Suchergebnisse

The health and nutritional status of a population of the hairy-nosed wombat Lasiorhinus latifrons
inhabiting the Blanche Town region of South Australia was assessed over a period of 18 months, 12 of
which were during a drought. Measurements were made of body morphology, haematological and
biochemical constituents and vitamin and trace element status of animals in the field: these were
examined in relation to the chemical composition of stomach contents and of faeces. During the study
period, changes in body weight, body condition and selected haematological and chemical constituents
were closely associated with changes in the quantity and quality of food, as measured by faecal nitrogen
and organic matter and by a plant growth index. It appears that wombats in the Blanche Town region
survived a drought of 12 months duration with minimal loss of body tissues and maintained
physiological functions.

Background: Dengue is an emerging public health problem in Tarai Region of Nepal. The most affected are among the poorest populations living in remote, rural areas and urban slums who have even no access for medical treatment. This study was carried out with the objective of the determining the serodiagnosis of dengue in symptomatic individuals and comparing it to IgM ELISA. Methods: One hundred eighty three samples were collected from the suspected cases having clinical symptoms of dengue in the Tarai region of Nepal during September to October 2007. Particle Agglutination (PA) assays was performed and it was compared with IgM capture ELISA. Results: Out of the total of 183 serum samples that 55(30%) samples were positive by PA assay. When compared with IgM-capture ELISA, a 50 of 55 were positive (sensitivity of 98% and specificity of 96%; a positive prediction value of 90% and negative prediction value of 99%). Conclusions: The finding of this study showed that dengue is firmly established in low endemic Tarai region of Nepal. The sensitivity and specificity of PA assay is acceptably high and will be useful in rural areas of Nepal. Key words: Dengue, Tarai region, Particle agglutination test, IgM capture ELISA DOI: 10.3126/jnhrc.v7i1.2276 Journal of Nepal Health Research Council Vol. 7, No. 1, 2009 April 29-32

Background Conduct, anxiety, and depressive disorders account for over 75% of the adolescent mental health burden globally. The current protocol will test a low-intensity problem-solving intervention for school-going adolescents with common mental health problems in India. The protocol also tests the effects of a classroom-based sensitization intervention on the demand for counselling services in an embedded recruitment trial. Methods/design We will conduct a two-arm, individually randomized controlled trial in six Government-run secondary schools in New Delhi. The targeted sample is 240 adolescents in grades 9–12 with persistent, elevated mental health symptoms and associated distress/impairment. Participants will receive either a brief problem-solving intervention delivered over 3 weeks by lay counsellors (intervention) or enhanced usual care comprised of problem-solving booklets (control). Self-reported adolescent mental health symptoms and idiographic problems will be assessed at 6 weeks (co-primary outcomes) and again at 12 weeks post-randomization. In addition, adolescent-reported distress/impairment, perceived stress, mental wellbeing, and clinical remission, as well as parent-reported adolescent mental health symptoms and impact scores, will be assessed at 6 and 12 weeks post-randomization. We will also complete a parallel process evaluation, including estimations of the costs of delivering the interventions. An embedded recruitment trial will apply a stepped-wedge, cluster (class)-randomized controlled design in 70 classes across the six schools. This will evaluate the added effect of a classroom-based sensitization intervention over and above school-level sensitization activities on the primary outcome of referral rate into the host trial. Other outcomes will be the proportion of referrals eligible to participate in the host trial, proportion of self-generated referrals, and severity and pattern of symptoms among referred adolescents in each condition. Power calculations were undertaken separately for ...

Whilst it is increasingly recognised that socio-political contexts shape climate change adaptation decisions and actions at all scales, current modes of development typically fail to recognise or adequately challenge these contexts where they constrain capacity to adapt. To address this failing, we consider how a rights-based approach broadens understanding of adaptive capacity while directing attention towards causes of exclusion and marginalisation. Drawing on human rights principles and lessons from rights-based practice, we develop a novel analytical tool for use with communities that considers adaptive capacity through examination of equality, transparency, accountability and empowerment. We apply this to the illustrative case of aquatic agricultural systems in Timor-Leste. This approach yields a qualitative analysis that unpacks the formal and informal institutions and actors that structure opportunities and barriers to adaptive actions. The rights framing exposes the processes of marginalisation and exclusion that lead to differentiation in adaptive capacity, but at the same time helps identify concrete actions that can be taken as part of a rights-based approach to development support for adaptive capacity. The tool and empirical illustration support an emerging body of thought that adaptive capacity requires development actors to engage not only with the technical challenges of responding to climate change, but also with the social and political context that determines the distribution of costs and benefits.

