Suchergebnisse

This article appeared in Homeland Security Affairs (March 2011), Supplement no.3 ; The protection of perimeters in national, agricultural, airport, prison, and military sites, and residential areas against dangerous approaching human and vehicles when using human agents to provide security is expensive or unsafe. Because of this, acoustic/vibration signature identification of approaching human and vehicles threats has attracted increased attention. This paper addresses the development and deployment of three types of acoustic and vibration based smart sensors to identify and report sequential approaching threats prior to the intrusion. More specifically, we have developed: a) acoustic based long range sensor with which vehicles' engine sound and type can be identified, b) vibration based seismic analyzer which discriminates between human footsteps and other seismic events such as those caused by animals, and c) fence breaching vibration sensor which can detect intentional disturbances on the fence and discriminate between climb, kick, rattle, and lean. All of these sensors were designed with several issues in mind, namely, optimized low power usage, a low number of false positives, small size, secure radio communication, and military specifications. The developed vibration based system was installed in an airport with unprotected shore lines in the vicinity of taxi-and run-ways. The system reported an average of less than two false positives per week and zero false negative for the duration of forty-five days. Six fence sensors were installed on the terminal area and end-of runway chain-link fences where there was possibility of intentional fence climbing. The fence sensors reported no false positives for the duration of forty-five days which included several days of seasonal storms. ; Approved for public release; distribution is unlimited.

Neurochemical changes evoked by electrical stimulation of the nervous system have been linked to both therapeutic and undesired effects of neuromodulation therapies used to treat obsessive-compulsive disorder, depression, epilepsy, Parkinson's disease, stroke, hypertension, tinnitus, and many other indications. In fact, interest in better understanding the role of neurochemical signaling in neuromodulation therapies has been a focus of recent government- and industry-sponsored programs whose ultimate goal is to usher in an era of personalized medicine by creating neuromodulation therapies that respond to real-time changes in patient status. A key element to achieving these precision therapeutic interventions is the development of mathematical modeling approaches capable of describing the nonlinear transfer function between neuromodulation parameters and evoked neurochemical changes. Here, we propose two computational modeling frameworks, based on artificial neural networks (ANNs) and Volterra kernels, that can characterize the input/output transfer functions of stimulation-evoked neurochemical release. We evaluate the ability of these modeling frameworks to characterize subject-specific neurochemical kinetics by accurately describing stimulation-evoked dopamine release across rodent (R2 = 0.83 Volterra kernel, R2 = 0.86 ANN), swine (R2 = 0.90 Volterra kernel, R2 = 0.93 ANN), and non-human primate (R2 = 0.98 Volterra kernel, R2 = 0.96 ANN) models of brain stimulation. Ultimately, these models will not only improve understanding of neurochemical signaling in healthy and diseased brains but also facilitate the development of neuromodulation strategies capable of controlling neurochemical release via closed-loop strategies.