Suchergebnisse

Deals with the negotiations in the United Kingdom which provided the structure and process that made the resettlement of Polish ex-servicemen in Canada possible. Further analyzes the selection process in Italy and the United Kingdom which resulted in Poles being accepted for resettlement. (Original abstract-amended)

The paper quantifies the relative manpower costs of the public building programs of the Julio-Claudian emperors of Rome from 29 b.c. to a.d. 68. We used both literary and archaeological sources for obtaining our data. Upon charting the data we discovered that the manpower needs show two peaks, one between 12 b.c. and 3 b.c., the other from a.d. 38–51.

Yes ; The prevalence of Type 2 diabetes mellitus (T2DM) is escalating globally. Patients suffer from multiple complications including the development of chronic wounds that can lead to amputation. These wounds are characterised by an inflammatory environment including elevated tumour necrosis factor alpha (TNF-α). Dermal fibroblasts (DF) are critical for effective wound healing, so we sought to establish whether there were any differences in DF cultured from T2DM donors or those without diabetes (ND-DF). ND- and T2DM-DF when cultured similarly in vitro secreted comparable concentrations of TNF-α. Functionally, pre-treatment with TNF-α reduced the proliferation of ND-DF and transiently altered ND-DF morphology; however, T2DM-DF were resistant to these TNF-α induced changes. In contrast, TNF-α inhibited ND- and T2DM-DF migration and matrix metalloprotease expression to the same degree, although T2DM-DF expressed significantly higher levels of tissue inhibitor of metalloproteases (TIMP)-2. Finally, TNF-α significantly increased the secretion of pro-inflammatory cytokines (including CCL2, CXCL1 and SERPINE1) in ND-DF, whilst this effect in T2DM-DF was blunted, presumably due to the tendency to higher baseline pro-inflammatory cytokine expression observed in this cell type. Collectively, these data demonstrate that T2DM-DF exhibit a selective loss of responsiveness to TNF-α, particularly regarding proliferative and secretory functions. This highlights important phenotypic changes in T2DM-DF that may explain the susceptibility to chronic wounds in these patients. ; This study was funded by an Iraqi government studentship to AHAA-R.