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"The Labour Church was an organisation fundamental to the British socialist movement during the formative years of the Independent Labour Party (ILP) and Labour Party between 1891 and 1914. It was founded by the Unitarian Minister John Trevor in Manchester in 1891 and grew rapidly thereafter. Its political credentials were on display at the inaugural conference of the ILP in 1893, and the Labour Church proved a formative influence on many pioneers of British socialism. This book provides an analysis of the Labour Church, its religious doctrine, its socio-political function and its role in the cultural development of the early socialist arm of the labour movement. It includes a detailed examination of the Victorian morality and spirituality upon which the life of the Labour Church was built. Jacqui Turner challenges previously held assumptions that the Labour Church was irreligious and merely a political tool. She provides a new cultural picture of a diverse and inclusive organisation, committed to individualism and an individual relationship with God. As such, this book brings together two major controversies of late-Victorian Britain: the emergence of independent working-class politics and the decline of traditional religion in a work which will be essential reading for all those interested in the history of the labour movement."--

INTRODUCTION: Inherited retinal degenerations (IRD) are rare genetic disorders with > 300 known genetic loci, manifesting variably progressive visual dysfunction. IRDs were historically underserved due to lack of effective interventions. Many novel therapies will require accurate diagnosis (phenotype and genotype), thus an efficient and effective pathway for assessment and management is required. METHODS: Using surveys of existing practice patterns and advice from international experts, an all-Ireland IRD service (Target 5000) was designed. Detailed phenotyping was followed by next generation genetic sequencing in both a research and accredited laboratory. Unresolved pedigrees underwent further studies (whole gene/whole exome/whole genome sequencing). Novel variants were interrogated for pathogenicity (cascade screening, in silico analysis, functional studies). A multidisciplinary team (MDT; ophthalmologists, physicians, geneticists, genetic counsellors) reconciled phenotype with genotype. A bespoke care plan was created for each patient comprising supports, existing interventions, and novel therapies/clinical trials. RESULTS AND DISCUSSION: Prior to Target 5000, a significant cohort of patients were not engaged with healthcare/support services due to lack of effective interventions. Pathogenic or likely pathogenic variants in IRD-associated genes were detected in 62.3%, with 11.6% having variants of unknown significance. The genotyping arm of Target 5000 allowed a 42.73% cost saving over independent testing, plus the value of MDT expertise/processing. Partial funding has transferred from charitable sources to government resources. CONCLUSION: Target 5000 demonstrates efficacious and efficient clinical/genetic diagnosis, while discovering novel IRD-implicated genes/variants and investigating mechanisms of disease and avenues of intervention. This model could be used to develop similar IRD programmes in small/medium-sized nations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material ...