In: Ruggeri , K , Veckalov , B , Bojanic , L , Andersen , T L , Ashcroft-Jones , S , Ayacaxli , N , Barea-Arroyo , P , Berge , M L , Bjorndal , L D , Bursalioglu , A , Buhler , V , Cadek , M , cetincelik , M , Clay , G , Cortijos-Bernabeu , A , Damnjanovic , K , Dugue , T M , Esberg , M , Esteban-Serna , C , Felder , E N , Friedemann , M , Frontera-Villanueva , D I , Gale , P , Garcia-Garzon , E , Geiger , S J , George , L , Girardello , A , Gracheva , A , Gracheva , A , Guillory , M , Hecht , M , Herte , K , Hubena , B , Ingalls , W , Jakob , L , Janssens , M , Jarke , H , Kacha , O , Kalinova , K N , Karakasheva , R , Khorrami , P R , Lep , Z , Lins , S , Lofthus , I S , Mamede , S , Mareva , S , Mascarenhas , M F , McGill , L , Morales-Izquierdo , S , Moltrecht , B , Mueller , T S , Musetti , M , Nelsson , J , Otto , T , Paul , A F , Pavlovic , I , Petrovic , M B , Popovic , D , Prinz , G M , Razum , J , Sakelariev , I , Samuels , V , Sanguino , I , Say , N , Schuck , J , Soysal , I , Todsen , A L , Tunte , M R , Vdovic , M , Vintr , J , Vovko , M , Vranka , M A , Wagner , L , Wilkins , L , Willems , M , Wisdom , E , Yosifova , A , Zeng , S , Ahmed , M A , Dwarkanath , T , Cikara , M , Lees , J & Folke , T 2021 , ' The general fault in our fault lines ' , Nature Human Behaviour , vol. 5 , no. 10 , pp. 1369-1380 . https://doi.org/10.1038/s41562-021-01092-x ; ISSN:2397-3374
Ruggeri et al. tested perceptions of opposing political party members in 10,207 participants from 26 countries. Results show that beliefs about others are overly negative but could be more realistic with transparency about actual group beliefs. Pervading global narratives suggest that political polarization is increasing, yet the accuracy of such group meta-perceptions has been drawn into question. A recent US study suggests that these beliefs are inaccurate and drive polarized beliefs about out-groups. However, it also found that informing people of inaccuracies reduces those negative beliefs. In this work, we explore whether these results generalize to other countries. To achieve this, we replicate two of the original experiments with 10,207 participants across 26 countries. We focus on local group divisions, which we refer to as fault lines. We find broad generalizability for both inaccurate meta-perceptions and reduced negative motive attribution through a simple disclosure intervention. We conclude that inaccurate and negative group meta-perceptions are exhibited in myriad contexts and that informing individuals of their misperceptions can yield positive benefits for intergroup relations. Such generalizability highlights a robust phenomenon with implications for political discourse worldwide.
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
Background: It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28). Methods: This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (V-T) was defined as V-T = 5 cmH(2)O; 80% of patients had maximum airway pressures <30 cmH(2)O. Conclusion: In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients, irrespective of the presence of inhalation trauma. Use of low V-T was not associated with a reduction in VFD-28. ; Funding Agencies|Nederlandse Brandwonden Stichting (the Dutch Burn Association, Beverwijk, The Netherlands)Netherlands Government
ABSTRACT Objective: There are over 4000 trials conducted in people with COVID-19. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of this study was to generate a consensus-based, prioritized list of outcomes for COVID-19 trials. Design: In an online survey conducted in English, Chinese, Italian, Portuguese and Spanish languages, adults with COVID-19, their family members, health professionals and the general public rated the importance of outcomes using a 9-point Likert scale (7-9, critical importance) and completed a Best-Worst Scale to estimate relative importance. Participant comments were analysed thematically. Setting: International Participants: Adults aged 18 years and over with confirmed or suspected COVID-19, their family members, members of the general public and health professionals (including clinicians, policy makers, regulators, funders, researchers). Main Results: In total, 9289 participants from 111 countries (776 people with COVID-19 or family members, 4882 health professionals, and 3631 members of the public) completed the survey. The four outcomes of highest priority for all three groups were: mortality, respiratory failure, pneumonia and organ failure. Lung function, lung scarring, sepsis, shortness of breath, and oxygen level in the blood were common to the top 10 outcomes across all three groups (mean >7.5, median ≥ 8, and >70% of respondents rated the outcome as critically important). Patients/family members rated fatigue, anxiety, chest pain, muscle pain, gastrointestinal problems and cardiovascular disease higher than health professionals. Four themes underpinned prioritization: