Suchergebnisse

"Exploratory analysis of family organization, collective identity, and religious culture in diocese of Ciudad Guzmán contends that a resurgence of cultural manifestations and popular religion, influenced by the Catholic Church, has taken place in the region despite economic and political disarticulation. Based on 207 questionnaires administered in 23 towns"--Handbook of Latin American Studies, v. 57

Luis II de Borbón, conocido como el Grand Condé, es uno de los principales nobles y jefes de armas de la Historia de Francia. Sin embargo, sus años de alianza con España, que abarcan su intervención en la Fronda y su exilio en Flandes (1651-1659), no han gozado de suficiente atención por parte de los investigadores. Interesa ahora la representación construida en torno a su figura, en el corazón de la Monarquía Hispánica: el reino de Castilla y, particularmente, la corte madrileña, es decir, en el centro del poder. Aquí se analizan la visión que sobre él se tenía en el círculo cortesano, con don Luis de Haro a la cabeza; el importante papel jugado, en su conformación, por los agentes del Príncipe enviados a Madrid; y, por último, su transmisión a la incipiente opinión pública mediante los impresos de relaciones de sucesos. El héroe de Rocroi acabó revestido de una imagen gloriosa, similar a la que todavía le otorga buena parte de la historiografía francesa cuando trata sus años de exilio. Algo nada baladí, pues contribuye a explicar el apoyo que disfrutó de Felipe IV, hasta la firma de la Paz de los Pirineos.

Louis II of Bourbon, known as the Grand Condé, remains one of the great noblemen and military commanders in the history of France. His years of alliance with Spain, however, extending from his participation in the Fronde and his exile in the Habsburg Netherlands (1651-1659), have received little attention from scholars. This paper looks at how he was represented and understood in the heart of the Spanish Monarchy, in the kingdom of Castile and, above all, in the Madrid court, the centre of power. It analyses the vision of him in the court, where don Luis de Haro was the leading statesman; it also looks at the important role played by Condé's agents in shaping his image in Madrid; lastly, it examines how he was projected into the incipient public opinion through the relaciones de sucesos. In Castile the hero of Rocroi was cast as a heroic figure, similar in nature to the position he enjoys in much French historiography dealing with his years of exile. His status and popularity helps to explain the help that he received from Philip IV until the Peace of the Pyrenees (1659). ; Luis II de Borbón, conocido como el Grand Condé, es uno de los principales nobles y jefes de armas de la Historia de Francia. Sin embargo, sus años de alianza con España, que abarcan su intervención en la Fronda y su exilio en Flandes (1651-1659), no han gozado de suficiente atención por parte de los investigadores. Interesa ahora la representación construida en torno a su figura, en el corazón de la Monarquía Hispánica: el reino de Castilla y, particularmente, la corte madrileña, es decir, en el centro del poder. Aquí se analizan la visión que sobre él se tenía en el círculo cortesano, con don Luis de Haro a la cabeza; el importante papel jugado, en su conformación, por los agentes del Príncipe enviados a Madrid; y, por último, su transmisión a la incipiente opinión pública mediante los impresos de relaciones de sucesos. El héroe de Rocroi acabó revestido de una imagen gloriosa, similar a la que todavía le otorga buena parte de la historiografía francesa cuando trata sus años de exilio. Algo nada baladí, pues contribuye a explicar el apoyo que disfrutó de Felipe IV, hasta la firma de la Paz de los Pirineos.

In the Old Regime, even abandoned by the court in 1606, Valladolid was a second court, as seat of the Royal Chancery. This study focuses on the impact caused by the Chancery in the town and its surroundings -the five leagues−, through criminal judges. They were superior judges in criminal cases and they had other responsibilities in justice, government and police. So there were frequent conflicts with various urban institutions. Moreover, criminal judges expanded and strengthened their power in the second half of the eighteenth century, during the Enlightenment, and they became the highest guarantors of public order in Valladolid. ; En el Antiguo Régimen, aun abandonada por la corte en 1606, Valladolid era una segunda corte, como sede de la Real Chancillería. Este estudio se centra en el impacto causado por la Chancillería en la ciudad y su contorno -las cinco leguas−, a través de los alcaldes del crimen. Eran jueces superiores en materia criminal y reunían además otras competencias en asuntos de justicia, gobierno y policía, por lo que fueron frecuentes los conflictos con diversas instituciones urbanas. Es más, las facultades de los alcaldes del crimen se ampliaron y reforzaron en la segunda mitad del siglo XVIII, en tiempos de la Ilustración, erigiéndose definitivamente en los máximos garantes del orden público en la capital del Pisuerga.

