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With the extensive development of the economy, environmental degradation has become a serious global issue. How to ensure the sustainable development of regional environments has drawn widespread attention from governments, academia, and the public. As an index to measure the efficiency of financial expenditure on the environment by local governments, the assets and environmental liabilities conversion rate (AELCR), along with the spatial pattern changes it presents and the factors it is affected by, is worthy of in-depth study. This study took the AELCRs of 31 provinces in China from 2012 to 2017 as the research objects, analyzed their spatial patterns and evolution using GeoDa software, and explored their spatial distribution using a spatial econometric model. The results show that, on the whole, China's provinces were characterized by unbalanced economic development and large gaps in development levels, and there were significant differences in the efficiencies of fiscal expenditure for environmental protection between regions. Overall, there was a negative correlation between China's neighboring provinces, and there was strong heterogeneity between provinces with a low conversion efficiency and the surrounding provinces. Locally, most provinces did not show significant spatial correlation, while the local similarities of the AELCRs decreased from 2012 to 2017, and the heterogeneities increased. Through the analysis of influencing factors, it was found that the urbanization level and provincial R& ; D investment positively increased the AELCRs, where the positive impact of urbanization was more obvious ; resource tax and urban infrastructure investment were negatively correlated with the conversion rates, and the negative impact of resource tax was greater. The findings of this study provide important theoretical and practical implications for local governments to reasonably allocate environmental expenditure and improve their conversion rate of assets and environmental liabilities.

Drawing on the literature on perceived illegitimate tasks, we investigated, with 216 participants, how temporal leadership affects employee workplace deviance. Our findings show that temporal leadership effectively reduced employee workplace deviance. In addition, perceived illegitimate tasks played a mediating role in the relationship between temporal leadership and employee workplace deviance, and goal congruence moderated the indirect effect of temporal leadership on employee workplace deviance through perceived illegitimate tasks. Practical implications and suggestions for future studies are discussed.

Women have become an increasingly important force in entrepreneurship, and their relatively low entrepreneurial competence has aroused widespread attention from the academia. Drawing from the resource-based theory and the social support theory, this study aims to explore the impact of Internet use on women's entrepreneurial competence and the roles of entrepreneurial resource acquisition and family support in this relationship. After collecting a sample of 328 women entrepreneurs in China, this study demonstrates that Internet use is positively related to women's entrepreneurial competence, and this relation is partially mediated by entrepreneurial resource acquisition. Moreover, family support moderates the relation between Internet use and entrepreneurial resource acquisition as well as the mediating effect of entrepreneurial resource acquisition. The results of the current study contribute to revealing how Internet use affects women's entrepreneurial competence, including its direct and indirect effects and boundary conditions. Practical implications for policy-makers and female entrepreneurs are also provided.

Jian Yang,1,* Jijie Yan,2,* Meihui Zeng,3,* Wei Wan,1 Tielong Liu,1 Jian-Ru Xiao1 1Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Ningbo University, Ningbo, Zhejiang, People's Republic of China; 3Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China*These authors contributed equally to this workCorrespondence: Tielong Liu; Jian-Ru Xiao Tel +8602181885634Fax +8602163720099Email hahameixinmeifei@163.com; jianruxiao82@163.comBackground: With the occurrence and improvement of immunohistochemistry and other pathological diagnostic techniques, gastrointestinal stromal tumor (GIST) has been gradually recognized. With the prolonged survival of patients with GISTs, reports about the bone metastasis of GIST increased. However, the knowledge of GISTs is rather limited due to its very low incidence.Methods: Cochrane and Medline database (via PubMed) were searched in July 2019 with related keywords to acquire the literature related to the bone metastasis of GIST. Then, the literature was reviewed and references were also scanned to identify the possible related reports. Study data comprising age, sex, primary location, metastasis interval time, immunohistochemistry index, management and prognosis were recorded and analyzed.Results: Forty-five patients with bone metastases of GIST, with a mean age of 61.09 years, were included. The small intestine and stomach were the most common primary sites, followed by the rectum. Patients with small intestine primary sites had bone metastases that occurred earlier than the bone metastases stomach and rectum primary sites. The spine was the most common site of bony metastases. The mean survival time after GIST diagnosis was more than 64.02 months. Patients younger than 60 years old had a worse prognosis than those older than 60 years old. Furthermore, patients with spinal involvement had a worse prognosis than those without spinal involvement. Surgical interventions combined with targeted therapies guaranteed a better prognosis.Conclusion: Bone metastasis of GIST, which mainly occurs in the spine, is rather rare. Patients with GISTs of the small intestine and stomach suffered from bone metastasis more frequently and earlier than patients with GISTs in other primary sites. Age, sex, primary tumor location, treatment mode for the primary lesions and metastases, and spine involvement may be potential factors that affect the prognosis of GIST patients with bone metastases.Keywords: gastrointestinal stromal tumor, bone metastasis, tyrosine kinase inhibitors, prognosis

