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Početak razvoja Kliničkoga bolničkog centra u Osijeku vezanje uz Huttler Kohlhoffer Monspergerovu zakladnu bolnicu, osnovanu 1874. godine, koja je tada bila najmodernija bolnica na jugoistoku Europe. Naredbom Vlade 1895. godine postaje "Sveobća i javna Huttler Kohlhoffer-Monspergerova zakladna bolnica pod Zemaljskom upravom u Osieku". U vrijeme Prvoga svjetskog rata Zakladna bolnica skrbi o ranjenima i bolesnima. Poslije Prvoga svjetskog rata otvaraju se novi bolnički odjeli. Osim Kirurgije i Interne medicine, novi su odjeli Oftalmologija, Otorinolaringologija, Dermatovenerologija, Epidemiološkohigijenski zavod i Dispanzer za tuberkulozu. Daljnji razvoj prekinuo je Drugi svjetski rat. U teškim prilikama razvijen je poseban način medicinskoga rada, osobito u pogledu zbrinjavanja ranjenika i bolesnika, poduzimanja protuepidemijskih mjera, medicinskog opskrbljivanja i si. Nakon Drugoga svjetskog rata obnavlja se Opća bolnica Osijek i započinje moderan ustroj kao temelj razvoja buduće kliničke bolnice. U razdoblju 1980. - 1990. godine provode se stručna usavršavanja na svim područjima, objavljuju se brojni znanstveni i stručni radovi, razvija izdavačka djelatnost, što pridonosi stvaranju obrazovno nastavne djelatnosti i znanstveno-istraživačkoga rada. Posebno treba istaknuti razdoblje Domovinskoga rata u kojem je bolnica časno izvršila sve svoje zadaće u liječenju ranjenih i bolesnih. Stoga joj je dodijeljena nagrada "Medicina . Godine 1992. stekla je naslov Klinička bolnica Osijek. Daljnjim razvojem, izgradnjom, opremanjem i napredovanjem djelatnika u znanstvena, nastavna, znanstveno nastavna i stručna zvanja, 2009. godine postaje Klinički bolnički centar. Klinike i odjeli Kliničkoga bolničkog centra u Osijeku nastavna su baza Medicinskoga fakulteta Sveučilišta J. J. Strossmayera u Osijeku. ; Beginnings of the University Hospital Centre in Osijek were related to Huttler Kohlhoffer Monsperger Foundation Hospital, which was founded in 1874 and was the most modern hospital in the south-east Europe at the time. By the Government legislation in 1895 it became "General and public Huttler Kohlhoffer Monsperger Foundation Hospital under Country's management in Osiek". Foundation hospital was taking care of the wounded and sick during the World War 1. New hospital departments were opened after the World War I. Apart from Surgery and Internal Department; new departments were Ophthalmology, Otorhinolaryngology, Dermatovenereology, Epidemiological and Hygienic Institute and Tuberculosis Clinic. Further development was interrupted by the World War II. A special way of performing medical work developed in those hard times, especially regarding taking care of the wounded and sick, taking epidemic precaution measures, medical supplying, etc. After the World War II General Hospital Osijek was renovated and modern organization began, which was a basis for development of the future university hospital. In the period 1980 - 1990 professional educations in all areas were implemented, many scientific and professional papers were published, publishing developed, what contributed to creating educational and teaching activities, as well as scientific and research work. Period of the War for Croatian Independence, in which the hospital honourably performed all its duties regarding treating wounded and sick, especially needs to be pointed out. For those activities it was rewarded with "Medicine" reward. In 1992 it became University Hospital Osijek. By further development, construction, and equipment and by promoting its employees to scientific, teaching, scientific teaching and professional titles, it became University Hospital Centre in 2009. Clinics and Departments of the University Hospital Centre in Osijek are the teaching base of the Faculty of Medicine, Josip Juraj Strossmayer University of Osijek.