Suchergebnisse

Abstract
Chemical risk assessment typically focusses on individual substances. However, people are exposed daily to multiple chemicals from diverse sources. The Monte Carlo Risk Assessment (MCRA) platform, developed by Wageningen University & Research (WUR, Biometris) for the Dutch Institute for Public Health and the Environment (RIVM), addresses this issue by enabling cumulative risk assessment (CRA). Recognising the need for mixture risk assessment (MRA), the European Food Safety Authority (EFSA) and RIVM collaborated under a Framework Partnership Agreement (FPA) to enhance the MCRA software for user‐friendly and transparent MRA. These enhancements include the development of a new standard regulatory action (SRA) and the refinement of existing retrospective SRAs. The new prospective SRA enables the evaluation of scenarios for new (proposed) maximum residue levels (MRL) for substances within existing cumulative assessment groups (CAG), with the potential for future application to new substances. Regarding the updates of existing retrospective SRAs, more recent occurrence data, food consumption data from more countries compared to the previous version of the SRA, and additional health effects/CAGs were included. Future actions may include further development and periodic updates of the current retrospective SRAs in MCRA, incorporating new considerations and data. These improvements facilitate compliance with regulatory methods and support efficient risk assessment.

Abstract
Current risk assessment practices for chemicals primarily focus on individual substances or predefined mixtures. However, people are exposed daily to multiple chemicals from diverse sources. The Monte Carlo Risk Assessment (MCRA) platform, an open web‐based tool, facilitates cumulative risk assessment (CRA) of chemicals. It is developed by Wageningen University & Research (WUR, Biometris) for the Dutch Institute for Public Health and the Environment (RIVM). The a (EFSA) and RIVM have initiated a Framework Partnership Agreement (FPA) to enhance mixture risk assessment (MRA) capabilities in MCRA. This report describes the collaborative efforts of EFSA and RIVM to make the MCRA platform more interoperable and accessible, focusing on data connectivity and security. Emphasis is placed on integrating relevant data used in Standard Regulatory Actions (SRA) implemented in MCRA, ensuring up‐to‐date and relevant information. RIVM's security measures, including a security quick‐scan and subsequent risk management plan, ensure a secure information and communications technology (ICT) and data hosting environment, especially for privacy sensitive data (e.g., food consumption data). A workflow for data exchange from EFSA to MCRA is proposed, focusing on standardisation and automation to minimise manual operations. This workflow builds on EFSA's established yearly pesticide data collection and reporting cycle. Additionally, efforts to align MCRA with other modelling software are explored. Ensuring Open MCRA's accessibility, various user groups are defined, enhancing the platform's usability for diverse stakeholders.