Background Most countries have endorsed WHO non-communicable disease (NCD) best buy policies, but we know very little about global implementation patterns and about the geopolitical factors affecting implementation. We aimed to assess global implementation based on analysis of multiple geopolitical datasets. Methods We used the 2015 and 2017 WHO NCD progress monitor reports to calculate aggregate implementation scores for 151 countries, based on their implementation of 18 WHO-recommended NCD policies. We ranked all countries and used descriptive statistics to analyse global trends. We used linear regression to assess the associations between policy implementation and World Bank geographic region, risk of premature NCD mortality, percentage of all deaths caused by NCDs, World Bank income group, human capital index, democracy index, and tax burden. Findings In 2017, the mean NCD policy implementation score was 49·3% (SD 18·4%). Costa Rica and Iran had the joint-highest implementation scores (86·1% of all WHO-recommended policies). Scores were lowest in Haiti and South Sudan (5·5%). Between 2015 and 2017, aggregate implementation scores rose in 109 countries and regressed in 32 countries. Mean implementation rose for all of the 18 policies except for those targeting alcohol and physical activity. The most commonly implemented policies were clinical guidelines, graphic warnings on tobacco packaging, and NCD risk factor surveys. Our multiple linear regression model explained 61·1% of the variance in 2017 aggregate scores (p<0·0001), but we found evidence of a high degree of collinearity between the explanatory variables. Interpretation Implementation of WHO-recommended NCD policies is increasing over time. On average, countries implemented just under half of the NCD policies recommended by WHO in 2017. Nutrition-related policies saw gains, while those related to alcohol and physical activity were the most likely to have been dropped. Aggregate implementation scores tended to be highest in high-income countries ...

© 2014 Published by Elsevier Ltd. All rights reserved. Coastal environments are increasingly under threat from multiple stressors and pressure from human activities across the land-sea interface. Managing these pressures from people requires, more than ever, understanding what is at stake in terms of the benefits and values associated with coastal waters. This article presents the results of a choice experiment which was designed to elicit society's willingness to pay in the context of economic and environmental trade-offs people to improve coastal water quality. The study site is a coastal Australian city, Adelaide, South Australia. The city discharges a large proportion of its stormwater and treated wastewater to the coastal waters of Gulf St Vincent. Willingness to pay for a package of improvements to urban water management is considerable. A mix of projects that restores 25 days per year of water clarity, seagrass area from 60% to 70% of the original area and five reef areas is worth $AUS67.1. M to households in the Adelaide metropolitan area. The results can inform public policy discussions including the cost-benefit analysis of different water management strategies including investments in urban infrastructure.

Ultra-wideband (UWB) technology has increased with the use of various civilian and military applications. In the present study, we hypothesized that low-dose UWB electromagnetic radiation (UWBR) could elicit a mitogenic effect in AML-12 mouse hepatocytes, in vitro. To test this hypothesis, we exposed AML-12 mouse hepatocytes, to UWBR in a specially constructed gigahertz transverse electromagnetic mode (GTEM) cell. Cells were exposed to UWBR for 2 h at a temperature of 23 degrees C, a pulse width of 10 ns, a repetition rate of 1 kHz, and field strength of 5-20 kV/m. UWB pulses were triggered by an external pulse generator for UWBR exposure but were not triggered for the sham exposure. We performed an MTT Assay to assess cell viability for UWBR-treated and sham-exposed hepatocytes. Data from viability studies indicated a time-related increase in hepatocytes at time intervals from 8-24 h post exposure. UWBR exerted a statistically significant (p < 0.05) dose-dependent response in cell viability in both serum-treated and serum free medium (SFM) -treated hepatocytes. Western blot analysis of hepatocyte lysates demonstrated that cyclin A protein was induced in hepatocytes, suggesting that increased MTT activity after UWBR exposure was due to cell proliferation. This study indicates that UWBR has a mitogenic effect on AML-12 mouse hepatocytes and implicates a possible role for UWBR in hepatocarcinoma.

