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Open Access#22009
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
Gudmundsson, Julius; Sulem, Patrick; Gudbjartsson, Daniel F; Blondal, Thorarinn; Gylfason, Arnaldur; Agnarsson, Bjarni A; Benediktsdottir, Kristrun R; Magnusdottir, Droplaug N
Gudmundsson, Julius; Sulem, Patrick; Gudbjartsson, Daniel F; Blondal, Thorarinn; Gylfason, Arnaldur; Agnarsson, Bjarni A; Benediktsdottir, Kristrun R; Magnusdottir, Droplaug N; Orlygsdottir, Gudbjorg; Jakobsdottir, Margret; Stacey, Simon N; Sigurdsson, Asgeir; Wahlfors, Tiina; Tammela, Teuvo; Breyer, Joan P; McReynolds, Kate M; Bradley, Kevin M; Saez, Berta; Godino, Javier; Navarrete, Sebastian; Fuertes, Fernando; Murillo, Laura; Polo, Eduardo; Aben, Katja K; van Oort, Inge M; Suarez, Brian K; Helfand, Brian T; Kan, Donghui; Zanon, Carlo; Frigge, Michael L; Kristjansson, Kristleifur; Gulcher, Jeffrey R; Einarsson, Gudmundur V; Jonsson, Eirikur; Catalona, William J; Mayordomo, Jose I; Kiemeney, Lambertus A; Smith, Jeffrey R; Schleutker, Johanna; Barkardottir, Rosa B; Kong, Augustine; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Stefansson, Kari
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field ; We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population. ; info:eu-repo/grantAgreement/EC/FP7/218071 European Union 202059 V Foundation US Department of Veterans Affairs Academy of Finland Sigrid Juselius Foundation Pirkanmaa Hospital District, Tampere University Hospital
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