Biochemical effects of the pharmaceutical drug paracetamol on Anguilla anguilla
In: Environmental science and pollution research: ESPR, Band 22, Heft 15, S. 11574-11584
ISSN: 1614-7499
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In: Environmental science and pollution research: ESPR, Band 22, Heft 15, S. 11574-11584
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 28, Heft 37, S. 51440-51452
ISSN: 1614-7499
11 pages, 1 figure, 2 tables ; Pharmaceuticals such as non-steroidal anti-inflammatory drugs (NSAIDs) have been found in the marine environment. Although there is a large body of evidence that pharmaceutical drugs exert negative impacts on aquatic organisms, especially in the freshwater compartment, only limited studies are available on bioconcentration and the effects of NSAIDs on marine organisms. Bivalves have a high ecological and socio-economic value and are considered good bioindicator species in ecotoxicology and risk assessment programs. Therefore, this review summarizes current knowledge on the bioconcentration and the effects of three widely used NSAIDs, diclofenac, ibuprofen and paracetamol, in marine bivalves exposed under laboratory conditions. These pharmaceutical drugs were chosen based on their environmental occurrence both in frequency and concentration that may warrant their inclusion in the European Union Watch List. It has been highlighted that ambient concentrations may result in negative effects on wild bivalves after long-term exposures. Also, higher trophic level organisms may be more impacted due to food-chain transfer (e.g., humans are shellfish consumers). Overall, the three selected NSAIDs were reported to bioconcentrate in marine bivalves, with recognized effects at different life-stages. Immune responses were the main target of a long-term exposure to the drugs. The studies selected support the inclusion of diclofenac on the European Union Watch List and highlight the importance of extending research for ibuprofen and paracetamol due to their demonstrated negative effects on marine bivalves exposed to environmental realistic concentrations, under laboratory conditions ; Ângela Almeida benefited from PhD grant (SFRH/BD/110218/2015) given by the National Funds through the Portuguese Science Foundation (FCT), supported by FSE and Programa Operacional Capital Humano (POCH) e European Union. Rosa Freitas was funded by national funds (OE), through FCT – Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. This work was also financially supported by the project BISPECIAl: BIvalveS under Polluted Environment and ClImate chAnge PTDC/CTA-AMB/28425/2017 (POCI-01-0145-FEDER-028425) funded by FEDER, through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI), and by national funds (OE), through FCT/MCTES. Thanks are due for the financial support to CESAM (UIDB/50017/2020+UIDP/50017/2020), to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. The authors also acknowledge to the RED RIESCOS - Evaluación de los Efectos de los Contaminantes Emergentes en Organismos Acuáticos y sobre la Salud Humana, from the Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED) with the reference 419RT0578
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In: Environmental science and pollution research: ESPR, Band 18, Heft 4, S. 655-662
ISSN: 1614-7499
Portuguese commercial Elasmobranch landings were analysed for the period 1986 – 2009 and revealed that some species may be in danger of overfishing. Landings totalled 122,515 mt, with an average of 5,105 mt landed yearly, with captured sharks, skates and rays representing 8 orders, 14 families and 44 species. Annual landings for the fishery generally decreased over time, with a corresponding increase in price per kilogram. The most landed group, skates (Raja sp.), accounted for 33% of the landings, or 40,344 mt. They were followed by lesser spotted catsharks (Scyliorhinus sp.), Portuguese dogfish (Centroscymnus coelolepis), leafscale gulper sharks (Centrophorus squamosus), blue sharks (Prionace glauca) and gulper sharks (Centrophorus granulosus) (accounting for 12%, 11%, 10%, 9% and 8% of the landings, respectively). In the absence of CPUE data, comparative trends of landings and price over time were used as an indicator of the status of specific Elasmobranch species. Centrophorus granulosus, smoothounds (Mustelus sp.), torpedo rays (Torpedo sp.), requiem sharks (Carcharhinus sp.) and angel sharks (Squatina sp.) displayed indications of possible over-exploitation, with significantly decreasing landings and increasing prices over time, and merit the focus of future research. The pattern shown by fishing effort over time (i.e. number of fishing vessels over time) displayed a marked decrease, although this was substantially less than the decrease shown by landings of the species mentioned earlier. It is therefore unlikely that such a decrease in landings is justified solely by a decrease in number of fishing vessels. Similarly, the increase in price shown for all species was largely superior to the increase in inflation, which would suggest that the increase in inflation alone would not account for the increase in price. All results and data corroborate the notion that some species are, in fact, over-exploited and in need of immediate management and conservation measurements. These findings were substantiated by min/max auto-correlation factor analysis (MAFA), which shows that the most important trend is that of a decrease in landings of those species where overfishing in indicated. ; Oma – Observatório do Mar dos Açores ; MARE – Centro de Ciências do Mar e do Ambiente ; IMAR – Instituto do Mar ; DOP – Departamento de Oceanografia e Pescas ; Universidade dos Açores ; info:eu-repo/semantics/publishedVersion
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In: Environmental science and pollution research: ESPR, Band 16, Heft 6, S. 679-688
ISSN: 1614-7499
