Suchergebnisse

Our study focused on the low leader–member exchange (LMX) minority under the LMX differentiation context. Specifically, based on the group engagement model, we proposed that high LMX relational separation (LMXRS) impairs subordinates' organizational altruism behaviors through undermining their procedural justice perception; furthermore, such an effect is stronger for low-LMX members in low overall LMX differentiation groups. Using data collected from 4 companies in China that included 49 teams and 273 employees, we demonstrated that high LMXRS entails a lower procedural justice perception and fewer follow-up altruism behaviors, especially for low-LMX members. Moreover, the three-way interaction result showed that the detrimental effect of high LMXRS on low-LMX members' procedural justice perception and follow-up organizational altruism behaviors is stronger when the group-level LMX differentiation is low. We discussed the theoretical and practical implications of these findings.

Abstract
Tubulin beta 8 class VIII (TUBB8) is a β-tubulin isotype that is specifically expressed in human oocytes and early embryos. It has been identified as a disease-causing gene in primary female infertility by affecting oocyte maturation arrest. This study investigated the genetic cause of female infertility in five patients from four families. Five women with primary infertility were recruited. Medical-exome sequencing and Sanger sequencing were performed on the patients, and their family members to identify candidate genes that explained infertility. Additionally, the morphology of oocytes and zygotes from the patients and controls were assessed. We observed recurrent oocytes MI arrest, oocytes abnormal fertilization, uncleaved embryos, and embryo transfer failure in the patients. Heterozygous missense variants in TUBB8, c.538G > A (p.V180M), c.527C > G (p.S176W), c.124C > G (p.L42V), and c.628A > C (p.I210L), were verified in four unrelated families. This study expanded the mutational spectrum of TUBB8 by identifying three novel heterozygous missense variants. Screening for TUBB8 mutation demonstrated the diagnostic utility of female infertility.