Article(electronic)#1January 7, 2017
Modeling Risk for Intimate Partner Violence among Recent-Era Veteran-Partner Dyads
In: Journal of family violence, Volume 32, Issue 5, p. 505-512
ISSN: 1573-2851
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Article(electronic)#2May 2019
Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans
In: Psychological services, Volume 16, Issue 2, p. 312-320
ISSN: 1939-148X
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Article(electronic)#3November 2021
Psychological outcomes following sexual assault: Differences by sexual assault setting
In: Psychological services, Volume 18, Issue 4, p. 504-511
ISSN: 1939-148X
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Open Access#42020
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Smith, Alicia K; Ratanatharathorn, Andrew; Maihofer, Adam X; Naviaux, Robert K; Aiello, Allison E; Amstadter, Ananda B; Ashley-Koch, Allison E; Baker, Dewleen G
Smith, Alicia K; Ratanatharathorn, Andrew; Maihofer, Adam X; Naviaux, Robert K; Aiello, Allison E; Amstadter, Ananda B; Ashley-Koch, Allison E; Baker, Dewleen G; Beckham, Jean C; Boks, Marco P; Bromet, Evelyn; Dennis, Michelle; Galea, Sandro; Garrett, Melanie E; Geuze, Elbert; Guffanti, Guia; Hauser, Michael A; Katrinli, Seyma; Kilaru, Varun; Kessler, Ronald C; Kimbrel, Nathan A; Koenen, Karestan C; Kuan, Pei-Fen; Li, Kefeng; Logue, Mark W; Lori, Adriana; Luft, Benjamin J; Miller, Mark W; Naviaux, Jane C; Nugent, Nicole R; Qin, Xuejun; Ressler, Kerry J; Risbrough, Victoria B; Rutten, Bart PF; Stein, Murray B; Ursano, Robert J; Vermetten, Eric; Vinkers, Christiaan H; Wang, Lin; Youssef, Nagy A; INTRuST Clinical Consortium; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup; Uddin, Monica; Nievergelt, Caroline M
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with PTSD and suggests a role for decreased kynurenine as a contributor to immune dysregulation in PTSD.
BASE
Open Access#52020
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Smith, Alicia K; Ratanatharathorn, Andrew; Maihofer, Adam X; Naviaux, Robert K; Aiello, Allison E; Amstadter, Ananda B; Ashley-Koch, Allison E; Baker, Dewleen G
Smith, Alicia K; Ratanatharathorn, Andrew; Maihofer, Adam X; Naviaux, Robert K; Aiello, Allison E; Amstadter, Ananda B; Ashley-Koch, Allison E; Baker, Dewleen G; Beckham, Jean C; Boks, Marco P; Bromet, Evelyn; Dennis, Michelle; Galea, Sandro; Garrett, Melanie E; Geuze, Elbert; Guffanti, Guia; Hauser, Michael A; Katrinli, Seyma; Kilaru, Varun; Kessler, Ronald C; Kimbrel, Nathan A; Koenen, Karestan C; Kuan, Pei-Fen; Li, Kefeng; Logue, Mark W; Lori, Adriana; Luft, Benjamin J; Miller, Mark W; Naviaux, Jane C; Nugent, Nicole R; Qin, Xuejun; Ressler, Kerry J; Risbrough, Victoria B; Rutten, Bart PF; Stein, Murray B; Ursano, Robert J; Vermetten, Eric; Vinkers, Christiaan H; Wang, Lin; Youssef, Nagy A; INTRuST Clinical Consortium; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup; Uddin, Monica; Nievergelt, Caroline M
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with PTSD and suggests a role for decreased kynurenine as a contributor to immune dysregulation in PTSD.
BASE