Articulo del Dossier ; En el Antiguo Régimen, aun abandonada por la corte en 1606, Valladolid era una segunda corte, como sede de la Real Chancillería. Este estudio se centra en el impacto causado por la Chancillería en la ciudad y su contorno -las cinco leguas−, a través de los alcaldes del crimen. Eran jueces superiores en materia criminal y reunían además otras competencias en asuntos de justicia, gobierno y policía, por lo que fueron frecuentes los conflictos con diversas instituciones urbanas. Es más, las facultades de los alcaldes del crimen se ampliaron y reforzaron en la segunda mitad del siglo XVIII, en tiempos de la Ilustración, erigiéndose definitivamente en los máximos garantes del orden público en la capital del Pisuerga. ; In the Old Regime, even abandoned by the court in 1606, Valladolid was a second court, as seat of the Royal Chancery. This study focuses on the impact caused by the Chancery in the town and its surroundings -the five leagues−, through criminal judges. They were superior judges in criminal cases and they had other responsibilities in justice, government and police. So there were frequent conflicts with various urban institutions. Moreover, criminal judges expanded and strengthened their power in the second half of the eighteenth century, during the Enlightenment, and they became the highest guarantors of public order in Valladolid.

Here, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis (IA). We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium. The meta-analysis of the discovery and replication populations revealed that carriers of the TNFSF4 rs7526628T/T genotype had a significantly increased risk of developing IA ( p = 0.00022). We also found that carriers of the TNFSF4 rs7526628T allele showed decreased serum levels of TNFSF14 protein ( p = 0.0027), and that their macrophages had a decreased fungicidal activity ( p = 0.048). In addition, we observed that each copy of the MAPKAPK2 rs12137965G allele increased the risk of IA by 60% ( p = 0.0017), whereas each copy of the MAPKAPK2 rs17013271T allele was estimated to decrease the risk of developing the disease ( p = 0.0029). Mechanistically, we found that carriers of the risk MAPKAPK2 rs12137965G allele showed increased numbers of CD38+IgM-IgD- plasmablasts in blood ( p = 0.00086), whereas those harboring two copies of the allele had decreased serum concentrations of thymic stromal lymphopoietin ( p = 0.00097). Finally, we also found that carriers of the protective MAPKAPK2 rs17013271T allele had decreased numbers of CD27-IgM-IgD- B cells ( p = 0.00087) and significantly lower numbers of CD14+ and CD14+CD16- cells ( p = 0.00018 and 0.00023). Altogether, these results suggest a role of the TNFSF4 and MAPKAPK2 genes in determining IA risk. ; This study was supported by grants PI20/01845, PI12/02688, and ISCIII-FEDER PI17/02276 from Fondo de Investigaciones Sanitarias (Madrid, Spain), PIM2010EPA-00756 from the ERA-NET PathoGenoMics (0315900A), the Collaborative Research Center/Transregio 124 FungiNet, the Fundacao para a Ciencia e Tecnologia (FCT) (PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, CEECIND/03628/2017, and CEECIND/04058/2018), the European Union's Horizon ...

Here, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis (IA). We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium. The meta-analysis of the discovery and replication populations revealed that carriers of the TNFSF4rs7526628T/T genotype had a significantly increased risk of developing IA (p = 0.00022). We also found that carriers of the TNFSF4rs7526628T allele showed decreased serum levels of TNFSF14 protein (p = 0.0027), and that their macrophages had a decreased fungicidal activity (p = 0.048). In addition, we observed that each copy of the MAPKAPK2rs12137965G allele increased the risk of IA by 60% (p = 0.0017), whereas each copy of the MAPKAPK2rs17013271T allele was estimated to decrease the risk of developing the disease (p = 0.0029). Mechanistically, we found that carriers of the risk MAPKAPK2rs12137965G allele showed increased numbers of CD38+IgM-IgD- plasmablasts in blood (p = 0.00086), whereas those harboring two copies of the allele had decreased serum concentrations of thymic stromal lymphopoietin (p = 0.00097). Finally, we also found that carriers of the protective MAPKAPK2rs17013271T allele had decreased numbers of CD27-IgM-IgD- B cells (p = 0.00087) and significantly lower numbers of CD14+ and CD14+CD16- cells (p = 0.00018 and 0.00023). Altogether, these results suggest a role of the TNFSF4 and MAPKAPK2 genes in determining IA risk. ; This study was supported by grants PI20/01845, PI12/02688, and ISCIII-FEDER PI17/02276 from Fondo de Investigaciones Sanitarias (Madrid, Spain), PIM2010EPA-00756 from the ERA-NET PathoGenoMics (0315900A), the Collaborative Research Center/Transregio 124 FungiNet, the Fundação para a Ciência e Tecnologia (FCT) (PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, CEECIND/03628/2017, and CEECIND/04058/2018), the European Union's Horizon 2020 research ...