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Article(print)#12006

Het vitale belang van de Rijnmond

In: Militaire spectator: MS ; maanblad ; waarin opgen. de officie͏̈le mededelingen van de Koninkl. Landmacht en de Koninkl. Luchtmacht, Volume 175, Issue 11, p. 520-527

Willems, R.

ISSN: 0026-3869

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Open Access#22014

Introduction: Aspiring migrants, local crises and the imagination of futures 'away from home'

In: Bal , E W & Willems , R 2014 , ' Introduction: Aspiring migrants, local crises and the imagination of futures 'away from home' ' , Identities: Global Studies in Culture and Power , vol. 21 , no. 3 , pp. 249-258 . https://doi.org/10.1080/1070289X.2014.858628 , https://doi.org/10.1080/1070289X.2013.833512

Bal, E.W; Willems, R

This special issue addresses the imagination of futures 'away from home' in a globalising world. While a growing number of migration scholars have taken into account that migration considerations are always socially embedded and culturally informed, the processes at work among a mounting number of (young) men and women throughout the world, who are convinced that a better life can only be found 'away from home', have been notably understudied. This special issue goes beyond the study of migration aspirations as a question of migration only. It focuses on the specific contexts (in five different countries) within which migration dreams are born, and sometimes even cultivated. It explores the sociocultural embedding of these aspirations by investigating the interpretation of local realities versus global possibilities, and examines how the aspirations of so many worldwide link up to the wider interconnections between globalisation and the sociocultural, political and economic transformations 'back home'. © 2013 Taylor & Francis.

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Open Access#32018

Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation

In: ESC Heart Failure

AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non-randomized control group). The primary endpoint is all-cause mortality; the co-primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost-effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12-lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. CONCLUSIONS: The EU-CERT-ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.

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Open Access#42019

Rationale and design of the EU‐CERT‐ICD prospective study:comparative effectiveness of prophylactic ICD implantation

Zabel, M. (Markus); Sticherling, C. (Christian); Willems, R. (Rik); Lubinski, A. (Andrzej); Bauer, A. (Axel); Bergau, L. (Leonard); Braunschweig, F. (Frieder); Brugada, J. (Josep)

Zabel, M. (Markus); Sticherling, C. (Christian); Willems, R. (Rik); Lubinski, A. (Andrzej); Bauer, A. (Axel); Bergau, L. (Leonard); Braunschweig, F. (Frieder); Brugada, J. (Josep); Brusich, S. (Sandro); Conen, D. (David); Cygankiewicz, I. (Iwona); Flevari, P. (Panagiota); Taborsky, M. (Milos); Hansen, J. (Jim); Hasenfuss, G. (Gerd); Hatala, R. (Robert); Huikuri, H. V. (Heikki V.); Iovev, S. (Svetoslav); Kaeaeb, S. (Stefan); Kaliska, G. (Gabriela); Kasprzak, J. D. (Jaroslaw D.); Luethje, L. (Lars); Malik, M. (Marek); Novotny, T. (Tomas); Pavlovic, N. (Nikola); Schmidt, G. (Georg); Shalganov, T. (Tchavdar); Sritharan, R. (Rajeeva); Schloegl, S. (Simon); Nossan, J. S. (Janko Szavits); Traykov, V. (Vassil); Tuinenburg, A. E. (Anton E.); Velchev, V. (Vasil); Vos, M. A. (Marc A.); Willich, S. N. (Stefan N.); Friede, T. (Tim); Svendsen, J. H. (Jesper Hastrup); Merkely, B. (Bela); Seegers, J. (J.); Munoz-Exposito, P. (P.); Tichelbacker, T. (T.); Kirovo, A. (A.); Sritharan, R. (R.); Joerss, K. (K.); Macken, J. (J.); Misdaq, M. (M.); Rudolph, K. (K.); Schmidt, G. (G.); Mueller, A. (A.); Dommasch, M. (M.); Sinnecker, D. (D.); Sinner, M. (M.); Bauer, A. (A.); Dissmann, R. (R.); Burmester, U. (U.); Behrens, S. (S.); Gregor, M. (M.); Stefanow, S. (S.); Rueb, N. (N.); Wolpert, C. (C.); Bimmel, D. (D.); Lieberz, C. (C.); Maier, L. (L.); Schwinger, R. (R.); Blaschke, F. (F.); Pieske, B. (B.); Groenefeld, G. (G.); Klein, G. (G.); Gardiwal, A. (A.); Merkely, B. (B.); Szeplaki, G. (G.); Perge, P. (P.); Nossan, J. S. (J. Szavits); Rotkvic, L. (L.); Pavlovic, N. (N.); Manola, S. (S.); Vinter, O. (O.); Benko, I. (I.); Brusic, S. (S.); Avdovic, E. (E.); Klasan, M. (M.); Bakotic, Z. (Z.); Anic, A. (A.); Lubinski, A. (A.); Kowalczyk, E. (E.); Kucejko, T. (T.); Czechowska, A. (A.); Wybor, K. (K.); Cygankiewicz, I. (I.); Ptaszynski, P. (P.); Kasprzak, J. (J.); Qavoq, H. (H.); Guzik, P. (P.); Krauze, T. (T.); Sterlinski, M. (M.); Hatala, R. (R.); Svetlosak, M. (M.); Kaliska, G. (G.); Martinek, J. (J.); Thamsborg, K. (K.); Hansen, J. (J.); Schloett-Hyldelund, I. M. (I. M.); Laage-Petersen, J. (J.); Willems, R. (R.); Vandenberk, B. (B.); van Soest, S. (S.); Traykov, V. (V.); Iovev, S. (S.); Shalganov, T. (T.); Sticherling, C. (C.); Conen, D. (D.); Giesebart, S. (S.); Novotny, T. (T.); Kozak, M. (M.); Taborsky, M. (M.); Galuszka, J. (J.); Tuinenburg, A. E. (A. E.); Wijers, S. (S.); Dunnink, A. (A.); Sprenkeler, D. (D.); Brugada, J. (J.); Arbelo, E. (E.); Trucco, E. (E.); Vidorreta, S. (S.); Huikuri, H. (H.); Kentta, T. (T.); Pelli, A. (A.); Huikuri, P. (P.); Koski, P. (P.); Braunschweig, F. (F.); Karlsson, H. (H.); Ersgaard, D. (D.); Platonov, P. (P.); Klingenheben, T. (T.); Scharfe, M. (M.); Reinhold, T. (T.); Cree, M. (M.); Hnatkova, K. (K.); Gerhardt, J. (J.); Rizas, K. (K.); Hamm, W. (W.); Roever, C. (C.); Harden, M. (M.); Kessel, B. (B.); Berg, A. (A.); Apel, S. (S.); Walker, F. (F.); Kirchhof, N. (N.); Goerlitz, A. (A.); Molitor, A. (A.); Heinrich, J. (J.); Annetzberger, S. (S.); Fuchs, B. (B.); Landwehr, A. (A.); Merk, A. (A.); Wilke, A. (A.); Hennecke, C. (C.); Mansch, R. (R.)

Abstract Aims: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims to assess its current clinical value. Methods and results: The EU‐CERT‐ICD is a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non‐randomized control group). The primary endpoint is all‐cause mortality; the co‐primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost‐effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12‐lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. Conclusions: The EU‐CERT‐ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.

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