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At present the land subsidence has been the main geological disaster in the plain area of China, and became one of the most serious disaster that restrict the social and economic sustainable development, it also is an important content in the project of national geographic conditions monitoring. With the development of economy and society, Beijing as the capital of China has experienced significant population growth in the last few decades which led to over-exploitation of the ground water to meet the water demand of more than 20 million inhabitants, especially in the urban region with high population density. However, the rainfall and surface runoff can't satisfy the need of aquifer recharge that product the land subsidence. As China's political center and a metropolis, there are a lot of large constructions, underground traffic projects and complicated municipal pipeline network, and Beijing is also an important traffic hub for national railway and highway network, all of them would be threatened by the land subsidence disaster. In this article the author used twenty ENVISAT Synthetic Aperture Radar (SAR) images acquired in 2008 June–2010 August and ten TerraSAR images acquired in 2011 June–2012 September were processed with Small Baseline Subset SAR Interferometry (SBAS-InSAR) techniques, to investigate spatial and temporal patterns of land subsidence in the urban area of Beijing.

At present the land subsidence has been the main geological disaster in the plain area of China, and became one of the most serious disaster that restrict the social and economic sustainable development, it also is an important content in the project of national geographic conditions monitoring. With the development of economy and society, Beijing as the capital of China has experienced significant population growth in the last few decades which led to over-exploitation of the ground water to meet the water demand of more than 20 million inhabitants, especially in the urban region with high population density. However, the rainfall and surface runoff can't satisfy the need of aquifer recharge that product the land subsidence. As China's political center and a metropolis, there are a lot of large constructions, underground traffic projects and complicated municipal pipeline network, and Beijing is also an important traffic hub for national railway and highway network, all of them would be threatened by the land subsidence disaster. In this article the author used twenty ENVISAT Synthetic Aperture Radar (SAR) images acquired in 2008 June–2010 August and ten TerraSAR images acquired in 2011 June–2012 September were processed with Small Baseline Subset SAR Interferometry (SBAS-InSAR) techniques, to investigate spatial and temporal patterns of land subsidence in the urban area of Beijing.

Abstract. Southwest China is located in the southeastern margin of the Tibetan Plateau and it is a region of high seismic activity. Historically, strong earthquakes that occurred here usually generated lots of landslides and brought destructive damages. This paper introduces several earthquake-triggered landslide events in this region and describes their characteristics. Also, the historical data of earthquakes with a magnitude of 7.0 or greater, having occurred in this region, is collected and the relationship between the affected area of landslides and earthquake magnitude is analysed. Based on the study, it can be concluded that strong earthquakes, steep topography as well as fragile geological environment, are the main reasons responsible for serious landslides in southwest China. At the same time, it is found that the relationship between the area affected by landslides and the earthquake magnitude in this region are consistent with what has been obtained worldwide. Moreover, in this paper, it is seen that the size of the areas affected by landslides change enormously even under the same earthquake magnitude in the study region. While at the same tectonic place or fault belt, areas affected by landslides presented similar outline and size. This means that local geological conditions and historical earthquake background have an important influence on landslides distribution, and they should be considered when assessing earthquake-triggered landslide hazards at Grade 1 according to ISSMGE.

Localized flux, production and/or degradation coupled to limited diffusion are well-known to result in stable spatial concentration gradients of biomolecules in the cell. In this study, we demonstrate that this also holds true for small ions, since we found that the close membrane apposition between the membrane of a phagosome and the surface of the cargo particle it encloses, suffices for stable gradients of protons and iron cations within the lumen of the phagosome. Our data show that in phagosomes containing hexapod-shaped silica colloid particles, the phagosomal membrane is ruptured at the positions of the tips of the rods, but not at other positions. This results in the confined leakage at these positions of protons and iron from the lumen of the phagosome into the cytosol. In contrast, acidification and iron accumulation still occur at the positions of the phagosomes of the cores of the particles. Our study strengthens the concept that the coupling of metabolic and signaling reaction cascades can be spatially confined by localized limited diffusion. ; ST, SS and GB are funded by a Young Investigator Grant from the Human Frontier Science Program (HFSP; RGY0080/2018). GB has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 862137) and the Netherlands Organization for Scientific Research (Vidi grant NWO-ALW VIDI 864.14.001). ST further acknowledges support from the Department of Atomic Energy, Government of India, under project no. 12-R&D-TFR-5.04-0800 and 12-D&D-TFR-5.10-1100, the Simons Foundation (Grant No. 287975) and the Max Planck Society through a Max-Planck Partner-Group.

The Xuanwei area of Yunnan Province, China, is one of the regions suffering from the highest occurrence and mortality rate of lung cancer in the world. Local residents tend to use bituminous coal as domestic fuel, which causes serious indoor air pollution and is established as the main carcinogen. After the local government carried out furnace and stove reform work, lung cancer rate including incidence and mortality among residents remains high. We herein wonder if there are specific mechanisms at protein level for the development of non‐small‐cell lung cancer (NSCLC) in this area. We investigated the changes of protein profiling in tumour of the patients from Xuanwei area. Tandem mass tag (TMT) was employed to screen the differential proteins between carcinoma and para‐carcinoma tissues. We identified a total of 422 differentially expressed proteins, among which 162 proteins were significantly up‐regulated and 260 were downregulated compared to para‐carcinoma tissues. Many of the differentially expressed proteins were related to extracellular matrix (ECM)‐receptor interaction, focal adhesion, PI3K/AKT pathway and ferroptosis. Further experiments on the two differential proteins, thioredoxin 2 (TXN2) and haptoglobin (HP), showed that the change of their expressions could make the lung cancer cell lines more resistant to erastin or RSL‐induced ferroptosis in vitro, and promote the growth of tumour in nude mice. In conclusion, this study revealed that aberrant regulation of ferroptosis may involve in the development of lung cancer in Xuanwei area.

