Nanoengineering palladium plasmonic Nanosheets inside polymer nanospheres for photothermal therapy and targeted drug delivery
The incorporation of plasmonic nanoconstructs in biodegradable polymeric nanoparticles (NPs), together with therapeutic drugs in a controlled procedure is of interest for different applications in Nanomedicine. Advanced hybrid nanomaterials can be engineered by combining the in situ formation of plasmonic palladium nanosheets (NSs) and the proper ionic nature of the encapsulated drug. This study presents a new procedure to synthesize hybrid nanostructures by a Pickering double emulsion. Anisotropic palladium (Pd) NSs with unique near-infrared (NIR)-optical properties can be assembled within a poly lactic-co-glycolic acid matrix of REF: RTI2018-099019-A-I00. R.A. acknowledges funding from the Spanish MICINN (project grant PID2019-104739GB-100/AEI/10.13039/501100011033), from the Government of Aragon (project DGA E13-20R), and from the European Union H2020 program "ESTEEM3" (No. 823717). ; Peer reviewed