fear of life-threatening, debilitating and permanent consequences; addressing knowledge gaps; enabling preparedness and planning; and tolerable or infrequent outcomes. Conclusions: Life-threatening respiratory and other organ outcomes were consistently highly prioritized by all stakeholder groups. Patients/family members gave higher priority to many patient-reported outcomes compared with health professionals. ; The project is funded by the Flinders University and the National COVID-19 Clinical Evidence Taskforce, convened by the Australian Living Evidence Consortium, hosted by Cochrane Australia, School of Public Health and Preventive Medicine, Monash University supported by the Australian Government, Victorian Department of Health and Human Services, Ian Potter Foundation, Walter Cottman Endowment Fund (managed by Equity Trustees) and the Lord Mayor's Charitable Foundation). AT is supported by The University of Sydney Robinson Fellowship. ACM is supported by a Clinical Research Career Development Fellowship from the Wellcome Trust (WT 2055214/Z/16/Z)
In: Brundage , M , Avin , S , Wang , J , Belfield , H , Krueger , G , Hadfield , G , Khlaaf , H , Yang , J , Toner , H , Fong , R , Maharaj , T , Koh , P W , Hooker , S , Leung , J , Trask , A , Bluemke , E , Lebensold , J , O'Keefe , C , Koren , M , Ryffel , T , Rubinovitz , JB , Besiroglu , T , Carugati , F , Clark , J , Eckersley , P , Haas , S D , Johnson , M , Laurie , B , Ingerman , A , Krawczuk , I , Askell , A , Cammarota , R , Lohn , A , Krueger , D , Stix , C , Henderson , P , Graham , L , Prunkl , C , Martin , B , Seger , E , Zilberman , N , hÉigeartaigh , S Ó , Kroeger , F , Sastry , G , Kagan , R , Weller , A , Tse , B , Barnes , E , Dafoe , A , Scharre , P , Herbert-Voss , A , Rasser , M , Sodhani , S , Flynn , C , Gilbert , T K , Dyer , L , Khan , S , Bengio , Y & Anderljung , M 2020 , ' Toward Trustworthy AI Development: Mechanisms for Supporting Verifiable Claims ' , arXiv.org, e-Print Archive, Mathematics .
With the recent wave of progress in artificial intelligence (AI) has come a growing awareness of the large-scale impacts of AI systems, and recognition that existing regulations and norms in industry and academia are insufficient to ensure responsible AI development. In order for AI developers to earn trust from system users, customers, civil society, governments, and other stakeholders that they are building AI responsibly, they will need to make verifiable claims to which they can be held accountable. Those outside of a given organization also need effective means of scrutinizing such claims. This report suggests various steps that different stakeholders can take to improve the verifiability of claims made about AI systems and their associated development processes, with a focus on providing evidence about the safety, security, fairness, and privacy protection of AI systems. We analyze ten mechanisms for this purpose--spanning institutions, software, and hardware--and make recommendations aimed at implementing, exploring, or improving those mechanisms.
Government and nongovernmental organizations need national and global estimates on the descriptive epidemiology of common oral conditions for policy planning and evaluation. The aim of this component of the Global Burden of Disease study was to produce estimates on prevalence, incidence, and years lived with disability for oral conditions from 1990 to 2017 by sex, age, and countries. In addition, this study reports the global socioeconomic pattern in burden of oral conditions by the standard World Bank classification of economies as well as the Global Burden of Disease Socio-demographic Index. The findings show that oral conditions remain a substantial population health challenge. Globally, there were 3.5 billion cases (95% uncertainty interval [95% UI], 3.2 to 3.7 billion) of oral conditions, of which 2.3 billion (95% UI, 2.1 to 2.5 billion) had untreated caries in permanent teeth, 796 million (95% UI, 671 to 930 million) had severe periodontitis, 532 million (95% UI, 443 to 622 million) had untreated caries in deciduous teeth, 267 million (95% UI, 235 to 300 million) had total tooth loss, and 139 million (95% UI, 133 to 146 million) had other oral conditions in 2017. Several patterns emerged when the World Bank's classification of economies and the Socio-demographic Index were used as indicators of economic development. In general, more economically developed countries have the lowest burden of untreated dental caries and severe periodontitis and the highest burden of total tooth loss. The findings offer an opportunity for policy makers to identify successful oral health strategies and strengthen them; introduce and monitor different approaches where oral diseases are increasing; plan integration of oral health in the agenda for prevention of noncommunicable diseases; and estimate the cost of providing universal coverage for dental care.
