Suchergebnisse

Epithelial lineages have been studied at cellular resolution in multiple organs that turn over rapidly. However, many epithelia, including those of the lung, liver, pancreas, and prostate, turn over slowly and may be regulated differently. We investigated the mouse tracheal epithelial lineage at homeostasis by using long-term clonal analysis and mathematical modeling. This pseudostratified epithelium contains basal cells and secretory and multiciliated luminal cells. Our analysis revealed that basal cells are heterogeneous, comprising approximately equal numbers of multipotent stem cells and committed precursors, which persist in the basal layer for 11 days before differentiating to luminal fate. We confirmed the molecular and functional differences within the basal population by using single-cell qRT-PCR and further lineage labeling. Additionally, we show that self-renewal of short-lived secretory cells is a feature of homeostasis. We have thus revealed early luminal commitment of cells that are morphologically indistinguishable from stem cells. ; This study was supported by the Medical Research Council (G0900424 to E.R.), European Union grant EuroSyStem (200720; FP7/2008), the Newton Trust (to E.R.), the Wellcome Trust (098357/Z/12/Z to B.D.S.). Core grants from the Wellcome Trust (092096) and Cancer Research UK (C6946/A14492). ; This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.celrep.2015.06.011

Considering the features of GIs and organic production, Deliverable 5.2 analyses the relationships between Public Goods (PGs) and Food Quality Schemes (FQS). The deliverable evaluates the impacts of the cases study described in Deliverable 5.1 in terms of their contribution to rural development and territorial cohesion given by the capacity to generate positive externalities and hence PGs. The analysis focuses on: i) contribution to local economies; ii) generation of environmental, social and cultural externalities; iii) contribution of different governance mechanisms to ensure the valorisation of producers' know-how and local resources; iv) social cohesion in term of creation of social capital and social networks. Overall, the products that fall within the organic FQS category, contribute to the generation of environmental PGs more than the GI FQS. However, the latter contribute more to the generation of socio-economic PGs. In general, most FQS present a low capacity to generate Cultural Heritage PGs. This indicates that there is considerable space to improve the cultural dimension of these products for the benefit of producers and consumers. The analysis conducted by the Strength2Food methodology show that if there is political will on the part of producers, there is room for improvement in the generation of PGs. At the same time, the measurement of the capacity to produce PGs would further justify the greater economic value of these products to consumers.

Considering the features of GIs and organic production, Deliverable 5.2 analyses the relationships between Public Goods (PGs) and Food Quality Schemes (FQS). The deliverable evaluates the impacts of the cases study described in Deliverable 5.1 in terms of their contribution to rural development and territorial cohesion given by the capacity to generate positive externalities and hence PGs. The analysis focuses on: i) contribution to local economies; ii) generation of environmental, social and cultural externalities; iii) contribution of different governance mechanisms to ensure the valorisation of producers' know-how and local resources; iv) social cohesion in term of creation of social capital and social networks. Overall, the products that fall within the organic FQS category, contribute to the generation of environmental PGs more than the GI FQS. However, the latter contribute more to the generation of socio-economic PGs. In general, most FQS present a low capacity to generate Cultural Heritage PGs. This indicates that there is considerable space to improve the cultural dimension of these products for the benefit of producers and consumers. The analysis conducted by the Strength2Food methodology show that if there is political will on the part of producers, there is room for improvement in the generation of PGs. At the same time, the measurement of the capacity to produce PGs would further justify the greater economic value of these products to consumers.

Considering the features of GIs and organic production, Deliverable 5.2 analyses the relationships between Public Goods (PGs) and Food Quality Schemes (FQS). The deliverable evaluates the impacts of the cases study described in Deliverable 5.1 in terms of their contribution to rural development and territorial cohesion given by the capacity to generate positive externalities and hence PGs. The analysis focuses on: i) contribution to local economies; ii) generation of environmental, social and cultural externalities; iii) contribution of different governance mechanisms to ensure the valorisation of producers' know-how and local resources; iv) social cohesion in term of creation of social capital and social networks. Overall, the products that fall within the organic FQS category, contribute to the generation of environmental PGs more than the GI FQS. However, the latter contribute more to the generation of socio-economic PGs. In general, most FQS present a low capacity to generate Cultural Heritage PGs. This indicates that there is considerable space to improve the cultural dimension of these products for the benefit of producers and consumers. The analysis conducted by the Strength2Food methodology show that if there is political will on the part of producers, there is room for improvement in the generation of PGs. At the same time, the measurement of the capacity to produce PGs would further justify the greater economic value of these products to consumers.