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Manetti's Latin treatise Adversus Iudaeos et Gentes (Against the Jews and Gentiles) offers a polemical defense of the Christian religion. This volume, which includes the first four books,surveys human history from the Creation to the life,teaching, and resurrection of Christ. Book I begins with the creation and fall of man in the Biblical account. There follows a long digression adversus gentes (the Gentiles, i.e., pagans), which reviews central points of ancient Greek and Roman philosophy and religion, and censures the ancients for their senseless doctrines and bloody rites. Manetti then returns to the Jews, whose beliefs and practices are praised from Abraham to Moses. During their centuries of "true" piety, Manetti calls the chosen people "Hebrews." But from the time of the Exodus onwards, he censures them as "Jews" because they observe the absurd and cruel practices of Pentateuchal legislation, which he views as analogous to pagan rites. Manetti stresses several themes in Jewish history: the early development of the concept of righteousness, the Exodus, the Mosaic Law and its inadequacy--thus providing a "preparation for the Gospel" in Eusebius' sense. The next three books provide a synoptic biography of Jesus in three stages. Book II describes the life of Christ up to the raising of Lazarus; Book III relates his teaching, and Book IV offers an account of Christ's passion, death, and resurrection.--

The volume contains 320 letters and enclosures from around 30 correspondences. Four major developments dominate his conversations during these three years and lead to new themes: the astronomical, political, and theological aspects of the 1700 Protestant calendar reform; the newly founded Sozietät der Wissenschaften in Berlin; the discussion on Leibniz's differential calculus, and the controversy with Denis Papin concerning dynamics.