The Use of High-Resolution Metabolomics in Occupational Exposure and Health Research
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 61, Heft 4, S. 395-397
ISSN: 2398-7316
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In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 61, Heft 4, S. 395-397
ISSN: 2398-7316
In: The annals of occupational hygiene: an international journal published for the British Occupational Hygiene Society, Band 60, Heft 8, S. 913-915
ISSN: 1475-3162
In: The annals of occupational hygiene: an international journal published for the British Occupational Hygiene Society, Band 60, Heft 9, S. 1039-1048
ISSN: 1475-3162
In: The annals of occupational hygiene: an international journal published for the British Occupational Hygiene Society, Band 60, Heft 6, S. 669-683
ISSN: 1475-3162
In: The annals of occupational hygiene: an international journal published for the British Occupational Hygiene Society, Band 60, Heft 5, S. 551-566
ISSN: 1475-3162
In: The annals of occupational hygiene: an international journal published for the British Occupational Hygiene Society, Band 59, Heft 6, S. 681-704
ISSN: 1475-3162
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 67, Heft 9, S. 1056-1068
ISSN: 2398-7316
Abstract
Night-shift workers often sleep at moments, not in sync with their circadian rhythm. Though the acute effects of night-shift work on sleep quality directly after a night shift are well described, less is known about the chronic effects of night-shift work on sleep. We associated ever-working night shifts and recently working night shifts (<4 wk) with lifetime use of sleep medication and melatonin, self-reported average sleep duration and sleep quality over the 4 wk preceding inclusion (measured using the Medical Outcomes Study Sleep scale). We explored trends in sleep outcomes with average frequency of night shifts per week, tenure of night-shift works in years, and time since last performed night work. This research was conducted within the Nightingale study which is a Dutch cohort study of 59,947 female registered nurses aged 18 to 65. Working night shifts was not associated with self-reported nonoptimal sleep length and sleep quality. However, we observed higher odds of lifetime use of sleep medication for nurses who ever-worked night shifts (OR 1.24; 95% CI 1.13, 1.35) and who recently worked night shifts (OR 1.13; 95% CI 1.05, 1.22); with night-shift work frequency and tenure being associated with lifetime use of sleep medication (P-value for trend < 0.001 for both). Odds for melatonin use were elevated for nurses who ever worked night shifts (OR 1.55; 95% CI 1.40, 1.71) and recently worked night shifts (OR 1.72; 95% CI 1.59, 1,86). The findings of this study have practical implications for healthcare organizations that employ nurses working night shifts. The observed associations between night-shift work and increased lifetime use of prescribed sleep medication and melatonin highlight the need for targeted support and interventions to address the potential long-term sleep problems faced by these nurses.
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 64, Heft 5, S. 465-467
ISSN: 2398-7316
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 64, Heft 8, S. 909-909
ISSN: 2398-7316
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 63, Heft 2, S. 148-157
ISSN: 2398-7316
In: ENVSOFT-D-24-00969
SSRN
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 66, Heft 5, S. 671-686
ISSN: 2398-7316
Abstract
Objectives
The Network on the Coordination and Harmonisation of European Occupational Cohorts (OMEGA-NET) was set up to enable optimization of the use of industrial and general population cohorts across Europe to advance aetiological research. High-quality harmonized exposure assessment is crucial to derive comparable results and to enable pooled analyses. To facilitate a harmonized research strategy, a concerted effort is needed to catalogue available occupational exposure information. We here aim to provide a first comprehensive overview of exposure assessment tools that could be used for occupational epidemiological studies.
Methods
An online inventory was set up to collect meta-data on exposure assessment tools. Occupational health researchers were invited via newsletters, editorials, and individual e-mails to provide details of job-exposure matrices (JEMs), exposure databases, and occupational coding systems and their associated crosswalks to translate codes between different systems, with a focus on Europe.
Results
Meta-data on 36 general population JEMs, 11 exposure databases, and 29 occupational coding systems from more than 10 countries have been collected up to August 2021. A wide variety of exposures were covered in the JEMs on which data were entered, with dusts and fibres (in 14 JEMs) being the most common types. Fewer JEMs covered organization of work (5) and biological factors (4). Dusts and fibres were also the most common exposures included in the databases (7 out of 11), followed by solvents and pesticides (both in 6 databases).
Conclusions
This inventory forms the basis for a searchable web-based database of meta-data on existing occupational exposure information, to support researchers in finding the available tools for assessing occupational exposures in their cohorts, and future efforts for harmonization of exposure assessment. This inventory remains open for further additions, to enlarge its coverage and include newly developed tools.
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 62, Heft 9, S. 1047-1063
ISSN: 2398-7316
In: Scandinavian journal of work, environment & health, Band 50, Heft 5, S. 351-358
ISSN: 1795-990X
OBJECTIVES: Previous studies established a causal relationship between occupational benzene exposure and acute myeloid leukemia (AML). However, mixed results have been reported for associations between benzene exposure and other myeloid and lymphoid malignancies. Our work examined whether occupational benzene exposure is associated with increased mortality from overall lymphohaematopoietic (LH) cancer and major subtypes.
METHODS: Mortality records were linked to a Swiss census-based cohort from two national censuses in 1990 and 2000. Cases were defined as having any LH cancers registered in death certificates. We assessed occupational exposure by applying a quantitative benzene job-exposure matrix (BEN-JEM) to census-reported occupations. Exposure was calculated as the products of exposure proportions and levels (P × L). Cox proportional hazards models were used to calculate LH cancer death hazard ratios (HR) and 95% confidence intervals (CI) associated with benzene exposure, continuously and in ordinal categories.
RESULTS: Our study included approximately 2.97 million persons and 13 415 LH cancer cases, including 3055 cases with benzene exposure. We observed increased mortality risks per unit (P × L) increase in continuous benzene exposure for AML (HR 1.03, 95% CI 1.00–1.06) and diffuse large B-cell lymphoma (HR 1.09, 95% CI 1.04–1.14). When exposure was assessed categorically, increasing trends in risks were observed with increasing benzene exposure for AML (P=0.04), diffuse large B-cell lymphoma (P=0.02), and follicular lymphoma (P=0.05).
CONCLUSION: In a national cohort from Switzerland, we found that occupational exposure to benzene is associated with elevated mortality risks for AML, diffuse large B-cell lymphoma, and possibly follicular lymphoma.
In: Annals of work exposures and health: addressing the cause and control of work-related illness and injury, Band 61, Heft 7, S. 759-772
ISSN: 2398-7316