Direct transformation of i-steroid methyl ethers in 6-ketones: the use in the synthesis of brassinosteroids
In: Proceedings of the National Academy of Sciences of Belarus, Chemical Series, Band 55, Heft 2, S. 175-181
ISSN: 2524-2342
A one-step method for the transformation of 3α,5-cyclo-6β-methyl ethers of steroids into the corresponding 3α,5-cyclo-6-ketones under the action of methyl (trifluoromethyl) dioxirane has been developed. The possibilities of the method have been demonstrated by preparing 3-dehydrotesterone, the biosynthetic precursor of brassinolide.