Suchergebnisse

Background Melanoma incidence often shows an increasing latitudinal gradient from north to south among white European populations. Objectives To assess emerging regional melanoma incidence patterns in England. Methods All primary invasive cutaneous melanomas diagnosed in England in people aged 10-89 years, in 1996-2006, were ascertained. Age-standardized incidence rates by sex, age and Government Office Region were calculated for the entire population and for the white population only. Rates according to socioeconomic deprivation were further calculated among those aged under 30 years. Regional heterogeneity and latitude and deprivation trends were assessed by Poisson regression and tests for trend. Results Overall, melanoma incidence in England was highest in the South West (overall, 18·75; white, 19·03 per 100 000) and lowest in London (overall, 8·85; white, 11·22 per 100 000). Incidence significantly increased with more southerly latitudes in all white adults aged over 30 years (P <0·0001), except women aged 30-49 years (1·8%, P = 0·10). However, these north-south latitude trends were reversed in white 10-29 year olds, with sex-specific analyses showing an absence of trend in male subjects (2·7%, P = 0·41) and a strong decreasing trend (-9·8%, P <0·0001) in female subjects. The highest rates in the young female population occurred in the North West (5·46 per 100 000), and specifically in the second most deprived (5·69 per 100 000) and the second most affluent (6·48 per 100 000) groups. Conclusions Melanoma incidence is high in young people in northern England, including among the moderately deprived, reversing the expected north-south incidence gradients. Prevalent sunbed use in northern England and holiday sun exposure abroad may explain these emerging trends. What's already known about this topic? Increasing trends in melanoma incidence from north to south have been noted in England and other northern countries. Melanoma predominantly affects white, affluent populations; however, neither ethnic groups nor socioeconomic status are uniformly distributed across England. What does this study add? This study describes a striking reversal in the well-established north-south latitude trend in melanoma incidence among young women in England. Incidence was high among young people in northern regions, and particularly among moderately deprived female subjects. © 2013 British Association of Dermatologists.