In: Wilemon , K A , Patel , J , Aguilar-Salinas , C , Ahmed , C D , Alkhnifsawi , M , Almahmeed , W , Alonso , R , Al-Rasadi , K , Badimon , L , Bernal , L M , Bogsrud , M P , Braun , L T , Brunham , L , Catapano , A L , Čillíková , K , Corral , P , Cuevas , R , Defesche , J C , Descamps , O S , De Ferranti , S , Eiselé , J L , Elikir , G , Folco , E , Freiberger , T , Fuggetta , F , Gaspar , I M , Gesztes , Á G , Grošelj , U , Hamilton-Craig , I , Hanauer-Mader , G , Harada-Shiba , M , Hastings , G , Hovingh , G K , Izar , M C , Jamison , A , Karlsson , G N , Kayikçioǧlu , M , Koob , S , Koseki , M , Lane , S , Lima-Martinez , M M , López , G , Martinez , T L , Marais , D , Marion , L , Mata , P , Maurina , I , Maxwell , D , Mehta , R , Nordestgaard , B G & Global Familial Hypercholesterolemia Community 2020 , ' Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia : A Global Call to Action ' , JAMA Cardiology , vol. 5 , no. 2 , pp. 217-229 . https://doi.org/10.1001/jamacardio.2019.5173
Importance: Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated genetic disorder that leads to premature morbidity and mortality due to atherosclerotic cardiovascular disease. Familial hypercholesterolemia affects 1 in 200 to 250 people around the world of every race and ethnicity. The lack of general awareness of FH among the public and medical community has resulted in only 10% of the FH population being diagnosed and adequately treated. The World Health Organization recognized FH as a public health priority in 1998 during a consultation meeting in Geneva, Switzerland. The World Health Organization report highlighted 11 recommendations to address FH worldwide, from diagnosis and treatment to family screening and education. Research since the 1998 report has increased understanding and awareness of FH, particularly in specialty areas, such as cardiology and lipidology. However, in the past 20 years, there has been little progress in implementing the 11 recommendations to prevent premature atherosclerotic cardiovascular disease in an entire generation of families with FH. Observations: In 2018, the Familial Hypercholesterolemia Foundation and the World Heart Federation convened the international FH community to update the 11 recommendations. Two meetings were held: one at the 2018 FH Foundation Global Summit and the other during the 2018 World Congress of Cardiology and Cardiovascular Health. Each meeting served as a platform for the FH community to examine the original recommendations, assess the gaps, and provide commentary on the revised recommendations. The Global Call to Action on Familial Hypercholesterolemia thus represents individuals with FH, advocacy leaders, scientific experts, policy makers, and the original authors of the 1998 World Health Organization report. Attendees from 40 countries brought perspectives on FH from low-, middle-, and high-income regions. Tables listing country-specific government support for FH care, existing country-specific and international FH scientific ...
The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis. These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation. Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers. Researchers are provided with their own secure 'lab' using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts. Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.
BACKGROUND: Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance. METHODS: In this multicentre, open-label, randomised trial, we recruited patients with uncomplicated P falciparum malaria at 18 hospitals and health clinics in eight countries. Eligible patients were aged 2–65 years, with acute, uncomplicated P falciparum malaria alone or mixed with non-falciparum species, and a temperature of 37·5°C or higher, or a history of fever in the past 24 h. Patients were randomly assigned (1:1) to one of two treatments using block randomisation, depending on their location: in Thailand, Cambodia, Vietnam, and Myanmar patients were assigned to either dihydroartemisinin–piperaquine or dihydroartemisinin–piperaquine plus mefloquine; at three sites in Cambodia they were assigned to either artesunate–mefloquine or dihydroartemisinin–piperaquine plus mefloquine; and in Laos, Myanmar, Bangladesh, India, and the Democratic Republic of the Congo they were assigned to either artemether–lumefantrine or artemether–lumefantrine plus amodiaquine. All drugs were administered orally and doses varied by drug combination and site. Patients were followed-up weekly for 42 days. The primary endpoint was efficacy, defined by 42-day PCR-corrected adequate clinical and parasitological response. Primary analysis was by intention to treat. A detailed assessment of safety and tolerability of the study drugs was done in all patients randomly assigned to treatment. This study is registered at ClinicalTrials.gov, NCT02453308, and is complete. FINDINGS: Between Aug 7, 2015, and Feb 8, 2018, 1100 patients were given either dihydroartemisinin–piperaquine (183 [17%]), dihydroartemisinin–piperaquine plus mefloquine (269 [24%]), artesunate–mefloquine (73 ...
Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement. ; Partly funded by POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), and ...
International audience ; Background : In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body : As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion : In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
In: Bousquet , J J , Schünemann , H J , Togias , A , Erhola , M , Hellings , P W , Zuberbier , T , Agache , I , Ansotegui , I J , Anto , J M , Bachert , C , Becker , S , Bedolla-Barajas , M , Bewick , M , Bosnic-Anticevich , S , Bosse , I , Boulet , L P , Bourrez , J M , Brusselle , G , Chavannes , N , Costa , E , Cruz , A A , Czarlewski , W , Fokkens , W J , Fonseca , J A , Gaga , M , Haahtela , T , Illario , M , Klimek , L , Kuna , P , Kvedariene , V , Le , L T T , Larenas-Linnemann , D , Laune , D , Lourenço , O M , Menditto , E , Mullol , J , Okamoto , Y , Papadopoulos , N , Pham-Thi , N , Picard , R , Pinnock , H , Roche , N , Roller-Wirnsberger , R E , Rolland , C , Samolinski , B , Sheikh , A , Toppila-Salmi , S , Tsiligianni , I , Valiulis , A , Valovirta , E , Vasankari , T , Ventura , M T , Walker , S , Williams , S , Akdis , C A , Annesi-Maesano , I , Arnavielhe , S , Basagana , X , Bateman , E , Bedbrook , A , Bennoor , K S , Benveniste , S , Bergmann , K C , Bialek , S , Billo , N , Bindslev-Jensen , C , Bjermer , L , Blain , H , Bonini , M , Bonniaud , P , Bouchard , J , Briedis , V , Brightling , C E , Brozek , J , Buhl , R , Buonaiuto , R , Canonica , G W , Cardona , V , Carriazo , A M , Carr , W , Cartier , C , Casale , T , Cecchi , L , Cepeda Sarabia , A M , Chkhartishvili , E , Chu , D K , Cingi , C , Colgan , E , De Sousa , J C , Courbis , A L , Custovic , A , Cvetkosvki , B , Damato , G , Da Silva , J , Dantas , C , Dokic , D , Dauvilliers , Y , Dedeu , A , De Feo , G , Devillier , P , Di Capua , S , Dykewickz , M , Dubakiene , R , Ebisawa , M , El-Gamal , Y , Eller , E , Emuzyte , R , Farrell , J , Fink-Wagner , A , Fiocchi , A , Fontaine , J F , Gemicioǧlu , B , Schmid-Grendelmeir , P , Gamkrelidze , A , Garcia-Aymerich , J , Gomez , M , Diaz , S G , Gotua , M , Guldemond , N A , Guzmán , M A , Hajjam , J , O'Hourihane , J B , Humbert , M , Iaccarino , G , Ierodiakonou , D , Ivancevich , J C , Joos , G , Jung , K S , Jutel , M , Kaidashev , I , Kalayci , O , Kardas , P , Keil , T , Khaitov , M , Khaltaev , N , Kleine-Tebbe , J , Kowalski , M L , Kritikos , V , Kull , I , Leonardini , L , Lieberman , P , Lipworth , B , Lodrup Carlsen , K C , Loureiro , C C , Louis , R , Mair , A , Marien , G , Mahboub , B , Malva , J , Manning , P , De Manuel Keenoy , E , Marshall , G D , Masjedi , M R , Maspero , J F , Mathieu-Dupas , E , Matricardi , P M , Melén , E , Melo-Gomes , E , Meltzer , E O , Mercier , J , Miculinic , N , Mihaltan , F , Milenkovic , B , Moda , G , Mogica-Martinez , M D , Mohammad , Y , Montefort , S , Monti , R , Morais-Almeida , M , Mösges , R , Münter , L , Muraro , A , Murray , R , Naclerio , R , Napoli , L , Namazova-Baranova , L , Neffen , H , Nekam , K , Neou , A , Novellino , E , Nyembue , D , O'Hehir , R , Ohta , K , Okubo , K , Onorato , G , Ouedraogo , S , Pali-Schöll , I , Palkonen , S , Panzner , P , Park , H