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Through a methodology of documentary and dialectical basis, in the article, the authors investigate the methodological foundations of the spatial development of the region, through the study of its content and conceptual instrument. In the same way, different points of view on the concept of "region" are presented, the fundamental methodological elements of the formation and organization of the socio-economic development of the region are listed, characterizing the potential of natural resources and the socio-economic development of the municipal districts. Based on this information, the region's place in the social division of labor was determined, the development prospects of the districts were outlined, and the cause-and-effect relationships of the region's socioeconomic indicators were also established. By way of conclusion, everything indicates that the socio-economic development of the region under modern conditions is seen, in the first place, in self-sufficiency. Therefore, your accumulated potential must first be assessed to make a real assessment and then organize a search for the missing resources and funds. The use of a type of strategic management at all levels of management of the political system is the key to a balanced and successful development.