerdo con el objetivo de alcanzar «Una Europa de la Ley y de la Justicia», tal como lo establece el PROGRAMA DE ESTOCOLMO. En consecuencia, el Derecho a la Tutela Judicial constituye la base fundamental del Estado de Derecho, soportado constitucionalmente (justicia, seguridad jurídica, legalidad, etc.) y articula las garantías individuales subyacentes en los procesos jurisdiccionales. Así, pues, el acceso a la Justicia, avalado por la existencia de una Tutela Judicial Efectiva a título personal y de un Control Jurisdiccional sobre las Administraciones Públicas son manifestaciones de la escala de valores que sustenta al moderno Estado Social y Democrático de Derecho y son percibidas por la Sociedad Civil como factores constitutivos de su legitimación política, de tal forma que cuando dichas manifestaciones se deprecian socialmente, se produce un distanciamiento entre las Instituciones y las personas físicas, que nada bueno presagian, según la histórica experiencia europea.Meet the discredit of the judicial current order problem we think about the convenience of knowing which the common features are, it means, the three pillars that should guide any jurisdictional fair system, like the defense right, effective protection of the court and the procedural time. Then we stop in the consequences of that problem and like it can be corrected inside the European Union with the objective of reaching «An Europe of the Law and the Justice », just as it the PROGRAM DE STOCKHOLM establishes. By that, the effective protection of the court constitutes the fundamental base of the State of Right, supported constitutionally (justice, artificial security, legality, etc.) and it articulates the individual underlying guarantees in the jurisdictional processes. This way, because the access to the Justice, endorsed by the effective protection of the court to personal title and a Jurisdictional Control on the Public Administrations are manifestations of the scale of values that sustains the modern social and democratic state of right and they are perceived by the civil society as constituent factors of the political legitimation; when this manifestations are depreciated socially, a distancing takes place between the Institutions and physical people that anything good they denounce, according to the European historical experience.

This is the peer reviewed version of the following article: E. Añón, A. M. Costero, P. Amorós, J. El Haskouri, R. Martínez-Mánez, M. Parra, S. Gil, P. Gaviña, M. C. Terencio, M. Alfonso, ChemistrySelect 2020, 5, 3618., which has been published in final form at https://doi.org/10.1002/slct.202000417. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. ; [EN] Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. Here we present the synthesis and characterization of mesoporous gated nanoparticles (two sets) for the controlled release of alendronate. The first set of nanoparticles (S1) were loaded with sulforhodamine B and capped with a peptide that could be selectively hydrolyzed by cathepsin K enzyme (overexpressed in osteoclasts). The second set (S2) was functionalized with aminopropyl moieties, loaded with nitrobenzofurazan labelled alendronate and capped with the same peptide. Both nanoparticles were internalized by RAW 264.7 macrophages (which could differentiate in osteoclasts) and were able to release its entrapped cargo in the presence of cathepsin K added in the macrophage lysates. Using S2 nanoparticles 4.2% of the total alendronate amount in contact with the cells is liberated inside them and could produce its therapeutic effect. ; We thank the Spanish Government (RTI2018-100910-B-C41, RTI2018-100910-B-C42 (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (PROMETEU/2018/024) for support. SCSIE (Universitat de Valencia) is gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS "NANBIOSIS" at the Universitat of Valencia. ; Añón, E.; Costero, AM.; Amorós Del Toro, P.; El Haskouri, J.; Martínez-Máñez, R.; Parra Álvarez, M.; Gil ...