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1 Alcohol Use and Abuse: Historical Perspective and Present Trends -- 1. Alcohol Use in Historical Perspective -- 2. Alcohol Consumption and Alcohol Problems -- 3. Development of the Concept(s) of Alcoholism -- 4. References -- 2 The Genetics of Alcoholism -- 1. Types of Studies Supporting a Genetic Influence in Alcoholism -- 2. Possible Biological Mechanisms for a Genetic Influence in Alcoholism -- 3. A Prospective Search for the Biological Determinants of Alcoholism -- 4. Summary -- 5. References -- 3 The Absorption, Distribution, and Metabolism of Ethanol and Its Effects on Nutrition and Hepatic Function -- 1. Introduction -- 2. Absorption and Distribution -- 3. Pharmacokinetics and Alcohol Elimination Rates -- 4. Processes and Organs Responsible for Ethanol Elimination -- 5. Significant Pathways of Ethanol Metabolism -- 6. Enzymes That Oxidize Ethanol to Acetaldehyde -- 7. Enzymes That Oxidize Acetaldehyde to Acetate -- 8. Control of Ethanol and Acetaldehyde Metabolism in Liver -- 9. Effect of Chronic Ethanol Ingestion on Alcohol Elimination Rate -- 10. Chronic Ethanol Ingestion and Nutrition -- 11. Ethanol Oxidation and Hepatic Metabolism -- 12. References -- 4 Effects of Ethanol upon Organ Systems Other than the Central Nervous System -- 1. Introduction -- 2. Ethanol and the Gastrointestinal Tract -- 3. Muscle Systems -- 4. The Hematologic System -- 5. Kidney Disease and Alcoholism -- 6. Pulmonary Disease and Alcoholism -- 7. The Endocrine System and Alcoholism -- 8. Effects of Ethanol on the Hypothalamic-Pituitary-Adrenal Axis -- 9. Effects of Alcohol on the Hypothalamic-Pituitary-Thyroidal Axis -- 10. The Effects of Alcohol on Growth Hormone and Prolactin -- 11. Effects of Alcohol on Vasopressin and Oxytocin -- 12. Biological Markers of Alcoholism -- 13. References -- 5 Ethanol and the Central Nervous System -- 1. Ethanol and Behavior -- 2. Ethanol and Membrane Structure and Function -- 3. Ethanol and Electrical Cellular Activity -- 4. Ethanol and Synaptic Transmission -- 5. Ethanol and Metabolism -- 6. Consequences of Long-term Ethanol Consumption -- 7. Summary -- 8. References -- 6 Neurologic Diseases Associated with Chronic Alcohol Abuse -- 1. Introduction -- 2. Physical Dependence -- 3. Chronic Diseases of the Central Nervous System -- 4. Peripheral Polyneuropathy -- 5. Nutritional Deficiencies -- 6. Conclusions -- 7. References -- 7 Biology of Tolerance and Dependence -- 1. Introduction to Tolerance and Dependence -- 2. Factors Contributing to Tolerance and Dependence -- 3. Classifications and Definitions of Tolerance -- 4. Biochemical Determinants of Ethanol Tolerance -- 5. Characteristics of Physical Dependence on Ethanol -- 6. Etiological Factors Contributing to the Development of Physical Dependence -- 7. Neurochemical Systems Determining Physical Dependence -- 8. Pharmacologic Management of the Acute Alcohol Withdrawal Syndrome -- 9. References -- 8 Alcohol Consumption and Prenatal Development -- 1. Fetal Alcohol Syndrome/Fetal Alcohol Effects -- 2. Alcohol as a Teratogen in Animals, 1973–1979 -- 3. Critical Discussion and General Conclusions -- 4. References -- 9 Interaction of Ethanol with Other Drugs -- 1. Introduction -- 2. Centrally Acting Compounds -- 3. References -- 10 Psychological Correlates and Explantions of Alcohol Use and Abuse -- 1. Psychodynamic Models -- 2. The Disease Model -- 3. Behavioral and Social-Learning Approach -- 4. Future Directions -- 5. References -- 11 Alcoholism Treatment Approaches: Patient Variables, Treatment Variables -- 1. Critical View of Treatment Outcome Evaluation -- 2. Treatment Variables -- 3. Patient Variables -- 4. Implications -- 5. References -- 12 Prevention of Alcohol Abuse -- 1. Approaches to Prevention -- 2. Alcohol Education -- 3. Mass Media -- 4. Alcohol Control Legislation -- 5. Conclusions -- 6. References.