Approaching business models from an economic perspective
In: Springer Briefs in Business
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In: Springer Briefs in Business
In: Journal of neurological surgery. Part A, Central European neurosurgery = Zentralblatt für Neurochirurgie
ISSN: 2193-6323
Background: Adamantinomatous craniopharyngioma (ACP) is the most common type of craniopharyngioma (CP). Under the current surgery and/or radiotherapy strategies, the survival rate is high but the long-term quality of life is poor because of the relationship between the hypothalamic-pituitary and the tumor. Many studies had shown that endocrine deficiencies caused by craniopharyngiomas of the hypothalamic-pituitary axis persist throughout almost the entire life of the patients after surgery, requiring them to receive hormone replacement therapy. Thus, we need to explore new treatments to improve the prognosis of patients. In recent years, there are more and more studies on immunotherapy of various tumors. However, due to the rarity of the disease, immunotherapy for ACP is rarely researched. The discovery of the tumor immunosuppressive checkpoint KLRB1 (Killer Cell Lectin Like Receptor B1), which encodes CD161, may provide a novel target for the treatment of ACP.
Methods: Data analysis of retrospective RNA-sequencing was conducted in a cohort of 51 pediatric samples in the GSE94349 dataset, and the results were well validated in the GSE68015 dataset including 31 pediatric samples. We used R language as the main tool for statistical analysis and graphical work.
Results: Our research showed that KLRB1 was enriched in ACP. Additionally, the expression of KLRB1 was positively related to immune functions and most inflammatory responses of ACP. We found that most of the T lineage–related immune responses were positively correlated with KLRB1 expression, and KLRB1 played an important role in the activation of inflammatory processes.
Conclusions: KLRB1 is a promising target for immunotherapeutic strategies.
In: Studies in educational evaluation, Band 78, S. 101264
ISSN: 0191-491X
SSRN
In: Feminist studies: FS, Band 47, Heft 2, S. 312-340
ISSN: 2153-3873
In: The American journal of sociology, Band 125, Heft 5, S. 1401-1403
ISSN: 1537-5390
In: Women's studies: an interdisciplinary journal, Band 42, Heft 5, S. 617-620
ISSN: 1547-7045
In: Innovation: organization & management: IOM, Band 15, Heft 1, S. 69-82
ISSN: 2204-0226
In: Women's studies: an interdisciplinary journal, Band 42, Heft 5, S. 617-620
ISSN: 0049-7878
In: Innovation: Management, policy & practice (2013) 15(1): 69–82.
SSRN
Working paper
In: Innovation: organization & management: IOM, S. 1509-1543
ISSN: 2204-0226
In: Innovation: organization & management: IOM, Band 14, Heft 3, S. 431-445
ISSN: 2204-0226
In: Innovation: organization & management: IOM, S. 2476-2511
ISSN: 2204-0226
"This is a book of China's own political narrative written by one of China's leading and best-known thinkers. It is the last part of the author's "China Trilogy", which is a best-seller in China, with over one million copies sold. The book in itself is a centerpiece of the unfolding debate within China on the nature and future of the country and how it compares with the West. It addresses a hugely important issue of the day, i.e., in what way China is overtaking or may overtake the United States as the world's preeminent power. The author provides an original and thought-provoking study on how China has managed, through its own development model, to catch up and even surpass, to various extents, the United States, in terms of gross GDP, net household assets and social protection. The book elaborates on how China has engaged itself in reshaping its institutions to ensure its smooth rise, drawing on the strengths of its own traditions, socialist legacies and elements from the West. It analyzes the weakness of the Western political institutions and discusses how China has developed its own institutional edge over the West. The author argues that as a civilizational state, China has evolved a logic of its own for development and its own political discourse which questions seriously many Western assumptions about democracy, good governance and universal values. The book recaptures the essence of China's past glory and discusses the horizon of the Chinese dream as well as how China should meet the various challenges ahead. It offers a unique and original perspective on the future of this coming superpower. Like The China Wave, this book is both discerning and provocative, and serves as a required reading for everyone concerned with the rise of China and its global implications."--