Haiyun Zhang,1,* Yujie Liu,2,* Kehan Xu,2,* Kai Mao,1 Weidong Han,1 Feifan Xu,1 Wei Wan,2 Yajun Sun3 1Department of Laboratory Medicine, The Sixth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China; 2Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China; 3Department of Laboratory Medicine, The Fourth People's Hospital of Nantong, Jiangsu 226000, People's Republic of China*These authors contributed equally to this workCorrespondence: Yajun Sun; Wei WanDepartment of Laboratory Medicine, The Fourth People's Hospital of Nantong, Chenggang Road, Jiangsu 226000, People's Republic of ChinaEmail yajun_sun1@163.com; wei_wan66@163.comIntroduction: Amphiphysin 1 (AMPH-1) is involved in endocytosis, and its expression is upregulated in osteosarcoma compared with osteofibrous dysplasia.Methods: We investigated the role of AMPH-1 in osteosarcoma cells via both gain-of-function and loss-of-function experiments.Results: Knockdown of AMPH-1 in osteosarcoma cells promoted cell cycle progression and cell proliferation and attenuated apoptosis. Notably, silencing AMPH-1 increased osteosarcoma progression in a mouse tumor model. The results obtained upon AMPH-1 knockdown and AMPH-1 overexpression indicates that AMPH-1 is involved in regulating MEK/ERK signaling.Conclusion: These data suggest that AMPH-1 plays an important role in osteosarcoma and may represent a novel therapeutic target for osteosarcoma treatment.Keywords: AMPH-1, osteosarcoma, ERK signaling pathway

The synthesis of crystalline microporous materials containing large pores is in high demand by industry, especially for the use of these materials as catalysts in chemical processes involving bulky molecules. An extra-large-pore silicoaluminophosphate with 16-ring openings, ITQ-51, has been synthesized by the use of bulky aromatic proton sponges as organic structure-directing agents. Proton sponges show exceptional properties for directing extra-large zeolites because of their unusually high basicity combined with their large size and rigidity. This extra-large-pore material is stable after calcination, being one of the very few examples of hydrothermally stable molecular sieves containing extra-large pores. The structure of ITQ-51 was solved from submicrometer-sized crystals using the rotation electron diffraction method. Finally, several hypothetical zeolites related to ITQ-51 have been proposed. ; The authors gratefully acknowledge Dr. Alejandro Vidal-Moya for the SUP>27 /SUP>Al MQ MAS NMR experiment. The authors also acknowledge financial support from Ministerio de Economia y Competitividad of Spain (MAT2012-37160), Consolider Ingenio 2010-MULTICAT, Generalitat Valenciana through the PROMETEO program, Universitat Politecnica de Valencia through PAID-06-11 (n.1952), the Swedish Research Council (VR), the Swedish Governmental Agency for Innovation Systems (VINNOVA), and the Goran Gustafsson Foundation. M. M. also acknowledges "Subprograma Ramon y Cajal" for Contract RYC-2011-08972. The TEM used in this study was purchased from a grant by the Knut and Alice Wallenberg Foundation. ; Martínez Franco, R.; Moliner Marin, M.; Yun, Y.; Sun, J.; Wan, W.; Zou, X.; Corma Canós, A. (2013). Synthesis of an extra-large molecular sieve using proton sponges as organic structure-directing agents. Proceedings of the National Academy of Sciences. 110(10):3749-3754. https://doi.org/10.1073/pnas.1220733110 ; S ; 3749 ; 3754 ; 110 ; 10