A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG
[EN] Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process. ; The authors gratefully acknowledge financial support from the Spanish Government (projects RTI2018-100910-B-C41 and RTI2018-101599-B-C22 (MCUI/AEI/FEDER,UE)), the Generalitat Valenciana (Project PROMETEO2018/024) and the European Union (Programme European Union Action 2-Erasmus Mundus Partnerships, Grant Agreement Number-2014-0870/001-001). A.H.-M. thanks the Erasmus Mundus Programme for his PhD scholarship for the EuroInkaNet project. ; Hernández-Montoto, A.; Gorbe, M.; Llopis-Lorente, A.; Terrés-Haro, JM.; Montes-Robles, R.; Cao Milán, R.; Díaz De Greñu-Puertas, B. (2019). A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG. Chemical Communications. 55(61):9039-9042. https://doi.org/10.1039/c9cc04260a ; S ; 9039 ; 9042 ; 55 ; 61 ; Koutsopoulos, S. (2012). Molecular fabrications of smart nanobiomaterials and applications in personalized medicine. Advanced Drug Delivery Reviews, 64(13), 1459-1476. doi:10.1016/j.addr.2012.08.002 ; Bao, G., Mitragotri, S., & Tong, S. (2013). Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging. Annual Review of Biomedical Engineering, 15(1), 253-282. doi:10.1146/annurev-bioeng-071812-152409 ; Descalzo, A. B., Martínez-Máñez, R., Sancenón, F., Hoffmann, K., & Rurack, K. (2006). The Supramolecular Chemistry of Organic–Inorganic Hybrid Materials. Angewandte Chemie International Edition, 45(36), 5924-5948. doi:10.1002/anie.200600734 ; Ariga, K., Ishihara, S., Labuta, J., & P. Hill, J. (2011). Supramolecular Approaches to Nanotechnology: Switching Properties and Dynamic Functions. Current Organic Chemistry, 15(21), 3719-3733. ...