Suchergebnisse

SIMPLE SUMMARY: Over the years, rumen acidosis is considered as the most common disease in ruminants, which affects animal health and brings huge economic losses of the ruminant industry. Antibiotic have been considered as effective to alleviate the occurrence of ruminal acidosis. However, antibiotic usage in food animals has been absolutely banned by European Union and strictly restricted in other countries. It is necessary to search for safe, effective and healthy additives alternative to antibiotics for ruminants. β-sitosterol is a plant compound known as phytosterol, which has many biological activities. In this study, sheep were feed four levels with β-sitosterol supplementation (0, 0.25, 0.5, and 1.0 g/kg). We concluded that β-sitosterol could attenuate high grain diet-induced inflammatory response and modify ruminal fermentation. These findings provide updated insight for preventing the occurrence of rumen acidosis. ABSTRACT: β-sitosterol (BSS) is a plant-derived natural bioactive compound, its cellular mechanism of anti-inflammatory activity has been proven recently. Little information is available regarding the application of BSS on ruminants under high grain diet. The objective of this study was to evaluate the effects of dietary BSS supplementation on inflammatory response, ruminal fermentation characteristics and the composition of the ruminal bacterial community under high grain diet. Eight rumen-cannulated Hu sheep (59.7 ± 4.8 kg of initial body weight) were randomly assigned into a replicated 4 × 4 Latin square design trial. Sheep were fed a high grain diet (non-fiber carbohydrate: neutral detergent fiber = 2.03) supplemented either with 0.25 (LBS), 0.5 (MBS), 1.0 (HBS) or without (CON) g BSS /kg dry matter diet. On day 21 of each period, rumen content samples were obtained at 6 h postfeeding, and blood samples were obtained before morning feeding. The data showed that compared with control group, Dietary BSS supplementation decreased serum concentrations of tumor necrosis factor, interleukin ...