Article(electronic)#1October 9, 2002
Status febrilis, abszedierendes Lungen- infiltrat und Thoraxwandschwellung
In: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum
ISSN: 1424-4020
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Article(electronic)#2September 1, 2010
Okkulte Hepatitis B durch Escape-Mutante?
In: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, Volume 10, Issue 35
ISSN: 1424-4020
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Article(electronic)#3October 5, 2005
Salmonellosen: ein Überblick
In: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, Volume 5, Issue 40
ISSN: 1424-4020
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Article(electronic)#4September 14, 2011
Elizabethkingia meningoseptica auf der IPS: ungewöhnlicher Keim mit Potenzial
In: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, Volume 11, Issue 37
ISSN: 1424-4020
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Article(electronic)#5September 7, 2015
Reduction of Microbial Colonization with a Chlorhexidine-Coated Dressing for External Ventricular Drain (EVD)—A Prospective, Randomized, Controlled, Clinical Trial (EVDAI Study)
In: Journal of neurological surgery. Part A, Central European neurosurgery = Zentralblatt für Neurochirurgie, Volume 76, Issue S 01
ISSN: 2193-6323
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Open Access#62017
Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study
The Swiss National Science Foundation (SNSF) promotes academic excellence through competitive selection of study proposals and rigorous evaluation of feasibility, but completion status and publication history of SNSF-supported randomised clinical trials (RCTs) remain unclear. The main objectives were to review all healthcare RCTs supported by the SNSF for trial discontinuation and non-publication, to investigate potential risk factors for trial discontinuation due to poor recruitment and non-publication, and to compare findings to other Swiss RCTs not supported by the SNSF. We established a retrospective cohort of all SNSF-supported RCTs for which recruitment and funding had ended in 2015 or earlier. For each RCT, two investigators independently searched corresponding publications in electronic databases. In addition, we approached all principal investigators to ask for additional publications and information about trial discontinuation. Teams of two investigators independently extracted details about study design, recruitment of participants, outcomes, analysis and sample size from the original proposal and, if available, from trial registries and publications. We used multivariable regression analysis to explore potential risk factors associated with discontinuation due to poor recruitment and with non-publication, and to compare our results with data from a previous cohort of Swiss RCTs not supported by the SNSF. We included 101 RCTs supported by the SNSF between 1986 and 2015. Eighty-seven (86%) principal investigators responded to our survey. Overall, 69 (68%) RCTs were completed, 26 (26%) RCTs were prematurely discontinued (all due to slow recruitment) and the completion status remained unclear for 6 (6%) RCTs. For analysing publication status, we excluded 4 RCTs for which follow-up was still ongoing and 9 for which manuscripts were still in preparation. Of the remaining 88 RCTs, 53 (60%) were published as full articles in peer-reviewed journals. Multivariable regression models suggested that discontinued ...
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