Suchergebnisse

Recent work in political science asserts a growth in prominence of civil society in international public policy processes, something that has been to this point under-addressed in the field of public policy research in communication. This article undertakes an analysis of the role of civil society in the recent EU policy debate on re-allocation of spectrum, one of the most strategically significant communication resources. The article explains the presence of the voice of civil society through construction of a model of international civil society strategic alignment and application of it to the spectrum case. The case provides evidence of how, in an environment generally dominated by state and commercial interests, civil society actors have been able to articulate influentially – though ultimately in a limited way - their public policy preferences.

This experiment investigated the influence of warnings, signal words, and a signal icon on perceived hazard of consumer products. Under the guise of a marketing research study, 135 people (high school students, college students, and participants from a shopping mall) rated product labels on six dimensions, including how hazardous they perceived the products to be. A total of 16 labels from actual household products were used: 9 carried the experimental conditions, and 7 were filler product labels that never carried a warning. Five conditions presented the signal words NOTE, CAUTION, WARNING, DANGER, and LETHAL together with a brief warning message. In another two conditions, a signal icon (exclamation point surrounded by a triangle) was presented together with the terms DANGER and LETHAL. In the final two conditions, one lacked a signal word but retained the warning message, and the other lacked both the warning message and the signal word. Results showed that the presence of a signal word increased perceived product hazard compared with its absence. Significant differences were noted between extreme terms (e.g., NOTE and DANGER) but not between terms usually recommended in warning design guidelines (e.g., CAUTION and WARNING). The signal icon showed no significant effect on hazard perception. Implications of the results and the value of the methodology for future warnings investigations are discussed.

In order to address the oft-cited societal, economic, and health and social care impacts of neurodegenerative diseases, such as Alzheimer's disease, we must move decisively from reactive to proactive clinical practice and to embed evidence-based brain health education throughout society. Most disease processes can be at least partially prevented, slowed, or reversed. We have long neglected to intervene in neurodegenerative disease processes, largely due to a misconception that their predominant symptom — cognitive decline — is a normal, age-related process, but also due to a lack of multi-disciplinary collaboration. We now understand that there are modifiable risk factors for neurodegenerative diseases, that successful management of common comorbidities (such as diabetes and hypertension) can reduce the incidence of neurodegenerative disease, and that disease processes begin (and, crucially, can be detected, reduced, and delayed, prevented, or treated) decades earlier in life than had previously been appreciated. Brain Health Scotland, established by Scottish Government and working in partnership with Alzheimer Scotland, propose far-reaching public health and clinical practice approaches to reduce neurodegenerative disease incidence. Focusing here on Brain Health Scotland's clinical offerings, we present the Scottish Model for Brain Health Services. To our knowledge, the Scottish Model for Brain Health, built on foundations of personalised risk profiling, targeted risk reduction and prevention, early disease detection, equity of access, and harnessing comprehensive data to assist in clinical decision-making, marks the first example of a nationwide approach to overhauling clinical, societal, and political approaches to the prevention, assessment, and treatment of neurodegenerative disease.

Primary familial brain calcification (PFBC) is a neurological disease characterized by calcium phosphate deposits in the basal ganglia and other brain regions and has thus far been associated with SLC20A2, PDGFB or PDGFRB mutations. We identified in multiple families with PFBC mutations in XPR1, a gene encoding a retroviral receptor with phosphate export function. These mutations alter phosphate export, implicating XPR1 and phosphate homeostasis in PFBC. ; Lung GO Sequencing Project ; Lung GO Sequencing Project ; Women's Health Initiative (WHI) Sequencing Project ; Broad GO Sequencing Project ; Seattle GO Sequencing Project ; Heart GO Sequencing Project ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Institute of Neurological Disorders & Stroke (NINDS) ; Association Francaise contre les Myopathies ; Ligue Nationale contre le Cancer (Comite de l'Herault) ; Fondation pour la Recherche Medicale ; FEDER European Union Languedoc-Roussillon grant ; National Institute of Neurological Disorders and Stroke ; Informatics Center for Neurogenetics and Neurogenomics ; Fondation pour la Recherche Medicale ; Institut National du Cancer (INCA) France ; Labex GR-Ex ; Labex EpiGenMed ; French National Research Agency (ANR) ; Institut National de la Sante et de la Recherche Medicale (Inserm) ; European Commission ; Instituto de Salud Carlos III (ISCIII) ; INNOPHARMA project MINECO-USC ; Servizo Galego de Saúde (SERGAS) ; National Council for Scientific and Technological Development (CNPq) ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Institute of Mental Health (NIMH) ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Institute of Neurological Disorders & Stroke (NINDS) ; University Hospital of Rouen ; French CNR-MAJ ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Heart Lung & Blood Institute (NHLBI) ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Institute of Mental Health (NIMH) ; United States Department of Health & Human Services ; National Institutes of Health (NIH) - USA ; NIH National Institute of Neurological Disorders & Stroke (NINDS)