S , Pépin , J L , Pereira , A M , Pfaar , O , Paulino , E , Phillips , J , Plavec , D , Popov , T A , Portejoie , F , Price , D , Prokopakis , E P , Pugin , B , Raciborski , F , Rajabian-Söderlund , R , Reitsma , S , Rodo , X , Romano , A , Rosario , N , Rottem , M , Ryan , D , Salimäki , J , Sanchez-Borges , M M , Sisul , J C , Solé , D , Somekh , D , Sooronbaev , T , Sova , M , Spranger , O , Stellato , C , Stelmach , R , Ulrik , C S , Thibaudon , M , To , T , Todo-Bom , A , Tomazic , P V , Valero , A A , Valenta , R , Valentin-Rostan , M , Van Der Kleij , R , Vandenplas , O , Vezzani , G , Viart , F , Viegi , G , Wallace , D , Wagenmann , M , Wang , D Y , Waserman , S , Wickman , M , Williams , D M , Wong , G , Wroczynski , P , Yiallouros , P K , Yorgancioglu , A , Yusuf , O M , Zar , H J , Zeng , S , Zernotti , M , Zhang , L , Zhong , N S & Zidarn , M 2019 , ' Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases ' , Clinical and Translational Allergy , vol. 9 , 44 . https://doi.org/10.1186/s13601-019-0279-2
Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhi-nitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
BackgroundIn all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main bodyAs an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care.ConclusionIn 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
In: Bousquet , J J , Schünemann , H J , Togias , A , Erhola , M , Hellings , P W , Zuberbier , T , Agache , I , Ansotegui , I J , Anto , J M , Bachert , C , Becker , S , Bedolla-Barajas , M , Bewick , M , Bosnic-Anticevich , S , Bosse , I , Boulet , L P , Bourrez , J M , Brusselle , G , Chavannes , N , Costa , E , Cruz , A A , Czarlewski , W , Fokkens , W J , Fonseca , J A , Gaga , M , Haahtela , T , Illario , M , Klimek , L , Kuna , P , Kvedariene , V , Le , L T T , Larenas-Linnemann , D , Laune , D , Lourenço , O M , Menditto , E , Mullol , J , Okamoto , Y , Papadopoulos , N , Pham-Thi , N , Picard , R , Pinnock , H , Roche , N , Roller-Wirnsberger , R E , Rolland , C , Samolinski , B , Sheikh , A , Toppila-Salmi , S , Tsiligianni , I , Valiulis , A , Valovirta , E , Vasankari , T , Ventura , M T , Walker , S , Williams , S , Akdis , C A , Annesi-Maesano , I , Arnavielhe , S , Basagana , X , Bateman , E , Bedbrook , A , Bennoor , K S , Benveniste , S , Bergmann , K C , Bialek , S , Billo , N , Bindslev-Jensen , C , Bjermer , L , Blain , H , Bonini , M , Bonniaud , P , Bouchard , J , Briedis , V , Brightling , C E , Brozek , J , Buhl , R , Buonaiuto , R , Canonica , G W , Cardona , V , Carriazo , A M , Carr , W , Cartier , C , Casale , T , Cecchi , L , Cepeda Sarabia , A M , Chkhartishvili , E , Chu , D K , Cingi , C , Colgan , E , De Sousa , J C , Courbis , A L , Custovic , A , Cvetkosvki , B , Damato , G , Da Silva , J , Dantas , C , Dokic , D , Dauvilliers , Y , Dedeu , A , De Feo , G , Devillier , P , Di Capua , S , Dykewickz , M , Dubakiene , R , Ebisawa , M , El-Gamal , Y , Eller , E , Emuzyte , R , Farrell , J , Fink-Wagner , A , Fiocchi , A , Fontaine , J F , Gemicioǧlu , B , Schmid-Grendelmeir , P , Gamkrelidze , A , Garcia-Aymerich , J , Gomez , M , Diaz , S G , Gotua , M , Guldemond , N A , Guzmán , M A , Hajjam , J , O'Hourihane , J B , Humbert , M , Iaccarino , G , Ierodiakonou , D , Ivancevich , J C , Joos , G , Jung , K S , Jutel , M , Kaidashev , I , Kalayci , O , Kardas , P , Keil , T , Khaitov , M , Khaltaev , N , Kleine-Tebbe , J , Kowalski , M L , Kritikos , V , Kull , I , Leonardini , L , Lieberman , P , Lipworth , B , Lodrup Carlsen , K C , Loureiro , C C , Louis , R , Mair , A , Marien , G , Mahboub , B , Malva , J , Manning , P , De Manuel Keenoy , E , Marshall , G D , Masjedi , M R , Maspero , J F , Mathieu-Dupas , E , Matricardi , P M , Melén , E , Melo-Gomes , E , Meltzer , E O , Mercier , J , Miculinic , N , Mihaltan , F , Milenkovic , B , Moda , G , Mogica-Martinez , M D , Mohammad , Y , Montefort , S , Monti , R , Morais-Almeida , M , Mösges , R , Münter , L , Muraro , A , Murray , R , Naclerio , R , Napoli , L , Namazova-Baranova , L , Neffen , H , Nekam , K , Neou , A , Novellino , E , Nyembue , D , O'Hehir , R , Ohta , K , Okubo , K , Onorato , G , Ouedraogo , S , Pali-Schöll , I , Palkonen , S , Panzner , P , Park , H S , Pépin , J L , Pereira , A M , Pfaar , O , Paulino , E , Phillips , J , Plavec , D , Popov , T A , Portejoie , F , Price , D , Prokopakis , E P , Pugin , B , Raciborski , F , Rajabian-Söderlund , R , Reitsma , S , Rodo , X , Romano , A , Rosario , N , Rottem , M , Ryan , D , Salimäki , J , Sanchez-Borges , M M , Sisul , J C , Solé , D , Somekh , D , Sooronbaev , T , Sova , M , Spranger , O , Stellato , C , Stelmach , R , Ulrik , C S , Thibaudon , M , To , T , Todo-Bom , A , Tomazic , P V , Valero , A A , Valenta , R , Valentin-Rostan , M , Van Der Kleij , R , Vandenplas , O , Vezzani , G , Viart , F , Viegi , G , Wallace , D , Wagenmann , M , Wang , D Y , Waserman , S , Wickman , M , Williams , D M , Wong , G , Wroczynski , P , Yiallouros , P K , Yorgancioglu , A , Yusuf , O M , Zar , H J , Zeng , S , Zernotti , M , Zhang , L , Zhong , N S , Zidarn , M , the ARIA Study Group & the MASK Study Group 2019 , ' Next-generation ARIA care pathways for rhinitis and asthma : A model for multimorbid chronic diseases ' , Clinical and Translational Allergy , vol. 9 , no. 1 , 44 . https://doi.org/10.1186/s13601-019-0279-2
Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhi-nitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
In: Bousquet , J J , Schünemann , H J , Togias , A , Erhola , M , Hellings , P W , Zuberbier , T , Agache , I , Ansotegui , I J , Anto , J M , Bachert , C , Becker , S , Bedolla-Barajas , M , Bewick , M , Bosnic-Anticevich , S , Bosse , I , Boulet , L P , Bourrez , J M , Brusselle , G , Chavannes , N , Costa , E , Cruz , A A , Czarlewski , W , Fokkens , W J , Fonseca , J A , Gaga , M , Haahtela , T , Illario , M , Klimek , L , Kuna , P , Kvedariene , V , Le , L T T , Larenas-Linnemann , D , Laune , D , Lourenço , O M , Menditto , E , Mullol , J , Okamoto , Y , Papadopoulos , N , Pham-Thi , N , Picard , R , Pinnock , H , Roche , N , Roller-Wirnsberger , R E , Rolland , C , Samolinski , B , Sheikh , A , Toppila-Salmi , S , Tsiligianni , I , Bindslev-Jensen , C , Eller , E , Ulrik , C S & ARIA Study Group 2019 , ' Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases ' , Clinical and Translational Allergy , vol. 9 , 44 . https://doi.org/10.1186/s13601-019-0279-2
Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
