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Long-term groundwater geochemical evolution induced by coal mining activities—a case study of floor confined limestone aquifer in Yaoqiao Coal Mine, Jiangsu, China
In: Environmental science and pollution research: ESPR, Band 30, Heft 42, S. 96252-96271
ISSN: 1614-7499
Bacterial community compositions in sediment polluted by perfluoroalkyl acids (PFAAs) using Illumina high-throughput sequencing
In: Environmental science and pollution research: ESPR, Band 23, Heft 11, S. 10556-10565
ISSN: 1614-7499
Effects of ambient temperature on outpatient visits for dermatitis in Xinxiang, China: a time-series analysis
In: Environmental science and pollution research: ESPR, Band 29, Heft 11, S. 15999-16005
ISSN: 1614-7499
Dissolved organic matter composition and fluorescence characteristics of the river affected by coal mine drainage
In: Environmental science and pollution research: ESPR, Band 30, Heft 19, S. 55799-55815
ISSN: 1614-7499
AMPH-1 As A Critical Tumor Suppressor That Inhibits Osteosarcoma Progression
Haiyun Zhang,1,* Yujie Liu,2,* Kehan Xu,2,* Kai Mao,1 Weidong Han,1 Feifan Xu,1 Wei Wan,2 Yajun Sun3 1Department of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China; 2Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China; 3Department of Laboratory Medicine, The Fourth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China*These authors contributed equally to this workCorrespondence: Yajun Sun; Wei WanDepartment of Laboratory Medicine, The Fourth People's Hospital of Nantong, Chenggang Road, Jiangsu 226000, People's Republic of ChinaEmail yajun_sun1@163.com; wei_wan66@163.comIntroduction: Amphiphysin 1 (AMPH-1) is involved in endocytosis, and its expression is upregulated in osteosarcoma compared with osteofibrous dysplasia.Methods: We investigated the role of AMPH-1 in osteosarcoma cells via both gain-of-function and loss-of-function experiments.Results: Knockdown of AMPH-1 in osteosarcoma cells promoted cell cycle progression and cell proliferation and attenuated apoptosis. Notably, silencing AMPH-1 increased osteosarcoma progression in a mouse tumor model. The results obtained upon AMPH-1 knockdown and AMPH-1 overexpression indicates that AMPH-1 is involved in regulating MEK/ERK signaling.Conclusion: These data suggest that AMPH-1 plays an important role in osteosarcoma and may represent a novel therapeutic target for osteosarcoma treatment.Keywords: AMPH-1, osteosarcoma, ERK signaling pathway
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