The Biology of Senescence: A Translational Approach
In: Practical Issues in Geriatrics Ser.
Intro -- Acknowledgment -- Abbreviations -- Contents -- 1: Introduction -- References -- 2: The Emerging Medical Landscape -- 2.1 The Overwhelming Human Responsibility -- 2.2 The Two Recent Epidemiological Transitions -- 2.2.1 Throughout the World -- 2.3 The Emergencies -- 2.3.1 The Two Out-Of-Control Risks: Nuclear Power and Poverty -- 2.3.2 Age, the First of the Emerging Risks -- 2.3.3 Incidence of Non-Transmissible Chronic Diseases -- 2.3.4 Other Age-Linked Diseases -- References -- 3: The Origins of Ageing -- 3.1 Genome Instability -- 3.2 Genetics and Heredity -- 3.3 Telomeres and Telomerase -- 3.4 Proteostasis -- 3.5 Epigenetics -- 3.6 Microbiota -- References -- 4: The Senescent Cell, SC -- 4.1 The Overview -- 4.2 Consequences of Stem/Precursor Cell Proliferation Arrest -- 4.3 The SC Secretome -- 4.4 Fibrosis -- References -- 5: The Nonfatal Clinical Manifestations of Ageing -- 5.1 Hair, Skin, Adipose Tissue -- 5.2 Bones, Muscles, and Joints -- 5.3 General Conditions, Frailty Syndrome, Fluid Balance, Immune System -- 5.4 Biological Rhythms -- 5.5 The Senses and Sensitivity -- References -- 6: Age-Linked Non-Transmissible Diseases -- 6.1 Cancers -- 6.2 Neurodegenerative Diseases -- 6.3 Type 2 Diabetes and Metabolic Syndrome -- 6.4 Lungs, Kidneys and Liver Diseases -- 6.5 The Senescent CV System -- 6.5.1 The Senescent Myocardium -- 6.5.2 The Senescent Vascular System -- 6.5.3 Consequences of Change in Characteristic Arterial Impedance -- 6.5.4 The Clinical Manifestations of Atherosclerosis -- 6.5.5 Heart Failure in Senescence -- 6.5.6 Atrial Fibrillation -- References -- 7: How to Treat or Prevent, or Slow Down, Cellular Ageing and Senescence? -- 7.1 The Various Attempts at Reprogramming -- 7.2 Calorie Restriction -- 7.3 Physical Exercise -- References -- 8: Senescence: A Darwinian Evolutionary Perspective.
