Initial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subsequent development of this early gut microbiota is driven and modulated by specific dietary compounds present in human milk that support selective colonization. This represents a very intriguing example of host-microbe co-evolution, where both partners are believed to benefit. In recent years, various publications have focused on dissecting microbial infant gut communities and their interaction with their human host, being a determining factor in host physiology and metabolic activities. Such studies have highlighted a reduction of microbial diversity and/or an aberrant microbiota composition, sometimes referred to as dysbiosis, which may manifest itself during the early stage of life, i.e., in infants, or later stages of life. There are growing experimental data that may explain how the early human gut microbiota affects risk factors related to adult health conditions. This concept has fueled the development of various nutritional strategies, many of which are based on probiotics and/or prebiotics, to shape the infant microbiota. In this review, we will present the current state of the art regarding the infant gut microbiota and the role of key commensal microorganisms like bifidobacteria in the establishment of the first microbial communities in the human gut. ; This work was primarily funded by the EU Joint Programming Initiative – A Healthy Diet for a Healthy Life (JPI HDHL, http://www.healthydietforhealthylife.eu/) to DvS (in conjunction with Science Foundation Ireland [SFI], Grant number 15/JP-HDHL/3280) and to MV (in conjunction with MIUR, Italy). D.v.S. is member of APC microbiome Ireland which is funded by SFI through the Irish Government's National Development Plan (Grant Numbers SFI/12/RC/2273-P1 and SFI/12/RC/2273-P2). The study is supported by Fondazione Cariparma, under TeachInParma Project (DV). ; Peer reviewed
KASCADE-Grande is an extensive air shower experiment devoted to the study of cosmic rays in the 1016 ÷ 1018 eV energy range. The array is composed by different detectors allowing independent measurements of the number of muons (Nμ) and charged particles (Nch) of extensive air showers (EAS). These two observables are then used to study the primary energy spectrum, separating the events in two samples, on the basis of the shower size ratio, corrected for attenuation in the atmosphere, lnNμ/ lnNch. The two samples represent the light and heavy mass groups of the primaries. In the studied energy range only the spectrum of heavy primaries shows a significant change of slope, the energy (estimated using the QGSJET II hadronic interaction model) of this feature is in agreeement with the expectations of a rigidity dependent knee feature.