As a result of a widespread application in numerous industrial processes, chromium is a contaminant of many environmental systems. Chromium and their compounds are toxic to both invertebrates and vertebrates and, for this reason, there has been a search for suitable and less toxic alternatives. Molybdenum compounds have been studied as alternative to chromium compounds for some industrial applications. The toxicity of chromium is well known but the effects of molybdenum and molybdenum mining on natural populations and communities of freshwater invertebrates have not often been studied. However, chromium, and molybdenum (and their compounds) are included in the same list (List II) of European Union dangerous substances. In this study, the acute and chronic effects of sodium molybdate and sodium dichromate to Daphnia magna Straus were evaluated. Furthermore, in vitro and in vivo effects of these two metals on acetylcholinesterase (AChE) activity of D. magna Straus were investigated. LC50 values determined at 48 h were 0.29 and 2847.5 mg L-1 for chromium (as sodium dichromate) and molybdenum (as sodium molybdate), respectively. No significant in vitro effects of both metals on AChE were found. However, both toxicants inhibited AChE in vivo at concentrations under the respective 48-h LC50 values. Both sodium dichromate and sodium molybdate inhibited the reproduction and growth of D. magna, but the concentrations inducing significant effects were different for the two chemicals. Sodium molybdate had significant lower toxicity to D. magna Straus than sodium dichromate. ; http://www.sciencedirect.com/science/article/B6WDM-45F558P-34/1/d90649021ed4b14cef54a1cad8cba55c
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In: Environmental science and pollution research: ESPR, Band 30, Heft 54, S. 116120-116133
ISSN: 1614-7499
AbstractElectrical and electronic equipment reaching the end of its useful life is currently being disposed of at such an alarmingly high pace that raises environmental concerns. Together with other potentially dangerous compounds, electronic waste contains the rare-earth element gadolinium (Gd), which has already been reported in aquatic systems. Additionally, the vulnerability of aquatic species to this element may also be modified when climate change related factors, like increase in temperature, are taken into consideration. Thus, the present study aimed to evaluate the toxicity of Gd under a scenario of increased temperature in Mytilus galloprovincialis mussels. A multi-biomarker approach and Gd bioaccumulation were assessed in mussels exposed for 28 days to 0 and 10 μg/L of Gd at two temperatures (control – 17 °C; increased – 22 °C). Results confirmed that temperature had a strong influence on the bioaccumulation of Gd. Moreover, mussels exposed to Gd alone reduced their metabolism, possibly to prevent further accumulation, and despite catalase and glutathione S-transferases were activated, cellular damage seen as increased lipid peroxidation was not avoided. Under enhanced temperature, cellular damage in Gd-exposed mussels was even greater, as defense mechanisms were not activated, possibly due to heat stress. In fact, with increased temperature alone, organisms experienced a general metabolic depression, particularly evidenced in defense enzymes, similar to the results obtained under Gd-exposure. Overall, this study underlines the importance of conducting environmental risk assessment taking into consideration anticipated climate change scenarios and exposures to emerging contaminants at relevant environmental concentrations.
In: Environmental science and pollution research: ESPR, Band 23, Heft 1, S. 266-272
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 22, Heft 18, S. 14241-14247
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 20, Heft 7, S. 4671-4680
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 17, Heft 6, S. 1217-1229
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 26, Heft 11, S. 11326-11335
ISSN: 1614-7499
Acute organophosphorus (OP) intoxication is a worldwide clinical and public health problem. In addition to cholinergic crisis, neurodegeneration and brain damage are hallmarks of the severe form of this toxidrome. Recently, we generated a chemical model of severe acute OP intoxication in zebrafish that is characterized by altered head morphology and brain degeneration. The pathophysiological pathways resulting in brain toxicity in this model are similar to those described in humans. The aim of this study was to assess the predictive power of this zebrafish model by testing the effect of a panel of drugs that provide protection in mammalian models. The selected drugs included "standard therapy" drugs (atropine and pralidoxime), reversible acetylcholinesterase inhibitors (huperzine A, galantamine, physostigmine and pyridostigmine), N-methyl-d-aspartate (NMDA) receptor antagonists (MK-801 and memantine), dual-function NMDA receptor and acetylcholine receptor antagonists (caramiphen and benactyzine) and anti-inflammatory drugs (dexamethasone and ibuprofen). The effects of these drugs on zebrafish survival and the prevalence of abnormal head morphology in the larvae exposed to 4 µM chlorpyrifos oxon [1 × median lethal concentration (LC50)] were determined. Moreover, the neuroprotective effects of pralidoxime, memantine, caramiphen and dexamethasone at the gross morphological level were confirmed by histopathological and transcriptional analyses. Our results demonstrated that the zebrafish model for severe acute OP intoxication has a high predictive value and can be used to identify new compounds that provide neuroprotection against severe acute OP intoxication. © 2016, The Author(s). ; This work was supported in part by the US Army ERDC-IRO (W912HZ-13-BAA-01; D.R.), the NATO SfP project MD.SFPP 984777 (D.R.), the Portuguese Foundation for Science and Technology Grant SFRH/BPD/78342/2011 (Programme POPH—QREN through the Portuguese Ministry of Education and Science and the European Social Fund; M.F.) and the Spanish Government (CTM2014-51985-R; D.R., E.P, M.F.). We also are grateful to Dr. Martí Pumarola from the Departament de Medicina i Cirurgia Animals of the UAB for their valuable comments on neuropathology. ; Peer reviewed
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In: Environmental science and pollution research: ESPR, Band 23, Heft 13, S. 13276-13287
ISSN: 1614-7499