Suchergebnisse

Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- Mil.g. 368 f

Background: C3-Cloud is an integrated care ICT infrastructure offering seamless patient-centered approach to managing multimorbidity, deployed in three European pilot sites. Challenge: The digital delivery of best practice guidelines unified for multimorbidity, customized to local practice, offering the capability to improve patient personalization and benefit. Method: C3-Cloud has adopted a co-production approach to developing unified multimorbidity guidelines, by collating and reconciling best practice guidelines for each condition. Clinical and technical teams at pilot sites and the C3-Cloud consortium worked in tandem to create the specification and technical implementation. Results: C3-Cloud offers CDSS for diabetes, renal failure, depression and congenital heart failure, with over 300 rules and checks that deliver four best practice guidelines in parallel, customized for each pilot site. Conclusions: The process provided a traceable, maintainable and audited digitally delivered collated and reconciled guidelines.

uebers. u. mit Anm. begl. von Johann Karl Höck ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- J.can.p. 614 n-4

uebers. u. mit Anm. begl. von Johann Karl Höck ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- J.can.p. 614 n-3

uebers. u. mit Anm. begl. von Johann Karl Höck ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- J.can.p. 614 n-2

uebers. u. mit Anm. begl. von Johann Karl Höck ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- J.can.p. 614 n-1

Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- Math.p. 326 sa

Vitamin D is essential for bone health and is known to be involved in immunomodulation and cell proliferation. Vitamin D status remains a significant health issue worldwide. However, there has been no clear consensus on vitamin D deficiency and its measurement in serum, and clinical practice of vitamin D deficiency treatment remains inconsistent. The major circulating metabolite of vitamin D, 25-hydroxyvitamin D (25(OH)D), is widely used as a biomarker of vitamin D status. Other metabolic pathways are recognised as important to vitamin D function and measurement of other metabolites may become important in the future. The utility of free 25(OH)D rather than total 25(OH)D needs further assessment. Data used to estimate the vitamin D intake required to achieve a serum 25(OH)D concentration were drawn from individual studies which reported dose-response data. The studies differ in their choice of subjects, dose of vitamin D, frequency of dosing regimen and methods used for the measurement of 25(OH)D concentration. Baseline 25(OH)D, body mass index, ethnicity, type of vitamin D (D(2) or D(3)) and genetics affect the response of serum 25(OH)D to vitamin D supplementation. The diversity of opinions that exist on this topic are reflected in the guidelines. Government and scientific societies have published their recommendations for vitamin D intake which vary from 400–1000 IU/d (10–25 μg/d) for an average adult. It was not possible to establish a range of serum 25(OH)D concentrations associated with selected non-musculoskeletal health outcomes. To recommend treatment targets, future studies need to be on infants, children, pregnant and lactating women.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published. ; Background: Unlike in HIV-1 infection, the majority of HIV-2 patients produce broadly reactive neutralizing antibodies, control viral replication and survive as elite controllers. The identification of the molecular, structural and evolutionary footprints underlying these very distinct immunological and clinical outcomes may lead to the development of new strategies for the prevention and treatment of HIV infection. ; Methodology/Principal Findings: We performed a side-by-side molecular, evolutionary and structural comparison of the C2, V3 and C3 envelope regions from HIV-1 and HIV-2. These regions contain major antigenic targets and are important for receptor binding. In HIV-2, these regions also have immune modulatory properties. We found that these regions are significantly more variable in HIV-1 than in HIV-2. Within each virus, C3 is the most entropic region followed by either C2 (HIV-2) or V3 (HIV-1). The C3 region is well exposed in the HIV-2 envelope and is under strong diversifying selection suggesting that, like in HIV-1, it may harbour neutralizing epitopes. Notably, however, extreme diversification of C2 and C3 seems to be deleterious for HIV-2 and prevent its transmission. Computer modelling simulations showed that in HIV-2 the V3 loop is much less exposed than C2 and C3 and has a retractile conformation due to a physical interaction with both C2 and C3. The concealed and conserved nature of V3 in the HIV-2 is consistent with its lack of immunodominancy in vivo and with its role in preventing immune activation. In contrast, HIV-1 had an extended and accessible V3 loop that is consistent with its immunodominant and neutralizing nature. ; Conclusions/Significance: We identify significant structural and functional constrains to the diversification and evolution of C2, V3 and C3 in the HIV-2 envelope but not in HIV-1. These studies highlight fundamental differences in the biology and infection of HIV-1 and HIV-2 and in their mode of interaction with the human immune system and may inform new vaccine and therapeutic interventions against these viruses. ; Fundo para a Ciência e Tecnologia, Portugal. Collaborative HIV and Anti-HIV Drug Resistance Network, European Union. PB and IB supported by PhD grants from Fundo para a Ciência e Tecnologia.

Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- J.publ.g. 593 d

E. Dühring ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- Cam. 31 syg

The Tweed Family Papers consists primarily of correspondence between Mrs. Richard Tweed and her children, relatives, and friends. Diaries, essays and poetry written by family members, newspaper clippings (photocopies), and financial and legal material are also included, as are a handful of photographs. All related primarily to the life of Mrs. Richard Tweed and her descendants. ; Mrs. Richard Tweed, upon whom the majority of the materials focus, was the sister-in-law of William Marcy ("Boss") Tweed, who controlled the Democratic political machine at New York City's Tammany Hall during the mid-19th century. He and his associates misappropriated public funds on a large scale, leading to his arrest and imprisonment in 1871. ; The Tweed Family Papers are organized by the following categories: Correspondence, Newspapers, Literary Production, Photographs, Financial Material, Printed Material, Scrapbook Material, Legal Material, and Artifacts. ; Tweed Family Papers, 1836-1932 and undated, Southwest Collection/Special Collections Library, Texas Tech University, Lubbock, Texas ; Box 1, File 12

Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- 4 Helv. 554 s

übers. von S. Kokosky ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- Pol.g. 195 ph

Includes bibliographical references. ; Bd. 1. Gedichte, Versepen, Dramen, Autobiographisches.--Bd. 2. Romane, Erzählungen.--Bd. 3. Schriften zur Literatur -- Bd. 4. Nachlese der Gedichte Erzählerische und dramatische Fragmente. Tagebücher 1798-1815 -- Bd. 5. Politische und historische Schriften. Streitschriften ; Mode of access: Internet.