"Sonderdruck aus der Zeitschrift für Politik, Ix. Band, 1916, Heft 3/4." ; Includes bibliographical references. ; Mode of access: Internet.

Campaigns to circumcise millions of boys and men to reduce HIV transmission are being conducted throughout eastern and southern Africa, recommended by the World Health Organization and implemented by the United States government and Western NGOs. In the United States, proposals to mass-circumcise African and African American men are longstanding, and have historically relied on racist beliefs and stereotypes. The present campaigns were started in haste, without adequate contextual research, and the manner in which they have been carried out implies troubling assumptions about culture, health, and sexuality in Africa, as well as a failure to properly consider the economic determinants of HIV prevalence. This critical appraisal examines the history and politics of these circumcision campaigns while highlighting the relevance of race and colonialism. It argues that the "circumcision solution" to African HIV epidemics has more to do with cultural imperialism than with sound health policy, and concludes that African communities need a means of robust representation within the regime.

This study was undertaken to assess farmers' preferences and willingness to pay (WTP) for various climate-smart interventions in the Indo-Gangetic Plain. The research outputs will be helpful in integrating farmers' choices with government programs in the selected regions. The Indo-Gangetic Plain (IGP) was selected because it is highly vulnerable to climate change, which may adversely affect the sustainability of the rice-wheat production system and the food security of the region. Climate-smart agriculture (CSA) can mitigate the negative impacts of climate change and improve the efficiency of the rice-wheat-based production system. CSA requires a complete package of practices to achieve the desired objectives, but adoption is largely dependent on farmers' preferences and their capacity and WTP. To assess farmers' choices and their WTP for the potential climate-smart technologies and other interventions, we used scoring and bidding protocols implemented through focus group meetings in two distinct regions of Eastern and Western IGP. We find that laser land leveling (LLL), crop insurance, and weather advisory services were the preferred interventions in Eastern IGP. Farmers preferred LLL, direct seeding, zero tillage, irrigation scheduling, and crop insurance in Western IGP. Through the bidding approach, farmers implicitly express their WTP for new technologies that could transform current agricultural practices into relatively low-carbon and more productive farming methods. But actual large-scale adoption of the preferred climate-smart technologies and other interventions would require access to funding as well as capacity building among technology promoters and users.

Much of the western United States is managed by state and federal agencies for multiple uses, including recreation, grazing, extraction, and defense. Biological inventories are integral to proper management and conservation of biodiversity on these lands. We surveyed for amphibians and reptiles occurring on Naval Air Station Fallon (NAS Fallon), Nevada, USA, using a variety of methods. We documented the presence of a majority of the amphibian and reptile species native to this region of the Great Basin. We found 5 species on NAS Fallon that are listed as Species of Conservation Priority by the Nevada Department of Wildlife: the Great Basin Spadefoot (Spea intermontana), Western Toad (Anaxyrus boreas boreas), Northern Desert Horned Lizard (Phrynosoma platyrhinos platyrhinos), Long-nosed Leopard Lizard (Gambelia wizlizenii), and Great Basin Collared Lizard (Crotaphytus bicinctores). However, we found no evidence of any narrowly distributed species of conservation concern, such as the Northern Leopard Frog (Lithobates pipiens) or Northern Rubber Boa (Charina bottae), that could have occurred on installation lands based on historical or recent observations in nearby areas. Our results indicate that this property, while primarily used for military training, can support a diverse, representative herpetofaunal community. Therefore, NAS Fallon should be considered a valuable part of the network of state and federally managed lands necessary for regional conservation planning in the face of future change. Our study also provides a baseline against which future inventories of this federally managed land can be compared.

