Usage behavior at roadside station restaurants and users' evaluation of regional revitalization
In: Journal of the City Planning Institute of Japan, Band 56, Heft 3, S. 1129-1136
ISSN: 2185-0593
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In: Journal of the City Planning Institute of Japan, Band 56, Heft 3, S. 1129-1136
ISSN: 2185-0593
In: Journal of the City Planning Institute of Japan, Band 55, Heft 3, S. 1092-1099
ISSN: 2185-0593
In: Journal of the City Planning Institute of Japan, Band 53, Heft 3, S. 1215-1222
ISSN: 2185-0593
In: Journal of behavioral and experimental economics, Band 98, S. 101853
ISSN: 2214-8043
In: Journal of the City Planning Institute of Japan, Band 50, Heft 3, S. 1316-1323
ISSN: 2185-0593
In: Journal of the City Planning Institute of Japan, Band 19, Heft 0, S. 43-48
ISSN: 2185-0593
In: Dynamic games and applications: DGA, Band 13, Heft 2, S. 589-609
ISSN: 2153-0793
SSRN
In: Journal of the City Planning Institute of Japan, Band 49, Heft 3, S. 549-554
ISSN: 2185-0593
In: Journal of the City Planning Institute of Japan, Band 49, Heft 3, S. 903-908
ISSN: 2185-0593
In: Journal of the City Planning Institute of Japan, Band 51, Heft 3, S. 966-971
ISSN: 2185-0593
In: Twin research and human genetics: the official journal of the International Society for Twin Studies (ISTS) and the Human Genetics Society of Australasia, Band 15, Heft 4, S. 522-526
ISSN: 1839-2628
This study was conducted to review the overall short-term outcome of monoamniotic twins in Japan and to determine the prospective risk of fetal death so as to adequately counsel parents with monoamniotic twins. Study subjects were 101 women with monoamniotic twins who were registered with the Japan Society of Obstetrics and Gynecology Successive Pregnancy Birth Registry System and who had given birth at ≥22 weeks of gestation during 2002–2009. The gestational week at delivery (mean ± SD) was 31.8 ± 3.7. Fourteen women experienced intrauterine fetal death (IUFD). Short-term outcomes of co-twins born to the 14 women included 8 IUFDs, one early neonatal death within 7 days of life (END), and 5 survivors. Four other women experienced 5 ENDs. Thus, 13.9% (28/202) of infants died perinatally (22 IUFDs and 6 ENDs), 13.9% (14/101) of women experienced IUFD, and 82.2% (83/101) of women experienced neither IUFD nor END. Structural anomalies and twin-to-twin transfusion syndrome explained 17.9% (five infants) and 10.7% (three infants) of the 28 perinatal deaths, respectively. The prospective risk of IUFD was 13.9% (14/101) for women who reached gestational week 22−0/7, gradually decreasing thereafter but remaining at between 4.5% and 8.0% between gestational week 30−0/7 and 36−0/7.
The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regulatory representatives from key organizations including European regulatory agencies, such as the European Chemicals Agency (ECHA) and the European Food Safety Authority (EFSA), as well as the Scientific Committee on Consumer Safety (SCCS), national agencies from several European countries, Japan, Canada and the USA, as well as the Organisation for Economic Cooperation and Development (OECD). More than a hundred people actively participated in the discussions, bringing together diverse viewpoints across academia, regulators and industry. The discussion was organized starting from five practical cases of RAx applied to specific problems that offered the oppor-tunity to consider real examples. There was general consensus that NAMs can improve confidence in RAx, in particular in defining category boundaries as well as characterizing the similarities/dissimilarities between source and target substances. In addition to describing dynamics, NAMs can be helpful in terms of kinetics and metabolism that may play an important role in the demonstration of similarity or dissimilarity among the members of a category. NAMs were also noted as effective in providing quanti-tative data correlated with traditional no observed adverse effect levels (NOAELs) used in risk assessment, while reducing the uncertainty on the final conclusion. An interesting point of view was the advice on calibrating the number of new tests that should be carefully selected, avoiding the allure of "the more, the better". Unfortunately, yet unsurprisingly, there was no single approach befitting every case, requiring careful analysis delineating the optimal approach. Expert analysis and assessment of each specific case is still an important step in the process.
BASE
In: Rovida , C , Escher , S E , Herzler , M , Bennekou , S H , Kamp , H , Kroese , D E , Maslankiewicz , L , Moné , M J , Patlewicz , G , Sipes , N , Van Aerts , L , White , A , Yamada , T & Van de Water , B 2021 , ' NAM-supported read-across : From case studies to regulatory guidance in safety assessment ' , A L T E X. Alternatives to Animal Experimentation , vol. 38 , no. 1 , pp. 140-150 . https://doi.org/10.14573/altex.2010062
The use of new approach methodologies (NAMs) in support of read-across (RAx) approaches for regulatory purposes is a main goal of the EU-ToxRisk project. To bring this forward, EU-ToxRisk partners convened a workshop in close collaboration with regulatory representatives from key organizations including European regulatory agencies, such as the European Chemicals Agency (ECHA) and the European Food Safety Authority (EFSA), as well as the Scientific Committee on Consumer Safety (SCCS), national agencies from several European countries, Japan, Canada and the USA, as well as the Organisation for Economic Cooperation and Development (OECD). More than a hundred people actively participated in the discussions, bringing together diverse viewpoints across academia, regulators and industry. The discussion was organized starting from five practical cases of RAx applied to specific problems that offered the oppor-tunity to consider real examples. There was general consensus that NAMs can improve confidence in RAx, in particular in defining category boundaries as well as characterizing the similarities/dissimilarities between source and target substances. In addition to describing dynamics, NAMs can be helpful in terms of kinetics and metabolism that may play an important role in the demonstration of similarity or dissimilarity among the members of a category. NAMs were also noted as effective in providing quanti-tative data correlated with traditional no observed adverse effect levels (NOAELs) used in risk assessment, while reducing the uncertainty on the final conclusion. An interesting point of view was the advice on calibrating the number of new tests that should be carefully selected, avoiding the allure of "the more, the better". Unfortunately, yet unsurprisingly, there was no single approach befitting every case, requiring careful analysis delineating the optimal approach. Expert analysis and assessment of each specific case is still an important step in the process.
BASE