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Tissue-Level Signaling and Control of Uterine Contractility: The Action Potential—Calcium Wave Hypothesis
In: Journal of the Society for Gynecologic Investigation: official publication of the Society for Gynecologic Investigation, Band 7, Heft 3, S. 146-152
ISSN: 1556-7117
Canadian Food Aid: Surpluses and Hunger
In: International journal / Canadian Institute of International Affairs, Band 36, Heft 2, S. 335-352
ISSN: 2052-465X
Zambia: Adjusting to poverty
The purpose of this report is to provide an analysis of recent macroeconomic trends in Zambia and the coherence and impact of attempts at economic policy reform. The paper focuses on the period 1980-87 with special attention being paid to the most recent effort to adjust to declining fortunes from October 1985 until May 1987 when Zambia abandoned the stewardship of IBRD and IMF structural adjustment programs and chose to seek an accomodation to economic decline by undertaking to meet its economic development objectives from its own resources
World Affairs Online
Mechanotransduction in Rat Myometrium: Coordination of Contractions of Electrically and Chemically Isolated Tissues
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 18, Heft 1, S. 64-69
ISSN: 1933-7205
Calcium-Activated Chloride Currents Prolongs the Duration of Contractions in Pregnant Rat Myometrial Tissue
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 16, Heft 8, S. 734-739
ISSN: 1933-7205
Tissue-Level Bioelectrical Signals as the Trigger for Uterine Contractions in Human Pregnancy
In: Journal of the Society for Gynecologic Investigation: official publication of the Society for Gynecologic Investigation, Band 11, Heft 7, S. 478-482
ISSN: 1556-7117
Maintaining Squamous Epithelial Architecture in a Human Cervical Epithelium to SCID Mouse Xenograft Model System
In: Journal of the Society for Gynecologic Investigation: official publication of the Society for Gynecologic Investigation, Band 6, Heft 4, S. 208-212
ISSN: 1556-7117
Canadian Development Assistance to Bangladesh
In: Canadian public policy: Analyse de politiques, Band 10, Heft 4, S. 488
ISSN: 1911-9917
Taking Stock: World Food Security in the Eighties
In: Canadian public policy: Analyse de politiques, Band 8, Heft 1, S. 130
ISSN: 1911-9917
Technology and the Third World: The Issues and the Role for Canada
In: Canadian public policy: Analyse de politiques, Band 6, Heft 2, S. 423
ISSN: 1911-9917
Nifedipine Block of Capacitative Calcium Entry in Cultured Human Uterine Smooth-Muscle Cells
In: Journal of the Society for Gynecologic Investigation: official publication of the Society for Gynecologic Investigation, Band 8, Heft 4, S. 210-215
ISSN: 1556-7117
A missing piece of the puzzle of on-farm freshwater restoration: What motivates land managers to record and report land management actions?
In: Ecology and society: E&S ; a journal of integrative science for resilience and sustainability, Band 27, Heft 4
ISSN: 1708-3087
Directional Sensors for Recording Uterine EMG During Pregnancy
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 30, Heft 11, S. 3190-3196
ISSN: 1933-7205
Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 30, Heft 1, S. 203-220
ISSN: 1933-7205
Abstract
The intracellular signaling pathways that regulate myometrial contractions can be targeted by drugs for tocolysis. The agents, 2-APB, glycyl-H-1152, and HC-067047, have been identified as inhibitors of uterine contractility and may have tocolytic potential. However, the contraction-blocking potency of these novel tocolytics was yet to be comprehensively assessed and compared to agents that have seen greater scrutiny, such as the phosphodiesterase inhibitors, aminophylline and rolipram, or the clinically used tocolytics, nifedipine and indomethacin. We determined the IC50 concentrations (inhibit 50% of baseline contractility) for 2-APB, glycyl-H-1152, HC-067047, aminophylline, rolipram, nifedipine, and indomethacin against spontaneous ex vivo contractions in pregnant human myometrium, and then compared their tocolytic potency. Myometrial strips obtained from term, not-in-labor women, were treated with cumulative concentrations of the contraction-blocking agents. Comprehensive dose–response curves were generated. The IC50 concentrations were 53 µM for 2-APB, 18.2 µM for glycyl-H-1152, 48 µM for HC-067047, 318.5 µM for aminophylline, 4.3 µM for rolipram, 10 nM for nifedipine, and 59.5 µM for indomethacin. A single treatment with each drug at the determined IC50 concentration was confirmed to reduce contraction performance (AUC) by approximately 50%. Of the three novel tocolytics examined, glycyl-H-1152 was the most potent inhibitor. However, of all the drugs examined, the overall order of contraction-blocking potency in decreasing order was nifedipine > rolipram > glycyl-H-1152 > HC-067047 > 2-APB > indomethacin > aminophylline. These data provide greater insight into the contraction-blocking properties of some novel tocolytics, with glycyl-H-1152, in particular, emerging as a potential novel tocolytic for preventing preterm birth.