Much of the western United States is managed by state and federal agencies for multiple uses, including recreation, grazing, extraction, and defense. Biological inventories are integral to proper management and conservation of biodiversity on these lands. We surveyed for amphibians and reptiles occurring on Naval Air Station Fallon (NAS Fallon), Nevada, USA, using a variety of methods. We documented the presence of a majority of the amphibian and reptile species native to this region of the Great Basin. We found 5 species on NAS Fallon that are listed as Species of Conservation Priority by the Nevada Department of Wildlife: the Great Basin Spadefoot (Spea intermontana), Western Toad (Anaxyrus boreas boreas), Northern Desert Horned Lizard (Phrynosoma platyrhinos platyrhinos), Long-nosed Leopard Lizard (Gambelia wizlizenii), and Great Basin Collared Lizard (Crotaphytus bicinctores). However, we found no evidence of any narrowly distributed species of conservation concern, such as the Northern Leopard Frog (Lithobates pipiens) or Northern Rubber Boa (Charina bottae), that could have occurred on installation lands based on historical or recent observations in nearby areas. Our results indicate that this property, while primarily used for military training, can support a diverse, representative herpetofaunal community. Therefore, NAS Fallon should be considered a valuable part of the network of state and federally managed lands necessary for regional conservation planning in the face of future change. Our study also provides a baseline against which future inventories of this federally managed land can be compared.

Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and function after ischaemic insults in vitro, but its long-term cardioprotective actions in vivo are largely unknown. We tested the hypothesis that ANX-A1-deficiency exaggerates inflammation, haematopoietic stem progenitor cell (HSPC) activity and LV remodelling in response to myocardial ischaemia in vivo. Adult ANX - A1 -/- mice subjected to coronary artery occlusion exhibited increased infarct size and LV macrophage content after 24-48 h reperfusion compared with wildtype (WT) counterparts. In addition, ANX - A1 -/- mice exhibited greater expansion of HSPCs and altered pattern of HSPC mobilisation 8 days post-myocardial infarction, with increased circulating neutrophils and platelets, consistent with increased cardiac inflammation as a result of increased myeloid invading injured myocardium in response to MI. Furthermore, ANX - A1 -/- mice exhibited significantly increased expression of LV pro-inflammatory and pro-fibrotic genes and collagen deposition after MI compared to WT counterparts. ANX-A1-deficiency increased cardiac necrosis, inflammation, hypertrophy and fibrosis following MI, accompanied by exaggerated HSPC activity and impaired macrophage phenotype. These findings suggest that endogenous ANX-A1 regulates mobilisation and differentiation of HSPCs. Limiting excessive monocyte/neutrophil production may limit LV damage in vivo. Our findings support further development of novel ANX-A1-based therapies to improve cardiac outcomes after MI. ; This work was supported in part by both the National Health and Medical Research Council (NHMRC) of Australia, including APP1045140 (to R.H.R., X.M.G., Y.H.Y.), APP1083138 & APP1106154 (to A.J.M.), and the Victorian Government's Operational Infrastructure Support Program. R.H.R. and X.J.D. are NHMRC Senior Research Fellows (APP1059960; APP1043026 respectively), A.J.M. is an NHMRC Career Development Fellow (APP1085752) and a NHF Future Leader Fellow (100440). A.A.S. and S.B.F. are supported by Australian Postgraduate Awards.

Background: COPD is among the leading causes of chronic morbidity and mortality in the European Union with an estimated annual economic burden of €25.1 billion. Various care pathways for COPD exist across Europe leading to different responses to similar problems. Determining these differences and the similarities may improve health and the functioning of health services. Objective: The aim of this study was to compare COPD patients' care pathway in five European Union countries including England, Ireland, the Netherlands, Greece, and Germany and to explore health care professionals' (HCPs) perceptions about the current pathways. Methods: HCPs were interviewed in two stages using a qualitative, semistructured email interview and a face-to-face semistructured interview. Results: Lack of communication among different health care providers managing COPD and comorbidities was a common feature of the studied care pathways. General practitioners/family doctors are responsible for liaising between different teams/services, except in Greece where this is done through pulmonologists. Ireland and the UK are the only countries with services for patients at home to shorten unnecessary hospital stay. HCPs emphasized lack of communication, limited resources, and poor patient engagement as issues in the current pathways. Furthermore, no specified role exists for pharmacists and informal carers. Conclusion: Service and professional integration between care settings using a unified system targeting COPD and comorbidities is a priority. Better communication between health care providers, establishing a clear role for informal carers, and enhancing patients' engagement could optimize current care pathways resulting in a better integrated system.