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Kundenbindung in Autohaus und Werkstatt: wie Sie Kunden dauerhaft binden
In: Marketing, Verkauf
In: Auto-Service-Praxis
Erfolgsfaktor Servicemarketing: so kommen Kunden in die Werkstatt
In: Servicekompetenz
In: Autohaus Buch & Formular
Aktiver Serviceverkauf: [die Dialogannahme in der Praxis ; mit Mustern und Checklisten]
In: Fahrzeugcheck
In: Business-Profi
In: Autohaus
In: Auto-Service-Praxis
PERSONAL & FÜHRUNG: Die Vorgesetztenbeurteilung als vertrauensbildende Maßnahme
In: Innovative Verwaltung: IV : das Fachmedium für erfolgreiches Verwaltungsmanagement, Band 30, Heft 9, S. 30-33
ISSN: 1618-9876
Beamtenrecht: mit Grundzügen des Personalvertretungsrechts
In: Sächsische Lehrbriefe 8 B
Polizei- und Gewerberecht
In: Reihe Sächsische Lehrbriefe 9
Die Werkstatt-Zukunft: Betriebe führen, Wandel gestalten
In: Unternehmensführung
Personalwesen
In: Sächsische Lehrbriefe SL 8
Role of bulge epidermal stem cells and TSLP signaling in psoriasis
Psoriasis is a common inflammatory skin disease involving a cross-talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF-SCs) in psoriasis is not well defined. Here, we show reduced expression of c-JUN and JUNB in bulge HF-SCs in patients with scalp psoriasis. Using lineage tracing in mouse models of skin inflammation with inducible deletion of c-Jun and JunB, we found that mutant bulge HF-SCs initiate epidermal hyperplasia and skin inflammation. Mechanistically, thymic stromal lymphopoietin (TSLP) was identified in mutant cells as a paracrine factor stimulating proliferation of neighboring non-mutant epidermal cells, while mutant inter-follicular epidermal (IFE) cells are lost over time. Blocking TSLP in psoriasis-like mice reduced skin inflammation and decreased epidermal proliferation, VEGFα expression, and STAT5 activation. These findings unravel distinct roles of HF-SCs and IFE cells in inflammatory skin disease and provide novel mechanistic insights into epidermal cell interactions in inflammation. ; We thank Drs. M. Serrano and M. Perez-Moreno for the Gt(ROSA)26Sortrn4(ACTB-tdTomato,-EGFP)Luo/J and K15-Cre-PGR mouse lines. We are very grateful to Drs. M. Perez-Moreno, F. Real, O. Uluckan, L. Bakiri and the laboratory members of the Sibilia and Wagner groups for critical reading of the manuscript and valuable suggestions. We thank V. Bermeo, G. Medrano, S. Leceta, O. Grana, and M. Perez for their technical help and IT support. We acknowledge R. Paus laboratory members for the shipment of hair follicle samples. N.G.L. received funding from the People programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 608765. A.I is funded by the Institute of Health Carlos III (PI16/01430). The Wagner laboratory was funded by a grant from the Spanish Ministry of Economy and competitiveness (SAF2015-70857RE, cofounded by the European Regional Development Fund) and is ...
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