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v. 1. Revolutions of race.--v. 2. Revolutions in religion.--v. 3. Revolutions in government. ; Mode of access: Internet.

v. 2: London, Parker, son, and Bourn, 1861; v. 3: London, Longman, Green, Longman, Roberts, & Green, 1863. ; v. 1. Revolutions of race.--v. 2. Revolutions in religion.--v. 3. Revolutions in government. ; Mode of access: Internet.

Vol. 3 has imprint: London : Longman, Green, Longman, Roberts, & Green, 1863. ; Vol. 2 has imprint: London : Parker, Son, and Bourn, 1861. ; Includes bibliographical references. ; v. 1. Revolutions of race -- v. 2. Revolutions in religion -- v. 3. Revolutions in government. ; Mode of access: Internet.

[15], 202, [12], 122 p. : port. ; Sir Walter Raleigh's portrait signed: Ro. Vaughan. ; "A mere reissue of the 'Maxims of state,' 1656 (Wing R176), with the omission of the 'Observations touching trade and commerce with the Hollander,' and the addition of 'The prerogative of parliaments'"--Sabin 67577. Includes the t.p. of the 1656 edition of "Maxims of state." ; Reproduction of original in British Library. ; (from t.p.) Maxims of state -- Advise to his son : his sons advise to his father -- His Sceptick -- Observation concerning the causes of the magnificencie and opulency of cities -- His letters to divers persons of quality -- The prerogative of parliaments.

[44], 363, [1] p. : ill. (metal cuts) ; A translation of: De cive. ; With an additional title page, engraved, "Philosophicall rudiments concerning goverment and civill society", signed "Ro: Vaughan sculp:". Variant (probably earlier): this title page in another engraving, "Philosophicall elements of goverment and civill society". ; Annotation on Thomason copy: "march. 12· 1650"; the 51 in the imprint date has been crossed out. ; Reproduction of the original in the British Library.

[8], 80 p. : port. ; Portrait engraved by Ro. Vaughan. ; Reproduction of original in Yale University Library. ; "The seat of government": p. 65-71; "Observations concerning the causes of the magnificency and opulency of cities": p. 73-76; "Safety for defence of the people and their goods": p. 77-80.

Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application.

Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application.