Suchergebnisse

Wind power (WP) is a long-term strategic energy alternative for China to cope with energy shortage and environmental crisis. Yet, how innovation policies precisely affect innovation efficiency (IE) of WP industry remains poorly understood. Therefore, based on the micro-data of Chinese WP-listed companies, this article measures the IE of enterprises in different links of wind power industry chain (WPIC), and discusses the effects of innovation policy and its mix on IE. The results show that there exists non-efficiency problems in Chinese WP industry during 2014–7, but the innovation of enterprises in the upstream of WPIC is DEA efficient. IE of enterprises in the midstream presents a U-shape, which fluctuates periodically in downstream. In addition, neither a single policy nor a policy mix has a significant impact on IE of enterprises in the upstream and midstream of WPIC, but has a significant negative effect on that of the downstream.

Shurui Zhao,1 Ze Li,1 Fei Huang,2 Jianhui Wu,1 Lin Gui,1 Xiaoyi Zhang,1 Yaonan Wang,1 Xiaozhen Wang,1 Shiqi Peng,1 Ming Zhao11Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China; 2Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of ChinaBackground: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine.Methods: MTCA-KKV was characterized by nano-feature, anti-thrombotic activity, thrombolytic activity, thrombus target and targeting release.Results: In vivo 0.01 μmol/kg of MTCA-KKV formed nano-particles less than 100 nm in diameter, targeted thrombus, released anti-thrombotic and thrombolytic pharmacophores, prevented thrombosis and dissolved blood clots.Conclusion: Based on the profiles of targeting thrombus, targeting release, inhibiting thrombosis and dissolving blood clots MTCA-KKV is a promising nano-medicine.Keywords: nano-particles, anti-thrombotic, thrombolytic, targeting, release