Open Access#12019
Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase
The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2. ; We thank Jinan University, the Australian Research Council, and the Institute of Advanced Studies for financial support. H. S. K. and G. J. C. are the grateful recipients of scholarships provided by the Australian Government.