Dioxin - contemporary and future challenges of historical legacies
In: Environmental science and pollution research: ESPR, Band 15, Heft 2, S. 96-100
ISSN: 1614-7499
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In: Environmental science and pollution research: ESPR, Band 15, Heft 2, S. 96-100
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 15, Heft 2, S. 95-95
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 6, Heft 3, S. 126-126
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 4, Heft 2, S. 75-81
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 15, Heft 6, S. 463-471
ISSN: 1614-7499
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 170, S. 644-656
ISSN: 1090-2414
In: Environmental science and pollution research: ESPR, Band 16, Heft 4, S. 396-409
ISSN: 1614-7499
The general European population has a total intake of dioxins and dioxin-like chemicals near the limit recommended by the European Union, making additional exposure above background levels undesirable. For populations living near dioxin contaminated sites additional exposure may occur by intake of locally produced food, inhalation of particles, dermal contact with soils, or by other exposure pathways. Risk assessment tools are required to estimate risks associated with contaminated sites and to set priorities for site remediation. Here, we review several multimedia models that can be applied as tools to support risk assessment. We then and present a strategy to select, apply, evaluate and adapt a model to address a specific situation. The case study we consider is a risk assessment of generic background dioxin exposure in Sweden, and we compare the predictions with environmental observations and exposure data from Sweden. Arguments are presented for selecting the CalTOX model for this case study. We demonstrate the application, evaluation and adaptation of the model, and discuss the requirements for extending the analysis to conduct risk assessment for subpopulations living near dioxin contaminated sites.
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In: Environmental science and pollution research: ESPR, Band 13, Heft 3, S. 161-169
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 17, Heft 1, S. 26-39
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 4, Heft 4, S. 188-188
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 2, Heft 2, S. 73-82
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 2, Heft 4, S. 211-216
ISSN: 1614-7499
In: Environmental sciences Europe: ESEU, Band 31, Heft 1
ISSN: 2190-4715
This paper presents 10 recommendations for improving the European Medicines Agency's guidance for environmental risk assessment of human pharmaceutical products. The recommendations are based on up-to-date, available science in combination with experiences from other chemical frameworks such as the REACH-legislation for industrial chemicals. The recommendations concern: expanding the scope of the current guideline; requirements to assess the risk for development of antibiotic resistance; jointly performed assessments; refinement of the test proposal; mixture toxicity assessments on active pharmaceutical ingredients with similar modes of action; use of all available ecotoxicity studies; mandatory reviews; increased transparency; inclusion of emission data from production; and a risk management option. We believe that implementation of our recommendations would strengthen the protection of the environment and be beneficial to society. Legislation and guidance documents need to be updated at regular intervals in order to incorporate new knowledge from the scientific community. This is particularly important for regulatory documents concerning pharmaceuticals in the environment since this is a research field that has been growing substantially in the last decades.
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