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SummarySome aspects of the spread observed in time studies.In the introduction the importance of time studies in mass production is mentioned. Next figures 1, 2 and 3 give some examples of the frequency distributions observed for the time intervals required for cyclical factory operations. It is pointed out that for comparing different jobs the specific deviation, s/√t, is often more useful than the standard deviation, s, or the average time t̄. If greater detail is required a study of the historic sequency may be of advantage; this sometimes reveals marked periodicity in speed (fig. 5). If one cyclical operation is split up in a number of phases, the variance of the whole is often larger than the sum of the variances of th; components, wich demonstrates the existence of correlations. Sometimes the distribution of 1/t or of 1/t2 is found to be slcser to normal than that oft. In ajinal section the main causes of variation are briefly surveyed.

It is often said that children have always been working. With the onset of the industrial revolution in the nineteenth century, however, children became to be exploited under miserable circumstances in factories. That was the beginning of the movement against child labour. A worldwide awareness campaign has brought international organizations and governments to the position that child labour should urgently be replaced by child education. The objectives seem simple and laudable but the issues involved are very complex. What actually is child labour, and what is childhood? How many child labourers are there in the world? Is child labour restricted to developing countries or is it frequently used in order to stigmatize the non-Western world? Is regulation of labour conditions the solution or should governments and civil society one opt for a radical ban? Is there a role for corporate social responsibility? These questions have been addressed in the professorial address on Child Labour Studies. It is argued that much more research is needed and that particular care should be taken to learn from children on how they view the world and what they think of work, labour and education.

Lard, Lice and Longevity reconstructs economic policies implemented in Denmark and the Netherlands during the German occupation. It clearly shows that the experiences of both these countries during World War I, and during the 1930s equipped them to introduce extensive and intrusive economic controls to ward off a subsistence crisis. In spite of the strong similarities between the two countries in terms of policies and economic order, there remains a glaring difference between the two. Throughout the occupation years, the Netherlands suffered a markedly higher level of child mortality than before or after the war, caused by an upsurge of infectious diseases. Child health in Denmark, on the other hand, declined during the occupation years, and infectious diseases rose only marginally there. In spite of similar policies, hence, the outcome in terms of the biological standard of living was dissimilar. By closely investigating the impact of various policies on everyday life, and the amounts of goods available to different groups of consumers, this study identifies the causes of this remarkable divergence.

Background: Many countries face substitution from formal to informal care. It is essential that a sufficient number of caregivers, such as family, friends or neighbors, are willing and able to lend care to address the needs of ill or elderly persons. We investigated whether the general public, who might become caregivers in the future, and current informal caregivers align with the shift to more informal caregiving. Methods: We studied the views on the responsibility for care of the general public versus the government, and whether these views differed among groups with diverse past experiences with care in terms of own health problems or previous caregiving activities. Data (n = 1097) was collected among the Dutch Health Care Consumer Panel with a survey in October 2015. Multivariate analyses of the views on responsibility for care in general and for different types of care were performed using (i) health, (ii) informal care, and (iii) general background characteristics, among a sample of the general public and among a subgroup of current caregivers. Results: The majority (67%) of the respondents would be willing to provide informal care in the future, when necessary. Respondents were more willing to provide support tasks than personal or nursing care activities. Among current caregivers, views on responsibility for care were associated with their past experience. Experiencing less burden of caregiving was associated with perceiving the general public as more responsible for personal or nursing care. Conclusions: The results of this study show that substitution from formal to informal care is more in line with public views when support activities are concerned than personal or nursing care. In addition, burdened caregivers also consider the government more responsible for personal or nursing care. When handing over care tasks to the public domain a critical view is needed on which care tasks are most appropriate for this.

Conditional marketing authorization (CMA) in the European Union (EU) is an early access pathway for medicines that show promising therapeutic effects, but for which comprehensive data are not available. Using a mixed quantitative-qualitative research design, we evaluated how CMA has been used in marketing authorization of oncology medicines in the period 2006 to 2013. We show that compared to full marketing authorization, CMA is granted based on less comprehensive data. However, this is accompanied by significantly longer assessment times and less consensus among regulators about marketing authorization. Moreover, development time from first-in-human testing to marketing authorization did not differ between full marketing authorization and CMA, but was significantly longer for CMA compared to accelerated approved products in the United States (US). Results indicate that CMA is not used by companies as a prospectively planned pathway to obtain early access, but as a "rescue option" when submitted data are not strong enough to justify full marketing authorization.