Metamorphic P-T trajectory and multi-stage fluid events of vein-bearing UHP eclogites from the Dabie terrane: insights from compositional zonations of key minerals
In: International Geology Review, Band 57, Heft 9-10, S. 1077-1102
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In: International Geology Review, Band 57, Heft 9-10, S. 1077-1102
In: International Geology Review, Band 55, Heft 10, S. 1239-1260
In: International Geology Review, Band 55, Heft 12, S. 1506-1522
In: Progress in nuclear energy: the international review journal covering all aspects of nuclear energy, Band 113, S. 74-83
ISSN: 0149-1970
In: Science and technology of nuclear installations, Band 2016, S. 1-10
ISSN: 1687-6083
Helically coiled tube Once-Through Steam Generator (H-OTSG) is one of the key equipment types for small modular reactors. The flow instability of the secondary side of the H-OTSG is particularly serious, because the working condition is in the range of low and medium pressure. This paper presents research on density wave oscillations (DWO) in a typical countercurrent H-OTSG. Based on the steady-state calculation, the mathematical model of single-channel system was established, and the transfer function was derived. Using Nyquist stability criterion of the single variable, the stability cases were studied with an in-house computer program. According to the analyses, the impact law of the geometrical parameters to the system stability was obtained. RELAP5/MOD3.2 code was also used to simulate DWO in H-OTSG. The theoretical analyses of the in-house program were compared to the simulation results of RELAP5. A correction factor was introduced to reduce the error of RELAP5 when modeling helical geometry. The comparison results agreed well which showed that the correction is effective.
In: Environmental science and pollution research: ESPR, Band 26, Heft 27, S. 28216-28227
ISSN: 1614-7499
In: Environmental science and pollution research: ESPR, Band 26, Heft 1, S. 784-796
ISSN: 1614-7499
In: Twin research and human genetics: the official journal of the International Society for Twin Studies (ISTS) and the Human Genetics Society of Australasia, Band 16, Heft 6, S. 1026-1032
ISSN: 1839-2628
It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erroneous proteins to cause an error catastrophe hampered any firm conclusions on these theories. In this study, we sequenced the whole genome of DNA in whole blood of two pairs of monozygotic (MZ) twins, 40 and 100 years old, by two independent next-generation sequencing (NGS) platforms (Illumina and Complete Genomics). Potentially discordant single-base substitutions supported by both platforms were validated extensively by Sanger, Roche 454, and Ion Torrent sequencing. We demonstrate that the genomes of the two twin pairs are germ-line identical between co-twins, and that the genomes of the 100-year-old MZ twins are discerned by eight confirmed somatic single-base substitutions, five of which are within introns. Putative somatic variation between the 40-year-old twins was not confirmed in the validation phase. We conclude from this systematic effort that by using two independent NGS platforms, somatic single nucleotide substitutions can be detected, and that a century of life did not result in a large number of detectable somatic mutations in blood. The low number of somatic variants observed by using two NGS platforms might provide a framework for detecting disease-related somatic variants in phenotypically discordant MZ twins.