Marine ecosystems around the globe are increasingly affected by human activities such as fisheries, shipping, offshore petroleum developments, wind farms, recreation, tourism and more. Whereas the necessity and urgency to regulate and plan competing marine spatial claims is growing, the planning and regulation of these claims is even more difficult than on land, among others because of insufficient data and knowledge on how ecosystems are affected, the international dimension of marine ecosystems and, as yet, poorly validated Marine Spatial Planning practices. The main question in this paper is: what exactly defines the high level of complexity of Marine Spatial Planning (MSP), and, given the strong transnational dimension of MSP, what can be done to integrate and harmonize the various planning practices of the EU member states? In this paper, the authors present the use of an international simulation-game (with 68 international MSP professionals in Lisbon, 3 November 2011) to conduct an expert panel study on MSP, both in the real and gamed countries. In order to analyze the panel and in-game data, several scales on MSP-outcome and process were defined and validated. In this paper the authors present the main insights of the pre-game panel study. They conclude that the differences in approaches to the MSP process and outcomes among the real countries are significant. ; Multi Actor Systems ; Technology, Policy and Management

###EgeUn### ; The Sariçiçek howardite meteorite shower consisting of 343 documented stones occurred on September 2, 2015 in Turkey and is the first documented howardite fall. Cosmogenic isotopes show that Sariçiçek experienced a complex cosmic-ray exposure history, exposed during ~12–14 Ma in a regolith near the surface of a parent asteroid, and that an ~1 m sized meteoroid was launched by an impact 22 ± 2 Ma ago to Earth (as did one-third of all HED meteorites). SIMS dating of zircon and baddeleyite yielded 4550.4 ± 2.5 Ma and 4553 ± 8.8 Ma crystallization ages for the basaltic magma clasts. The apatite U-Pb age of 4525 ± 17 Ma, K-Ar age of ~3.9 Ga, and the U,Th-He ages of 1.8 ± 0.7 and 2.6 ± 0.3 Ga are interpreted to represent thermal metamorphic and impact-related resetting ages, respectively. Petrographic; geochemical; and O-, Cr-, and Ti-isotopic studies confirm that Sariçiçek belongs to the normal clan of HED meteorites. Petrographic observations and analysis of organic material indicate a small portion of carbonaceous chondrite material in the Sariçiçek regolith and organic contamination of the meteorite after a few days on soil. Video observations of the fall show an atmospheric entry at 17.3 ± 0.8 km s -1 from NW; fragmentations at 37, 33, 31, and 27 km altitude; and provide a pre-atmospheric orbit that is the first dynamical link between the normal HED meteorite clan and the inner Main Belt. Spectral data indicate the similarity of Sariçiçek with the Vesta asteroid family (V-class) spectra, a group of asteroids stretching to delivery resonances, which includes (4) Vesta. Dynamical modeling of meteoroid delivery to Earth shows that the complete disruption of a ~1 km sized Vesta family asteroid or a ~10 km sized impact crater on Vesta is required to provide sufficient meteoroids ?4 m in size to account for the influx of meteorites from this HED clan. The 16.7 km diameter Antionia impact crater on Vesta was formed on terrain of the same age as given by the 4 He retention age of Sariçiçek. Lunar scaling for crater production to crater counts of its ejecta blanket show it was formed ~22 Ma ago. © The Meteoritical Society, 2019. ; 58261, 40339 nccr – on the move NNX14AM62G MFAG/113F035 Simons Foundation: 302497 NNX14-AR92G, NNX16AD34G Academy of Finland: 299543 Government Council on Grants, Russian Federation: ? 02., A03.21.0006 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung: PZ00P2_154874 Ministry of Education and Science of the Russian Federation: 3.1959.2017/4.6 National Natural Science Foundation of China: 41403055 ; Acknowledgments—We thank N. Ergu€n and family in the village of Sari©ci©cek for donating the meteorites studied here and collecting meteorite fall coordinates. We thank E. Atalan and S. Ozdemir€ at Bingo€l University, and E. Necip Yardım and M. C© i©cek at Mu©s Alparslan University, for facilitating our research at the campuses, and S. Pamuk at the Bingo€l police headquarters. We thank A. and T. Ozdum€ an, police officers in Bingo€l, for assisting with the field study. For technical assistance, we further acknowledge support from M. Fehr, Y.-J. Lai, and L. Hoffland (NASA Ames Research Center); David Mittlefehldt (NASA JSC); K. Wimmer (Ries Crater Museum); J. Sanchez (Planetary Science Institute); A. Neesemann (Free University Berlin); S. Atanasova-Vladimirova and I. Piroeva (Institute of Physical Chemistry, BAS); and B. Georgieva and V. Strijkova (Institute of Optical Materials and Technologies, BAS). This work was supported by Istanbul University (Project No. 40339 and 58261), the Scientific and Technological Research Council of Turkey (MFAG/113F035), the Swiss National Science foundation (PZ00P2_154874 and NCCR PlanetS), the Ministry of Science and Higher Education of the Russian Federation (Project # 3.1959.2017/4.6), Act 211 of the Government of the Russian Federation, contract ? 02.A03.21.0006, the National Natural Science Foundation of China (41403055), the Simons Foundation (302497), the Academy of Finland (299543), the NASA Cosmochemistry Program (NNX14AM62G), the NASA Emerging Worlds Program (NNX16AD34G), and the NASA NEOO program (NNX14-AR92G). --