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Advances in genetics have begun to deliver on their promise of new and improved approaches to the prevention and treatment of human disease, including the gene-based therapeutics. The international sports community has begun to recognize the potential harmful use of gene transfer technology by athletes. The task of monitoring and controlling sports doping must be a truly cooperative effort, involving the cooperation of a range of local, national, and international organizations. There are very serious broad social and ethical issues at stake that relate to our definition of sports and its role in our society, as well as the social and ethical principles that are challenged or breached through sport doping, determining which forms of performance enhancement - in sport or any other realm of human activity - are acceptable, and what makes the enhancement of sport performance different from enhancement in other areas of human activity (e.g., cosmetic surgery, mood and learning enhancement through drugs, and drug-based treatment of physical and intellectual changes in normal aging process). This book tackles all these issues and more, serving as the first such focused treatment of this increasingly important topic, which has broad-based implications for science, medicine, sports, and society.

Front Cover -- Advances in Genetics -- ADVANCES IN GENETICS, VOLUME 97 -- Advances in GeneticsEdited byTheodore FriedmannDepartment of Pediatrics, University of California at San Diego,School of Me ... -- Advances in GeneticsEdited byTheodore FriedmannDepartment of Pediatrics, University of California at San Diego,School of Me ... -- Contents -- CONTRIBUTORS -- One - Sixteen Years of Meiotic Silencing by Unpaired DNA -- 1. INTRODUCTION -- 2. THE DISCOVERY OF MEIOTIC SILENCING BY UNPAIRED DNA -- 2.1 Asm-1, a Conserved Regulator of Fungal Development -- 2.2 Mating in Neurospora crassa -- 2.3 Ascus Dominance and Gene Pairing During Meiosis -- 2.4 Meiotic Silencing by Unpaired DNA -- 3. GENETIC ANALYSIS OF THE UNPAIRED DNA DETECTION MECHANISM OF MEIOTIC SILENCING BY UNPAIRED DNA -- 3.1 Properties of Unpaired DNA Required for Silencing -- 3.2 Meiotic Silencing by Unpaired DNA Silencing Does Not Spread Between Asci or Genes -- 3.3 DNA Methylation Interferes With the Identification of Pairing Partners -- 3.4 The Search for Pairing Partners Is Spatially Constrained -- 4. RNA SILENCING AND MEIOTIC SILENCING BY UNPAIRED DNA PROTEINS -- 4.1 Silencing the Silencer -- 4.2 Meiotic Silencing by Unpaired DNA Is a Small RNA-Based Silencing Pathway -- 4.3 Identification and Characterization of Other Meiotic Silencing by Unpaired DNA Proteins -- 4.4 A Silencing Complex Stands Guard Around the Nucleus During Meiosis -- 4.5 A Model for Meiotic Silencing by Unpaired DNA -- 5. MEIOTIC SILENCING BY UNPAIRED DNA IN THE WILD -- 6. THE PURPOSE OF MEIOTIC SILENCING BY UNPAIRED DNA -- 7. CONCLUSION -- REFERENCES -- Two - Sleeping Beauty? Developmental Timing, Sleep, and the Circadian Clock in Caenorhabditis elegans -- 1. INTRODUCTION -- 2. CIRCADIAN CLOCKS AND THE CAENORHABDITIS ELEGANS DEVELOPMENTAL TIMER -- 2.1 Postembryonic Development in Caenorhabditis elegans