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Solid pre-clinical investigations serve as the basis for clinical research. High quality clinical trials remain to be definitive measure to evaluate an interventional therapy. Clinical decisions should be independent from media and political propaganda.

Purpose
The consumers want to purchase the target products in the right place, whereas the manufacturers want to allocate their possible products to optimal distribution channels. The manufacturer must know how to handle itself in this business. The study aims to examine the B2B channel decision-making with different product qualities in a non-cooperative supply chain.


Design/methodology/approach
The authors develop a B2B Manufacturer-Stackelberg game as an analytical framework, combining asymmetric preference of purchase channels choice by the consumers, a continuous quality setting of the manufacturer and differential channel structure to study the manufacturer's product strategy and channel optimisation. By horizontal comparisons across four channel structures, product variety can be classified into the differential quality-level zone through exogenous quality intervention, and the preference of manufacturers in each quality-level zone within the structures can be ranked.


Findings
Theoretically and practically, the hybrid-channel structure should be completely neglected when the direct channel dominates the retail channel. In contrast, dual-channel structures dominate single channels irrespective of the channel power, and channel preferences between high-quality and low-quality zones are stable, whereas the preference in medium-quality zone is unstable. In addition, the supply chain system cannot achieve global Pareto improvement without any additional coordination mechanism between the manufacturer and the retailer.


Originality/value
The extended results by numerical examples suggest that the bigger the area of the medium-quality zone, the more significant the product variety of the manufacturer.

To assess the effectiveness of urban energy conservation and GHG mitigation measures, a detailed Long- range Energy Alternatives Planning (LEAP) model is developed and applied to analyze the future trends of energy demand and GHG emissions in Xiamen city. Two scenarios have been designed to describe the future energy strategies in relation to the development of Xiamen city. The 'Business as Usual' scenario assumes that the government will do nothing to influence the long-term trends of urban energy demand. An 'Integrated' scenario, on the other hand, is generated to assess the cumulative impact of a series of available reduction measures: clean energy substitution, industrial energy conservation, combined heat and power generation, energy conservation in building, motor vehicle control, and new and renewable energy development and utilization. The reduction potentials in energy consumption and GHG emissions are estimated for a time span of 2007-2020 under these different scenarios. The calculation results in Xiamen show that the clean energy substitution measure is the most effective in terms of energy saving and GHG emissions mitigation, while the industrial sector has the largest abatement potential.

To assess the effectiveness of urban energy conservation and GHG mitigation measures, a detailed Long- range Energy Alternatives Planning (LEAP) model is developed and applied to analyze the future trends of energy demand and GHG emissions in Xiamen city. Two scenarios have been designed to describe the future energy strategies in relation to the development of Xiamen city. The 'Business as Usual' scenario assumes that the government will do nothing to influence the long-term trends of urban energy demand. An 'Integrated' scenario, on the other hand, is generated to assess the cumulative impact of a series of available reduction measures: clean energy substitution, industrial energy conservation, combined heat and power generation, energy conservation in building, motor vehicle control, and new and renewable energy development and utilization. The reduction potentials in energy consumption and GHG emissions are estimated for a time span of 2007-2020 under these different scenarios. The calculation results in Xiamen show that the clean energy substitution measure is the most effective in terms of energy saving and GHG emissions mitigation, while the industrial sector has the largest abatement potential.