Suchergebnisse

This research was funded by Instituto de Salud Carlos III through FIS project PI 15/00110 co-funded by FEDER from Regional Development European Funds (European Union) and the FOIE GRAS project, which has received funding from the European Union's Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant (Agreement No. 722619). ; Peer reviewed

Objective: The aim of this study was to clarify the expression of Ninj1 in endometriosis and adenomyosis lesions, and its inductive factor in human endometriotic stromal cells (ESCs). Background: Nerve injury-induced protein 1 (Ninj1) is a molecule originally identified in dorsal root ganglion neurons and Schwann cells after nerve injury and promotes neurite outgrowth. The aim of this study was to clarify the expression of Ninj1 in endometriosis and adenomyosis lesions, and its inductive factor in human endometriotic stromal cells (ESCs). Materials and Methods: Tissues were obtained with consent from patients diagnosed with ovarian endometrioma (n = 15 in total), peritoneal endometriosis (n = 5), adenomyosis (n = 5), and other gynecological disorders (n = 5, control) during surgery. Immunohistochemistry was conducted in order to detect Ninj1 protein expression in the lesion of endometriosis, adenomyosis, and eutopic endometrium. Nerve fibers in the ovarian endometrioma were detected by positive staining of PGP-9.5. To evaluate the effects of IL-1β on Ninj1 gene expression in endometriosis, ESCs isolated from ovarian endometrioma (n = 5) were treated with IL-1β (5 ng/mL) for 3 or 6 hours. Messenger RNA (mRNA) expression for Ninj1 was examined using quantitative RT-PCR. Results: The Ninj1 protein was expressed by ovarian endometrioma, peritoneal endometriotic, and adenomyotic tissue. Nerve fibers were found in the areas of positive staining for Ninj1 in ovarian endometrioma. IL-1β, an indicator of inflammation in endometriosis, significantly increased Ninj1 mRNA expression by ESC. Conclusion: Our study demonstrates that Ninj1 is expressed in endometriosis and adenomyosis and is induced by the inflammatory stimuli. Given the neurogenetic property of Ninj1, our results imply that Ninj1, induced by inflammation in endometriosis lesion, may contribute to the pathogenesis of pain symptoms characteristic of endometriosis.

Previous models of therapeutic treatment for self-injury have been focused on individualistic psycho-medical approaches that isolate and stigmatize people who cut, burn, and otherwise self-harm. The rise of cyber communities of self-injury, beginning in the early 2000s but evolving dramatically over the first decade of the twenty-first century, has offered a diversity of groups that individuals can join, cycling through different ones as their movement through their career of self-injury evolves. These groups offer a significantly different set of norms and values relating to self-injury, engaging in some combination of defining it, normalizing it, supporting it, and offering a range of techniques for combatting it. In this article we discuss the various ways different people participate in these cyber communities, their relationships between the cyber and face-to-face worlds, and the effects of the Internet on self-injury. We conclude by discussing the instrumental and expressive effects of cyber self-injury support groups, and the way these groups function to normalize the behavior and foster its moral passage.

Presents examples of how state health departments are achieving impressive results preventing injuries and violence among their populations. ; Title from PDF t.p. (viewed Nov. 28, 2006). ; This comendium was made possible through funding frmo CDC's National Center for Injury Prevention and Control cooperative agreement ; Mode of access: Internet. ; Includes bibliographical references.

Over 2 decades ago, the United States National Academy of Sciences described injuries as "the most under-recognized major public health problem facing the nation." Our progress since then has been limited. Injuries still account for nearly 1 out of every 10 deaths in the world, and the global burden of injury is projected to increase over the next decade, predominately in low- and middle-income countries. Despite this, injury prevention receives scant attention from legislators, the education system, and, most strikingly, the health care system. The lifestyle medicine community, however, is beginning to focus on injury prevention and will play an increasing role in helping control the burden of injury. Lifestyle medicine practitioners are in a tremendous position to promote injury prevention. Physical activity and positive lifestyle changes can be accompanied with an increased focus on preventing injury. Lifestyle medicine can prevent injuries by supporting legislation, advancing medical advocacy, providing community education, and linking clinical care with injury prevention.

Radiation damages normal tissues that can adversely affect the success of cancer radiotherapy, safety of nuclear installation workers and military personnel, and public exposed to nuclear accidents. Certain chemicals are able to protect against the harmful effects of radiation. But more than 50 years of research has produced only one approved radioprotective drug, WR-2721 or amifostine. The general utility of WR-2721 is limited by its inherent toxicity and high cost. Efforts to find non-toxic radioprotectors have revealed the promising properties of some medicinal plants. This is an attempt to review the recent publications on radioprotectors and to identify the research needs relevant to developing countries.Defence Science Journal, 2011, 61(2), pp.105-112, DOI:http://dx.doi.org/10.14429/dsj.61.829