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AbstractIntroductionYouTube's popularity as a health information source raises concerns about credibility due to the absence of peer review. Therefore, this study assessed the content quality and reliability of YouTube videos related to oral appliance therapy for obstructive sleep apnea (OSA).MethodsVideos were systematically searched on August 20, 2023, using terms determined through Google Trends. Videos were included based on predefined criteria and independently assessed by two researchers. Video demographics were extracted. Video quality was evaluated using audio‐visual (AV) quality, video information and quality index (VIQI), global quality score (GQS), and reliability using a modified DISCERN tool (mDISCERN). High and low‐content videos were defined based on the customized 10‐point scoring system. Inter‐ and intra‐examiner reliability of scoring system were calculated.ResultsMost videos were educational (46.3%), presented by dental sleep medicine specialists (42.6%), and aimed at laypersons (63%), with the majority originating from the United States (79.6%). The final 54 videos were categorized as high‐content (n = 29, 54%) and low‐content (n = 25, 46%). High‐content videos had more views, comments, and longer video durations (7.07 ± 6.04 min). Significant differences (p < .05) were observed among high and low‐content videos in total VIQI, mDISCERN, GQS, and TCS. Moderate correlations were found between GQS and TCS (r = 0.721), mDISCERN and VIQI (r = 0.649), GQS and VIQI (r = 0.601), and AV quality and VIQI (r = 0.531).ConclusionThe study highlights variable content quality and reliability of YouTube videos on oral appliance therapy for OSA, emphasizing the need for guidelines to enhance their educational value and deliver reliable, evidence‐based information to patients.